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Full-Text Articles in Medicine and Health Sciences
Gp3 Is A Structural Component Of The Prrsv Type Ii (Us) Virion, M. De Lima, I. H. Ansari, P. B. Das, B. J. Ku, F. J. Martinez-Lobo, Fernando A. Osorio
Gp3 Is A Structural Component Of The Prrsv Type Ii (Us) Virion, M. De Lima, I. H. Ansari, P. B. Das, B. J. Ku, F. J. Martinez-Lobo, Fernando A. Osorio
School of Veterinary and Biomedical Sciences: Faculty Publications
Abstract Glycoprotein 3 (GP3) is a highly glycosylated PRRSV envelope protein which has been reported as being present in the virions of PRRSV type I, while missing in the type II PRRSV (US) virions. We herein present evidence that GP3 is indeed incorporated in the virus particles of a North American strain of PRRSV (FL12), at a density that is consistent with the minor structural role assigned to GP3 in members of the Arterivirus genus. Two 15aa peptides corresponding to two different immunodominant linear epitopes of GP3 derived from the North American strain of PRRSV (FL12) were used as antigen …
Mouse × Pig Chimeric Antibodies Expressed In Baculovirus Retain The Same Properties Of Their Parent Antibodies, Ana M. Jar, Fernando A. Osorio, Osvaldo J. López
Mouse × Pig Chimeric Antibodies Expressed In Baculovirus Retain The Same Properties Of Their Parent Antibodies, Ana M. Jar, Fernando A. Osorio, Osvaldo J. López
School of Veterinary and Biomedical Sciences: Faculty Publications
The development of hybridoma and recombinant DNA technologies has made it possible to use antibodies against cancer, autoimmune disorders, and infectious diseases in humans. These advances in therapy, as well as immunoprophylaxis, could also make it possible to use these technologies in agricultural species of economic importance such as pigs. Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus causing very important economic losses to the industry. Passive transfer of antibodies obtained by biotechnology could be used in the future to complement or replace vaccination against this and other pig pathogens. To this end, we constructed and studied the …