Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Cardiology Division (7)
- Department of Medicine (7)
- Department of Medicine Fellows and Residents (5)
- *Drug Resistance, Viral (1)
- *Mutation, Missense (1)
-
- Anti-HIV Agents (1)
- Antipsychotic Agents (1)
- Carbamates (1)
- Crystallography, X-Ray (1)
- Cyclin G1 (1)
- Dementia (1)
- Department of Emergency Medicine (1)
- Department of Emergency Medicine Faculty (1)
- Department of Psychiatry (1)
- Enzyme mechanisms (1)
- Ethanol (1)
- HIV Protease (1)
- HIV-1 (1)
- Hepacivirus (1)
- Humans (1)
- Inappropriate Prescribing (1)
- Kinetics (1)
- MicroRNAs (1)
- Models, Molecular (1)
- Mutant Proteins (1)
- Oligopeptides (1)
- Point Mutation (1)
- Protein Binding (1)
- Protein Conformation (1)
- Protein design (1)
Articles 1 - 13 of 13
Full-Text Articles in Medicine and Health Sciences
A Double-Blind, Randomized, Placebo-Controlled Trial Of Adjunctive Ramelteon For The Treatment Of Insomnia And Mood Stability In Patients With Euthymic Bipolar Disorder, Edward Norris, Karen Burke, Julia Correll, Ken Zemanek, Joel Lerman, Ralph Primelo, Michael Kaufmann
A Double-Blind, Randomized, Placebo-Controlled Trial Of Adjunctive Ramelteon For The Treatment Of Insomnia And Mood Stability In Patients With Euthymic Bipolar Disorder, Edward Norris, Karen Burke, Julia Correll, Ken Zemanek, Joel Lerman, Ralph Primelo, Michael Kaufmann
Edward R Norris MD, FAPA, FAPM
No abstract provided.
Venous Thromboembolism In Patients With Heart Failure: In-Hospital And Chronic Use Of Anti-Coagulants For Prevention, Nasir Shariff, Abdul Aleem, Vadim Levin, Sudip Nanda, Matthew Martinez, Stacey Smith, Ronald Freudenberger
Venous Thromboembolism In Patients With Heart Failure: In-Hospital And Chronic Use Of Anti-Coagulants For Prevention, Nasir Shariff, Abdul Aleem, Vadim Levin, Sudip Nanda, Matthew Martinez, Stacey Smith, Ronald Freudenberger
Vadim A Levin MD
No abstract provided.
Ranolazine—Treatment Of Ventricular Tachycardia And Symptomatic Ventricular Premature Beats In Ischemic Cardiomyopathy, Sudip Nanda, Vadim Levin, Matthew Martinez, Ronald Freudenberger
Ranolazine—Treatment Of Ventricular Tachycardia And Symptomatic Ventricular Premature Beats In Ischemic Cardiomyopathy, Sudip Nanda, Vadim Levin, Matthew Martinez, Ronald Freudenberger
Vadim A Levin MD
No abstract provided.
Novel Oral Anticoagulants For Stroke Prevention In Patients With Atrial Fibrillation: Dawn Of A New Era, Tahmeed Contractor, Vadim Levin, Matthew Martinez, Francis Marchinski
Novel Oral Anticoagulants For Stroke Prevention In Patients With Atrial Fibrillation: Dawn Of A New Era, Tahmeed Contractor, Vadim Levin, Matthew Martinez, Francis Marchinski
Vadim A Levin MD
No abstract provided.
Warfarin Use And Outcomes In Patients With Advanced Chronic Systolic Heart Failure Without Atrial Fibrillation, Prior Thromboembolic Events, Or Prosthetic Valves, Marjan Mujib, Abu-Ahmed Rahman, Ravi Desai, Mustafa Ahmed, Margaret Feller, Inmaculada Aban, Tomas Love, Michel White, Prakash Deedwania, Wilbert Aronow, Gregg Fonarow, Ali Ahmed
Warfarin Use And Outcomes In Patients With Advanced Chronic Systolic Heart Failure Without Atrial Fibrillation, Prior Thromboembolic Events, Or Prosthetic Valves, Marjan Mujib, Abu-Ahmed Rahman, Ravi Desai, Mustafa Ahmed, Margaret Feller, Inmaculada Aban, Tomas Love, Michel White, Prakash Deedwania, Wilbert Aronow, Gregg Fonarow, Ali Ahmed
Ravi V Desai MD
No abstract provided.
Influence Of Co-Existing Atrial Fibrillation On The Efficacy Of Atorvastatin Treatment In Patients With Dilated Cardiomyopathy: A Pilot Study, Agata Bielecka-Dabrowa, Jan Goch, Jacek Rysz, Marek Maciejewski, Ravi Desai, Wilbert Aronow
Influence Of Co-Existing Atrial Fibrillation On The Efficacy Of Atorvastatin Treatment In Patients With Dilated Cardiomyopathy: A Pilot Study, Agata Bielecka-Dabrowa, Jan Goch, Jacek Rysz, Marek Maciejewski, Ravi Desai, Wilbert Aronow
Ravi V Desai MD
No abstract provided.
