Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Be (2)
- Poisoning (2)
- 1 (1)
- 2 (1)
- 3 (1)
-
- Acetaminophen (1)
- Acetylcysteine (1)
- Acute (1)
- Added (1)
- Associated (1)
- Case (1)
- Cautious (1)
- Dimercatopropane (1)
- Every (1)
- Failure (1)
- Haemodiafiltration (1)
- Late (1)
- Liver (1)
- Mercuric (1)
- Methionine (1)
- More (1)
- N (1)
- Need (1)
- Paracetamol (1)
- Prolonged (1)
- Report (1)
- Severe (1)
- Should (1)
- Sulphate (1)
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Should Methionine Be Added To Every Paracetamol Tablet?, Alison Jones, P Hayes, A Proudfoot, J Vale, L Prescott
Should Methionine Be Added To Every Paracetamol Tablet?, Alison Jones, P Hayes, A Proudfoot, J Vale, L Prescott
Alison L Jones
Paracetamol is commonly used for self poisoning, and the costs of treating the resulting liver failure in the few who develop it are high. The morbidity could be avoided by adding methionine to paracetamol tablets, but this would mean that the millions of people who take paracetamol responsibly would have to take methionine unnecessarily. Alison Jones and colleagues and Edward Krenzelok debate the issue.
Case Report: Severe Mercuric Sulphate Poisoning Treated With 2,3-Dimercatopropane-1-Sulphonate And Haemodiafiltration, Paul Dargan, Lucy Giles, Craig Wallace, Ivan House, Alison Thomson, Richard Beale, Alison Jones
Case Report: Severe Mercuric Sulphate Poisoning Treated With 2,3-Dimercatopropane-1-Sulphonate And Haemodiafiltration, Paul Dargan, Lucy Giles, Craig Wallace, Ivan House, Alison Thomson, Richard Beale, Alison Jones
Alison L Jones
No abstract provided.
Prolonged N-Acetylcysteine Therapy In Late Acetaminophen Poisoning Associated With Acute Liver Failure--A Need To Be More Cautious?, T Nimmi, C Athuraliya, Alison Jones
Prolonged N-Acetylcysteine Therapy In Late Acetaminophen Poisoning Associated With Acute Liver Failure--A Need To Be More Cautious?, T Nimmi, C Athuraliya, Alison Jones
Alison L Jones
Since the 1970s, N-acetylcysteine (NAC) has shown proven efficacy as an antidote for acetaminophen (APAP) poisoning and APAP-induced liver failure for early presenters. The current evidence of benefits of NAC for late presenters is controversial because of the poor understanding of the mechanism of late toxicity. In the previous issue of Critical Care, Yang and colleagues use a mouse model to demonstrate that NAC in doses similar to those used therapeutically to treat APAP poisoning in humans impairs liver regenerative capacity and that the effect is more pronounced when administered for a longer duration. Studies based on cell cultures support …