Medicine and Health Sciences Commons^™

Psychiatric Outcomes In A Resident-Run Multidisciplinary Hepatitis C Clinic, Nicole M. Agostino Do, Edward Norris Md, Fapm, Joseph L. Yozviak Do, Facp, Charles M. Brooks Md, Eric J. Gertner Md, Mph, Michael Kaufmann Md

Edward R Norris MD, FAPA, FAPM

No abstract provided.

Training Tomorrow’S Providers And Expanding Access To Peginterferon/Ribavirin Combination Therapyfor Chronic Hepatatis C In Underinsured/Uninsured Patients: Final Outcomes Of A Pilot, Resident-Initiated, Multidisciplinary, Hepatitis C Clinic, Nicole M. Agostino Do, Suzanne J. Templer Do, Edward Norris Md, Fapm, Charles M. Brooks Md, Eric J. Gertner Md, Mph, Joseph L. Yozviak Do, Facp

Edward R Norris MD, FAPA, FAPM

No abstract provided.

Anomalous Right Coronary Artery Arising From The Pulmonary Artery, Ashish Kabra, James Wu, Matthew Martinez

James K Wu MD

No abstract provided.

Fabry's Disease With Lvot Obstruction: Diagnosis And Management, Jacob Blount, James Wu, Matthew Martinez

James K Wu MD

A 46-year-old male was diagnosed with hypertrophic cardiomyopathy (HCM) and severe left ventricular outflow tract (LVOT) obstruction. Genetic testing revealed that this was a "mimic of HCM" and the true diagnosis was Fabry's disease, although there were no other clinical features of Fabry's. Despite maximal medical therapy he remained symptomatic from the outflow tract gradient and required surgical myectomy for symptom relief. This case illustrates the diagnosis of an HCM mimic by genetic testing.

Durability, Reliability, Viability: 48 Year-Survival Of A Starr-Edwards Mitral Valve, Bilal Ayub, Justin Guthier, James Wu

James K Wu MD

No abstract provided.

Venous Thromboembolism In Patients With Heart Failure: In-Hospital And Chronic Use Of Anti-Coagulants For Prevention, Nasir Shariff, Abdul Aleem, Vadim Levin, Sudip Nanda, Matthew Martinez, Stacey Smith, Ronald Freudenberger

Vadim A Levin MD

No abstract provided.

Ranolazine—Treatment Of Ventricular Tachycardia And Symptomatic Ventricular Premature Beats In Ischemic Cardiomyopathy, Sudip Nanda, Vadim Levin, Matthew Martinez, Ronald Freudenberger

Vadim A Levin MD

No abstract provided.

Atrial Fibrillation In Patients With Heart Failure: Role Of Catheter Ablation Therapies, Nasir Shariff, Abdul Aleem, Vadim Levin, Mukesh Singh, Nauman Islam, Ronald Freudenberger

Vadim A Levin MD

No abstract provided.

Interatrial Conduction Correlates With Optimal Atrioventricular Timing In Cardiac Resynchronization Therapy Devices, Vadim Levin, Mehdi Razavi, Robert Coll, James Coles, Aleksandre Sambelashvili

Vadim A Levin MD

No abstract provided.

Dabigatran: A New Chapter In Anticoagulation, Shawn Ahmed, Vadim Levin, Robert Malacoff, Matthew Martinez

Vadim A Levin MD

No abstract provided.

Novel Oral Anticoagulants For Stroke Prevention In Patients With Atrial Fibrillation: Dawn Of A New Era, Tahmeed Contractor, Vadim Levin, Matthew Martinez, Francis Marchinski

Vadim A Levin MD

No abstract provided.

