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Full-Text Articles in Medicine and Health Sciences
Gonadotropins And Cognition In Older Women, Mark Rodrigues, Giuseppe Verdile, Jonathan Foster, Eva Hogervorst, Karen Joesbury, Satvinder Dhaliwal, Elizabeth Corder, Simon Laws, Eugene Hone, Richard Prince, Amanda Devine, Pankaj Mehta, John Beilby, Craig Atwood, Ralph Martins
Gonadotropins And Cognition In Older Women, Mark Rodrigues, Giuseppe Verdile, Jonathan Foster, Eva Hogervorst, Karen Joesbury, Satvinder Dhaliwal, Elizabeth Corder, Simon Laws, Eugene Hone, Richard Prince, Amanda Devine, Pankaj Mehta, John Beilby, Craig Atwood, Ralph Martins
Simon Laws
Recent research studies associate elevated gonadotropin levels with dementia. Specifically, an age associated increase in levels of luteinizing hormone has been linked to an increased risk of Alzheimer's disease. The objective of this study was to investigate the association between gonadotropin levels and cognition in older, healthy postmenopausal women. Cognitive functioning was compared with plasma levels of estradiol, luteinizing hormone, follicle stimulating hormone, Aβ40 and APOE genetic status in 649 community-dwelling, non-demented older women residing in Western Australia. High endogenous luteinizing hormone levels were associated with a lower cognitive score, especially in older women and in those women that were …
Tnf Polymorphisms In Alzheimer Disease And Functional Implications On Csf Beta-Amyloid Levels, Simon Laws, Robert Perneczky, Stefan Wagenpfeil, Ulrich Muller, Hans Forstl, Ralph Martins, Alexander Kurz, Matthias Riemenschneider
Tnf Polymorphisms In Alzheimer Disease And Functional Implications On Csf Beta-Amyloid Levels, Simon Laws, Robert Perneczky, Stefan Wagenpfeil, Ulrich Muller, Hans Forstl, Ralph Martins, Alexander Kurz, Matthias Riemenschneider
Simon Laws
Alzheimer disease (AD), vascular dementia, and stroke are all associated with inflammation though their respective initiating factors differ. Recently a polymorphism in the proinflammatory cytokine tumor necrosis factor (TNF), in association with apolipoprotein E (APOE), was reported to increase AD risk. Two SNPs, rs1799724 (–850C>T; NT_007592.14:g.22400733C>T) and rs1800629 (–308G>A; [NT_007592.14:g.22401282G>A]), and the APOE polymorphism were genotyped in 506 patients with sporadic AD and in 277 cognitively healthy controls. In a subset of 90 individuals we also investigated whether these SNPs exerted any functional effects on cerebrospinal fluid (CSF) beta-amyloid (Aβ) levels. The frequency of the rs1799724 …