Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Hiv/Aids Research Symposium, College Of The Holy Cross
Hiv/Aids Research Symposium, College Of The Holy Cross
LGBTQIA Archive: Posters
Poster detailing planned events of the HIV/AIDS Research Symposium, held November 29-December 2, 2023 at the College of the Holy Cross. In observance of the 35th World AIDS Day, the Holy Cross LGBTQ+ Alumni Network and a multidisciplinary faculty team invited a broad ranging conversation about the historical and current impact and intersection of the HIV/AIDS pandemic on both the Holy Cross community and the wider world.
Various Synthetic Pathways Towards Efavirenz And Its Analogs; The Replacement Of The Side Chain, Elizabeth S. Bautista
Various Synthetic Pathways Towards Efavirenz And Its Analogs; The Replacement Of The Side Chain, Elizabeth S. Bautista
Selected Honors Theses
Cyclopropyl acetylene (CA) is a key intermediate in the synthesis of the human immunodeficiency virus (HIV) reverse transcriptase inhibitor, Efavirenz (EFV), an antiviral drug used to treat HIV. CA is an expensive raw material, difficult to obtain, and employed in the preparation of medications to combat acquired immunodeficiency syndrome (AIDS). It was found that the structure could be synthesized by the utilization of PCl5; however, this resulted in unwanted ring opening products. To address this issue, a one pot synthesis was developed using Ph3PCl2 as a mild chlorinating agent. In addition, a new analog has been proposed substituting the cyclopropyl …
Modeling Immune System Dynamics During Hiv Infection And Treatment With Differential Equations, Nicole Rychagov
Modeling Immune System Dynamics During Hiv Infection And Treatment With Differential Equations, Nicole Rychagov
CODEE Journal
An inquiry-based project that discusses immune system dynamics during HIV infection using differential equations is presented. The complex interactions between healthy T-cells, latently infected T-cells, actively infected T-cells, and the HIV virus are modeled using four nonlinear differential equations. The model is adapted to simulate long term HIV dynamics, including the AIDS state, and is used to simulate the long term effects of the traditional antiretroviral therapy (ART). The model is also used to test viral rebound over time of combined application of ART and a new drug that blocks the reactivation of the viral genome in the infected cells …