Prolactin And Fmri Response To Skf38393 In The Baboon, Brad D. Miller, Lauren A. Marks, Jonathan M. Koller, Blake J. Newman, G Larry Bretthorst, Kevin J. Black

Kevin J. Black, MD

Background: This study’s goal was to provide dose-response data for a dopamine agonist in the baboon using standard methods (replicate measurements at each dose, across a range of doses), as a standard against which to subsequently validate a novel pharmacological MRI (phMRI) method. Dependent variables were functional MRI (fMRI) data from brain regions selected a priori, and systemic prolactin release. Necessary first steps included estimating the magnitude and time course of prolactin response to anesthesia alone and to various doses of agonist. These first steps (“time course studies”) were performed with three agonists, and the results were used to select …

Plasma Apolipoprotein E And Alzheimer Disease Risk: The Aibl Study Of Aging, Veer Bala Gupta, Simon Laws, Victor Villemagne, David Ames, Ashley Bush, Kathryn Ellis, James Lui, Colin Masters, Christopher Rowe, Cassandra Szoeke, Kevin Taddei, Ralph Martins

Simon Laws

Objective: There is mounting evidence for the contribution of apoE to the pathophysiology of Alzheimer disease (AD). Studies also indicate that plasma apoE levels may reflect disease status, suggesting that apoE is a potential AD biomarker. However, while some studies of apoE levels in plasma have presented correlations with AD pathology, others have not. Thus, there is a lack of consensus as to the suitability of plasma apoE as an AD biomarker. The major objective of this cross-sectional study was to investigate total plasma apoE as well as levels of the apoE4 form in a large, highly characterized cohort which …

Gonadotropins And Cognition In Older Women, Mark Rodrigues, Giuseppe Verdile, Jonathan Foster, Eva Hogervorst, Karen Joesbury, Satvinder Dhaliwal, Elizabeth Corder, Simon Laws, Eugene Hone, Richard Prince, Amanda Devine, Pankaj Mehta, John Beilby, Craig Atwood, Ralph Martins

Simon Laws

Recent research studies associate elevated gonadotropin levels with dementia. Specifically, an age associated increase in levels of luteinizing hormone has been linked to an increased risk of Alzheimer's disease. The objective of this study was to investigate the association between gonadotropin levels and cognition in older, healthy postmenopausal women. Cognitive functioning was compared with plasma levels of estradiol, luteinizing hormone, follicle stimulating hormone, Aβ40 and APOE genetic status in 649 community-dwelling, non-demented older women residing in Western Australia. High endogenous luteinizing hormone levels were associated with a lower cognitive score, especially in older women and in those women that were …

Shoulder Pain In Primary Care: Diagnostic Accuracy Of Clinical Examination Tests For Non-Traumatic Acromioclavicular Joint Pain, Angela Cadogan, Peter Mcnair, Mark Laslett, Wayne Hing

Wayne Hing

Background: Despite numerous methodological flaws in previous study designs and the lack of validation in primary care populations, clinical tests for identifying acromioclavicular joint (ACJ) pain are widely utilised without concern for such issues. The aim of this study was to estimate the diagnostic accuracy of traditional ACJ tests and to compare their accuracy with other clinical examination features for identifying a predominant ACJ pain source in a primary care cohort. Methods: Consecutive patients with shoulder pain were recruited prospectively from primary health care clinics. Following a standardised clinical examination and diagnostic injection into the subacromial bursa, all participants received …

Human Monoclonal Antibodies Directed Against Toxins A And B Prevent Clostridium Difficile-Induced Mortality In Hamsters, Gregory Babcock, Teresa Broering, Hector Hernandez, Robert Mandell, Katherine Donahue, Naomi Boatright, Anne Stack, Israel Lowy, Robert Graziano, Deborah Molrine, Donna Ambrosino, William Thomas

William D Thomas Jr

Clostridium difficile is the leading cause of nosocomial antibiotic-associated diarrhea, and recent outbreaks of strains with increased virulence underscore the importance of identifying novel approaches to treat and prevent relapse of Clostridium difficile-associated diarrhea (CDAD). CDAD pathology is induced by two exotoxins, toxin A and toxin B, which have been shown to be cytotoxic and, in the case of toxin A, enterotoxic. In this report we describe fully human monoclonal antibodies (HuMAbs) that neutralize these toxins and prevent disease in hamsters. Transgenic mice carrying human immunoglobulin genes were used to isolate HuMAbs that neutralize the cytotoxic effects of either toxin …

