Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Examination Of The Current Top Candidate Genes For Ad In A Genome-Wide Association Study, T Feulner, Simon Laws, Patricia Friedrich, S Wagenpfeil, S Wurst, K Kuhn, M Krawczak, S Schreiber, S Nikolaus, Hans Foerstl, Alexander Kurz, Matthias Riemenschneider
Examination Of The Current Top Candidate Genes For Ad In A Genome-Wide Association Study, T Feulner, Simon Laws, Patricia Friedrich, S Wagenpfeil, S Wurst, K Kuhn, M Krawczak, S Schreiber, S Nikolaus, Hans Foerstl, Alexander Kurz, Matthias Riemenschneider
Simon Laws
With the advent of technologies that allow simultaneous genotyping of thousands of singlenucleotide polymorphisms (SNPs) across the genome, the genetic contributions to complex diseases can be explored at an unprecedented detail. This study is among the first to apply the genome-wide association study (GWAS) approach to Alzheimer disease (AD). We present our GWAS results from the German population for genes included in the ‘Top Results’ list on the AlzGene database website. In addition to the apolipoprotein E locus, we identified nominally significant association signals in six of the ten genes investigated, albeit predominantly for SNPs other than those already published …