Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Aging (2)
- Actin (1)
- Aorta (1)
- Biomolecular Motors (1)
- Cardiovascular (1)
-
- Contractile proteins (1)
- Eukaryotic elongation factor 2 (1)
- Eukaryotic initiation factor 4E-binding protein 1 (1)
- Fischer 344 / NNIaHSD × Brown Norway / BiNia rat (F344BN or FBN) (1)
- In Vitro Motility (1)
- Mechanotransduction (1)
- Molecular signaling (1)
- Morphological alteration (1)
- Musculoskeletal (1)
- Myogenin (1)
- Myosin II (1)
- Neuronal (1)
- Photoreactive Patterning (1)
- Protein translational signaling (1)
- Respiratory system (1)
- Ribosomal protein S6 (1)
- Skeletal muscle atrophy (1)
- Skin (1)
- UV/Ozone (1)
- Unloading (1)
Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Impaired Overload-Induced Hypertrophy Is Associated With Diminished Mtor Signaling In Insulin-Resistant Skeletal Muscle Of The Obese Zucker Rat, Anjaiah Katta, Sudarsanam Kundla, Sunil Kakarla, Miaozong Wu, Jacqueline Fannin, Satyanarayana Paturi, Hua Liu, Hari Addagarla, Eric Blough
Impaired Overload-Induced Hypertrophy Is Associated With Diminished Mtor Signaling In Insulin-Resistant Skeletal Muscle Of The Obese Zucker Rat, Anjaiah Katta, Sudarsanam Kundla, Sunil Kakarla, Miaozong Wu, Jacqueline Fannin, Satyanarayana Paturi, Hua Liu, Hari Addagarla, Eric Blough
Eric Blough
Recent data have suggested that insulin resistance may be associated with a diminished ability of skeletal muscle to undergo hypertrophy (Paturi S, Gutta AK, Kakarla SK, Katta A, Arnold EC, Wu M, Rice KM, Blough ER. J Appl Physiol 108: 7–13, 2010). Here we examine the effects of insulin resistance using the obese Zucker (OZ) rat with increased muscle loading on the regulation of the mammalian target of rapamycin (mTOR) and its downstream signaling intermediates 70-kDa ribosomal protein S6 kinase (p70S6k), ribosomal protein S6 (rpS6), eukaryotic elongation factor 2 (eEF2), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1). Compared with …
Effect Of Aging On Cellular Mechanotransduction, Miaozong Wu, Jacqueline Fannin, Kevin Rice, Bin Wang, Eric Blough
Effect Of Aging On Cellular Mechanotransduction, Miaozong Wu, Jacqueline Fannin, Kevin Rice, Bin Wang, Eric Blough
Eric Blough
Aging is becoming a critical heath care issue and a burgeoning economic burden on society. Mechanotransduction is the ability of the cell to sense, process, and respond to mechanical stimuli and is an important regulator of physiologic function that has been found to play a role in regulating gene expression, protein synthesis, cell differentiation, tissue growth, and most recently, the pathophysiology of disease. Here we will review some of the recent findings of this field and attempt, where possible, to present changes in mechanotransduction that are associated with the aging process in several selected physiological systems, including musculoskeletal, cardiovascular, neuronal, …
Regulation Of Contractile Proteins And Protein Translational Signaling In Disused Muscle, Hua Liu, Eric Blough, Ravi Arvapalli, Yeling Wang, Peter Reiser, Satyanarayana Paturi, Anjaiah Katta, Robert Harris, Niraj Nepal, Miaozong Wu
Regulation Of Contractile Proteins And Protein Translational Signaling In Disused Muscle, Hua Liu, Eric Blough, Ravi Arvapalli, Yeling Wang, Peter Reiser, Satyanarayana Paturi, Anjaiah Katta, Robert Harris, Niraj Nepal, Miaozong Wu
Eric Blough
Background/Aims: Muscle disuse can lead to muscle atrophy and impaired skeletal muscle function. How skeletal muscle modulates protein translational signaling in response to prolonged muscle disuse is not well understood. Using the hindlimb unloading (HU) model of muscle atrophy we examined how hindlimb unweighting affects protein translational signaling, including the activation of Akt/mTOR/p70S6K/S6 signaling and the inhibitory association of 4EBP1 with translation initiation factor eIF4E. Methods: Male F344BN rats were randomized into baseline control, or subjected to HU for 3, 7 or 14 days. Body weight, gastrocnemius muscle, and individual myofiber cross-sectional area were measured to evaluate the degree of …
Assembly And Function Of Myosin Ii On Ultraviolet/Ozone Patterned Trimethylchlorosilane Substrates, Hideyo Takatsuki, Madhukar Kolli, Kevin Rice, B. Day, Shinichi Asano, Mashiur Rahman, Yue Zhang, Ryoki Ishikawa, Kazuhiro Kohama, Eric Blough
Assembly And Function Of Myosin Ii On Ultraviolet/Ozone Patterned Trimethylchlorosilane Substrates, Hideyo Takatsuki, Madhukar Kolli, Kevin Rice, B. Day, Shinichi Asano, Mashiur Rahman, Yue Zhang, Ryoki Ishikawa, Kazuhiro Kohama, Eric Blough
Eric Blough
The study of biomolecular motors represents a rapidly and progressing field of nanobiotechnology. Here, we present a simple method for patterning myosin II on a microstructured surface. Our findings indicate that UV/ozone treatment can be used to alter the hydrophobicity of trimethyl-chloro-silane (TMCS) coated glass surfaces, to alter protein binding, and effectively produce localized motor activity. Taken together, these data suggest that photoreactive patterning may be useful for the selective localization of functional myosin II motor tracks.