Lineage-Specific T-Cell Responses To Cancer Mucosa Antigen Oppose Systemic Metastases Without Mucosal Inflammatory Disease., Adam Snook, Peng Li, Benjamin J Stafford, Elizabeth J Faul, Lan Huang, Ruth C Birbe, Alessandro Bombonati, Stephanie Schulz, Matthias Schnell, Laurence Eisenlohr, Scott Waldman

Adam E Snook

Cancer mucosa antigens are emerging as a new category of self-antigens expressed normally in immunologically privileged mucosal compartments and universally by their derivative tumors. These antigens leverage the established immunologic partitioning of systemic and mucosal compartments, limiting tolerance opposing systemic antitumor efficacy. An unresolved issue surrounding self-antigens as immunotherapeutic targets is autoimmunity following systemic immunization. In the context of cancer mucosa antigens, immune effectors to self-antigens risk amplifying mucosal inflammatory disease promoting carcinogenesis. Here, we examined the relationship between immunotherapy for systemic colon cancer metastases targeting the intestinal cancer mucosa antigen guanylyl cyclase C (GCC) and its effect on inflammatory …

The Effects Of Mindfulness-Based Stress Reduction On Nurse Stress And Burnout: A Quantitative And Qualitative Study, Part Iii, Joanne Cohen-Katz, Susan Wiley, Terry Capuano, Debra Baker, Lynn Deitrick, Shauna Shapiro

Terry A Capuano MBA, MSN, RN, FACHE, NE-BC

No abstract provided.

Effectiveness And Tolerability Of Nevirapine, Stavudine, And Lamivudine In Clinical Practice, Joseph Yozviak, R Doerfler, William Woodward

Joseph L Yozviak DO, FACP

No abstract provided.

Resuppression Of Virus Load After Interruption In Treatment With Nevirapine And 2 Nucleoside Reverse-Transcriptase Inhibitors, Joseph Yozviak, R Doerfler, William Woodward

Joseph L Yozviak DO, FACP

No abstract provided.

Left Ventricular Diastolic Function And Exercise Capacity In Community-Dwelling Adults ≥65 Years Of Age Without Heart Failure, Gilbert Perry, Mustafa Ahmed, Ravi Desai, Marjan Mujib, Michael Zile, Xuemei Sui, Inmaculada Aban, Yan Zhang, Jose Tallaj, Richard Allman, Wilbert Aronow, Jerome Fleg, Ali Ahmed

Ravi V Desai MD

No abstract provided.

Boomerang-Shaped Heart In Isolated Dextroversion, Eddie Kim, Ravi Desai, Harish Doppalapudi, Steven Lloyd

Ravi V Desai MD

No abstract provided.

Impact Of Baseline Systolic Blood Pressure On Long-Term Outcomes In Patients With Advanced Chronic Systolic Heart Failure (Insights From The Best Trial), Ravi Desai, Maciej Banach, Mustafa Ahmed, Marjan Mujib, Inmaculada Aban, Thomas Love, Michel White, Gregg Fonarow, Prakash Deedwania, Wilbert Aronow, Ali Ahmed

Ravi V Desai MD

No abstract provided.

Mast Cell Stabilization Decreases Cardiomyocyte And Lv Function In Dogs With Isolated Mitral Regurgitation., Betty Pat, Cheryl Killingsworth, Yuanwen Chen, James D Gladden, Greg Walcott, Pamela C Powell, Thomas Denney, Himanshu Gupta, Ravi Desai, Michael Tillson, A Ray Dillon, Louis J Dell'italia

Ravi V Desai MD

BACKGROUND: Mast cells are increased in isolated mitral regurgitation (MR) in the dog and may mediate extracellular matrix loss and left ventricular (LV) dilatation. We tested the hypothesis that mast cell stabilization would attenuate LV remodeling and improve function in the MR dog.