Relationship Between Left And Right Ventricular Ejection Fractions In Chronic Advanced Systolic Heart Failure: Insights From The Best Trial, Ravi Desai, Philippe Meyer, Mustafa Ahmed, Marjan Mujib, Chris Adamopoulos, Michel White, Inmaculada Aban, Ami Iskandrian, Ali Ahmed
Relationship Between Left And Right Ventricular Ejection Fractions In Chronic Advanced Systolic Heart Failure: Insights From The Best Trial, Ravi Desai, Philippe Meyer, Mustafa Ahmed, Marjan Mujib, Chris Adamopoulos, Michel White, Inmaculada Aban, Ami Iskandrian, Ali Ahmed
Ravi V Desai MD
No abstract provided.
Effect Of Warfarin On Outcomes In Septuagenarian Patients With Atrial Fibrillation, Brita Roy, Ravi Desai, Marjan Mujib, Andrew Epstein, Yan Zhang, Jason Guichard, Linda Jones, Margaret Feller, Mustafa Ahmed, Inmaculada Aban, Thomas Love, Michel White, Wilbert Aronow, Ali Ahmed
Effect Of Warfarin On Outcomes In Septuagenarian Patients With Atrial Fibrillation, Brita Roy, Ravi Desai, Marjan Mujib, Andrew Epstein, Yan Zhang, Jason Guichard, Linda Jones, Margaret Feller, Mustafa Ahmed, Inmaculada Aban, Thomas Love, Michel White, Wilbert Aronow, Ali Ahmed
Ravi V Desai MD
No abstract provided.
Alcohol Facilitates Hcv Rna Replication Via Up-Regulation Of Mir-122 Expression And Inhibition Of Cyclin G1 In Human Hepatoma Cells, Wei Hou, Terence Bukong, Karen Kodys, Gyongyi Szabo
Alcohol Facilitates Hcv Rna Replication Via Up-Regulation Of Mir-122 Expression And Inhibition Of Cyclin G1 In Human Hepatoma Cells, Wei Hou, Terence Bukong, Karen Kodys, Gyongyi Szabo
Gyongyi Szabo
BACKGROUND: Clinical studies demonstrate synergistic liver damage by alcohol and hepatitis C virus (HCV); however, the mechanisms by which alcohol promotes HCV infection remain obscure. The liver-specific microRNA-122 (miR-122) regulates HCV replication and expression of host genes, including Cyclin G1. Here, we hypothesized that alcohol regulates miR-122 expression and thereby modulates HCV RNA replication. METHODS: The J6/JFH/Huh-7.5 model of HCV infection was used in this study. Real-time quantitative polymerase chain reaction, Western blotting, electrophoretic mobility shift assay, and confocal microscopy were used for experimental analysis. RESULTS: We found that acute alcohol exposure (25 mM) significantly increased intracellular HCV RNA as …
Structural And Thermodynamic Basis Of Amprenavir/Darunavir And Atazanavir Resistance In Hiv-1 Protease With Mutations At Residue 50, Seema Mittal, Rajintha Bandaranayake, Nancy King, Moses Prabu-Jeyabalan, Madhavi Nalam, Ellen Nalivaika, Nese Yilmaz, Celia Schiffer
Structural And Thermodynamic Basis Of Amprenavir/Darunavir And Atazanavir Resistance In Hiv-1 Protease With Mutations At Residue 50, Seema Mittal, Rajintha Bandaranayake, Nancy King, Moses Prabu-Jeyabalan, Madhavi Nalam, Ellen Nalivaika, Nese Yilmaz, Celia Schiffer
Celia A. Schiffer
Drug resistance occurs through a series of subtle changes that maintain substrate recognition but no longer permit inhibitor binding. In HIV-1 protease, mutations at I50 are associated with such subtle changes that confer differential resistance to specific inhibitors. Residue I50 is located at the protease flap tips, closing the active site upon ligand binding. Under selective drug pressure, I50V/L substitutions emerge in patients, compromising drug susceptibility and leading to treatment failure. The I50V substitution is often associated with amprenavir (APV) and darunavir (DRV) resistance, while the I50L substitution is observed in patients failing atazanavir (ATV) therapy. To explain how APV, …
Potentially Inappropriate Use Of Antipsychotics In Community-Dwelling Adults With Dementia More Common In Those With Low Income, Jennifer Tjia
Potentially Inappropriate Use Of Antipsychotics In Community-Dwelling Adults With Dementia More Common In Those With Low Income, Jennifer Tjia
Jennifer Tjia
Comment on: The essential and potentially inappropriate use of antipsychotics across income groups: an analysis of linked administrative data. [Can J Psychiatry. 2012]
Compliance With The Centers For Disease Control And Prevention Recommendations For The Diagnosis And Treatment Of Sexually Transmitted Diseases, Bryan Kane, Linda Degutis, Helen Sayward, Gail D'Onofrio
Compliance With The Centers For Disease Control And Prevention Recommendations For The Diagnosis And Treatment Of Sexually Transmitted Diseases, Bryan Kane, Linda Degutis, Helen Sayward, Gail D'Onofrio
Bryan G Kane MD
No abstract provided.
Structure And Dynamics Of A Primordial Catalytic Fold Generated By In Vitro Evolution, Fa-An Chao, Aleardo Morelli, John C. Haugner Iii, Lewis Churchfield, Lei Shi, Larry R. Masterson, Ritimukta Sarangi, Gianluigi Veglia, Burckhard Seelig
Structure And Dynamics Of A Primordial Catalytic Fold Generated By In Vitro Evolution, Fa-An Chao, Aleardo Morelli, John C. Haugner Iii, Lewis Churchfield, Lei Shi, Larry R. Masterson, Ritimukta Sarangi, Gianluigi Veglia, Burckhard Seelig
Larry Masterson