Deferasirox Removes Cardiac Iron And Attenuates Oxidative Stress In The Iron-Overloaded Gerbil, Rabaa Al-Rousan, Satyanarayana Paturi, Joseph Laurino, Sunil Kakarla, Anil Gutta, Ernest Walker, Eric Blough
Deferasirox Removes Cardiac Iron And Attenuates Oxidative Stress In The Iron-Overloaded Gerbil, Rabaa Al-Rousan, Satyanarayana Paturi, Joseph Laurino, Sunil Kakarla, Anil Gutta, Ernest Walker, Eric Blough
Eric Blough
Iron-induced cardiovascular disease is the leading cause of death in iron-overloaded patients. Deferasirox is a novel, once daily oral iron chelator that was recently approved for the treatment of transfusional iron overload. Here, we investigate whether deferasirox is capable of removing cardiac iron and improving iron-induced pathogenesis of the heart using the iron overload gerbil model. Animals were randomly divided into three groups: control, iron overload, and iron overload + deferasirox treatment. Iron-dextran was given 100 mg/kg per 5 days i.p for 10 weeks. Deferasirox treatment was taken post iron loading and was given at 100 mg/kg/day p.o for 1 …
Iron-Induced Cardiac Damage: Role Of Apoptosis And Deferasirox Intervention, Yeling Wang, Miaozong Wu, Rabaa Al-Rousan, Hua Liu, Jacqueline Fannin, Satyanarayana Paturi, Ravi Arvapalli, Anjaiah Katta, Sunil Kakarla, Kevin Rice, William Triest, Eric Blough
Iron-Induced Cardiac Damage: Role Of Apoptosis And Deferasirox Intervention, Yeling Wang, Miaozong Wu, Rabaa Al-Rousan, Hua Liu, Jacqueline Fannin, Satyanarayana Paturi, Ravi Arvapalli, Anjaiah Katta, Sunil Kakarla, Kevin Rice, William Triest, Eric Blough
Eric Blough
Excess cardiac iron levels are associated with cardiac damage and can result in increased morbidity and mortality. Here, we hypothesize that elevations in tissue iron can activate caspase-dependent signaling, which leads to increased cardiac apoptosis and fibrosis, and that these alterations can be attenuated by iron chelation. Using an iron-overloaded gerbil model, we show that increased cardiac iron is associated with reduced activation of Akt (Ser473 and Thr308), diminished phosphorylation of the proapoptotic regulator Bad (Ser136), and an increased Bax/Bcl-2 ratio. These iron-overload-induced alterations in Akt/Bad phosphorylation and Bax/Bcl-2 ratio were coupled with increased activation of the downstream caspase-9 (40/38- …
Aortic Aging In The Fischer 344 / Nniahsd × Brown Norway / Binia Rat, Kevin Rice, Miaozong Wu, Eric Blough
Aortic Aging In The Fischer 344 / Nniahsd × Brown Norway / Binia Rat, Kevin Rice, Miaozong Wu, Eric Blough
Eric Blough
Aging is now recognized as one of major risk factors for cardiovascular disease (CVD). It is well documented that elderly populations show increased incidence of CVD symptomology but whether these changes are directly related to aging is not well understood since the possibility exists that other age-associated pathologies in different organ systems could impact on cardiovascular function. Hence, the development of an aging model with reduced systemic illness could invigorate efforts to understand the direct role of aging in CVD progression. The Fischer 344 / NNIaHSD × Brown Norway / BiNia rat (F344BN) has been proposed as a potential model …