METHODS AND RESULTS: MR was induced in adult dogs randomized to no treatment (MR, n = 5) or to the mast cell stabilizer, ketotifen (MR + MCS, n = 4) for 4 months. LV hemodynamics were obtained at baseline and after 4 months of MR and magnetic resonance imaging (MRI) was performed at sacrifice. MRI-derived, serial, short-axis …

Natural History Of Concentric Left Ventricular Geometry In Community-Dwelling Older Adults Without Heart Failure During Seven Years Of Follow-Up, Ravi Desai, Mustafa Ahmed, Marjan Mujib, Inmaculada Aban, Michael Zile, Ali Ahmed

Ravi V Desai MD

No abstract provided.

Absence Of Obesity Paradox In Patients With Chronic Heart Failure And Diabetes Mellitus: A Propensity-Matched Study, Chris Adamopoulos, Philippe Meyer, Ravi Desai, Kyparissi Karatzidou, Fernando Ovalle, Michel White, Inmaculada Aban, Thomas Love, Prakash Deedwania, Stefan Anker, Ali Ahmed

Ravi V Desai MD

No abstract provided.

Chymase Inhibition Prevents Fibronectin And Myofibrillar Loss And Improves Cardiomyocyte Function And Lv Torsion Angle In Dogs With Isolated Mitral Regurgitation., Betty Pat, Yuanwen Chen, Cheryl Killingsworth, James D Gladden, Ke Shi, Junying Zheng, Pamela C Powell, Greg Walcott, Mustafa I Ahmed, Himanshu Gupta, Ravi Desai, Chih-Chang Wei, Naoki Hase, Tsunefumi Kobayashi, Abdelkarim Sabri, Henk Granzier, Thomas Denney, Michael Tillson, A Ray Dillon, Ahsan Husain, Louis J Dell'italia

Ravi V Desai MD

BACKGROUND: The left ventricular (LV) dilatation of isolated mitral regurgitation (MR) is associated with an increase in chymase and a decrease in interstitial collagen and extracellular matrix. In addition to profibrotic effects, chymase has significant antifibrotic actions because it activates matrix metalloproteinases and kallikrein and degrades fibronectin. Thus, we hypothesize that chymase inhibitor (CI) will attenuate extracellular matrix loss and LV remodeling in MR.

METHODS AND RESULTS: We studied dogs with 4 months of untreated MR (MR; n=9) or MR treated with CI (MR+CI; n=8). Cine MRI demonstrated a >40% increase in LV end-diastolic volume in both groups, consistent with …

Effect Of Serum Insulin On The Association Between Hyperuricemia And Incident Heart Failure, Ravi Desai, Mustafa Ahmed, Gregg Fonarow, Gerasimos Filippatos, Michel White, Inmaculada Aban, Wilbert Aronow, Ali Ahmed

Ravi V Desai MD

No abstract provided.

Relation Of Baseline Systolic Blood Pressure And Long-Term Outcomes In Ambulatory Patients With Chronic Mild To Moderate Heart Failure, Maciej Banach, Vikas Bhatia, Margaret Feller, Marjan Mujib, Ravi Desai, Mustafa Ahmed, Jason Guichard, Inmaculada Aban, Thomas Love, Wilbert Aronow, Michel White, Prakash Deedwania, Gregg Fonarow, Ali Ahmed

Ravi V Desai MD

No abstract provided.

Warfarin Use And Outcomes In Patients With Advanced Chronic Systolic Heart Failure Without Atrial Fibrillation, Prior Thromboembolic Events, Or Prosthetic Valves, Marjan Mujib, Abu-Ahmed Rahman, Ravi Desai, Mustafa Ahmed, Margaret Feller, Inmaculada Aban, Tomas Love, Michel White, Prakash Deedwania, Wilbert Aronow, Gregg Fonarow, Ali Ahmed

Ravi V Desai MD

No abstract provided.