Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 12 of 12
Full-Text Articles in Medicine and Health Sciences
Animal Models And Therapeutic Molecular Targets Of Cancer: Utility And Limitations., Maria Cekanova Ms, Rndr, Phd, Kusum Rathore
Animal Models And Therapeutic Molecular Targets Of Cancer: Utility And Limitations., Maria Cekanova Ms, Rndr, Phd, Kusum Rathore
Maria Cekanova MS, RNDr, PhD
Cancer is the term used to describe over 100 diseases that share several common hallmarks. Despite prevention, early detection, and novel therapies, cancer is still the second leading cause of death in the USA. Successful bench-to-bedside translation of basic scientific findings about cancer into therapeutic interventions for patients depends on the selection of appropriate animal experimental models. Cancer research uses animal and human cancer cell lines in vitro to study biochemical pathways in these cancer cells. In this review, we summarize the important animal models of cancer with focus on their advantages and limitations. Mouse cancer models are well known, …
Mycobacterium Ulcerans Fails To Infect Through Skin Abrasions In A Guinea Pig Infection Model: Implications For Transmission, H R. Williamson, L Mosi, Robert L. Donnell, M Aqqad, R W. Merritt, P L. Small
Mycobacterium Ulcerans Fails To Infect Through Skin Abrasions In A Guinea Pig Infection Model: Implications For Transmission, H R. Williamson, L Mosi, Robert L. Donnell, M Aqqad, R W. Merritt, P L. Small
Robert L Donnell DVM, Ph.D., DACVP College of Veterinary Medicine
Transmission of M. ulcerans, the etiological agent of Buruli ulcer, from the environment to humans remains an enigma despite decades of research. Major transmission hypotheses propose 1) that M. ulcerans is acquired through an insect bite or 2) that bacteria enter an existing wound through exposure to a contaminated environment. In studies reported here, a guinea pig infection model was developed to determine whether Buruli ulcer could be produced through passive inoculation of M. ulcerans onto a superficial abrasion. The choice of an abrasion model was based on the fact that most bacterial pathogens infecting the skin are able to …
Magnetic Resonance Imaging (Mri) Spinal Cord And Canal Measurements In Normal Dogs, Silke Hecht, M M. Huerta, Robert B. Reed
Magnetic Resonance Imaging (Mri) Spinal Cord And Canal Measurements In Normal Dogs, Silke Hecht, M M. Huerta, Robert B. Reed
Silke Hecht
The goal of this study was to establish Magnetic resonance imaging (MRI) reference ranges for spinal measurements in normal dogs. Forty dogs (1–10 kg, 11–20 kg, 21–30 kg, > 30 kg; 10 dogs per category) underwent spinal MRI. Measurements were performed on sagittal T2-W images at the level of the 4th thoracic vertebra (T4), the 9th thoracic vertebra (T9) and the 3rd lumbar vertebra (L3). Spinal canal diameter (mm) ranged from 6.07 ± 0.63 (1–10 kg) to 8.27 ± 1.15 (> 30 kg) at the level of T4; 6.55 ± 0.61 (1–10 kg) to 9.04 ± 1.26 (> 30 kg) at …
Chimeric Protein A/G Conjugate For Detection Of Anti–Toxoplasma Gondii Immunoglobulin G In Multiple Animal Species, John J. Schaefer, Holly A. White, Stephanie L. Schaaf, Hussni O. Mohammed, Susan E. Wade
Chimeric Protein A/G Conjugate For Detection Of Anti–Toxoplasma Gondii Immunoglobulin G In Multiple Animal Species, John J. Schaefer, Holly A. White, Stephanie L. Schaaf, Hussni O. Mohammed, Susan E. Wade
John J Schaefer
Serological testing for toxoplasmosis diagnosis remains the method of choice in human medicine due to the accessibility of the requisite sample, the difficulty in predicting the parasite’s location in the host for direct detection, and the availability of established commercial methods. In veterinary medicine, although the first 2 conditions are unchanged, there is a need for commercially produced test methods that are validated for Toxoplasma gondii detection across the range of animal species that can serve as intermediate hosts. The development of such a serological method for animals would allow the diagnosis of toxoplasmosis in individual animals and a higher …
Modification Of A Commercial Toxoplasma Gondii Immunoglobulin G Enzyme-Linked Immunosorbent Assay For Use In Multiple Animal Species, John J. Schaefer, Holly A. White, Stephanie L. Schaaf, Hussni O. Mohammed, Susan E. Wade
Modification Of A Commercial Toxoplasma Gondii Immunoglobulin G Enzyme-Linked Immunosorbent Assay For Use In Multiple Animal Species, John J. Schaefer, Holly A. White, Stephanie L. Schaaf, Hussni O. Mohammed, Susan E. Wade
John J Schaefer
A challenge faced by veterinary diagnosticians in serologic analysis for exposure to pathogens is the need for a protein conjugate capable of antibody attachment in many animal species. The advent of protein conjugates that are less specific in nature allows diagnosis across many species with little or no modification of technique. Toxoplasma gondii is an organism of veterinary interest that has been demonstrated to infect a plethora of warm-blooded animals. However, the serologic tests available for simultaneous diagnosis in this broad range are limited in number. The current study examined the use of an immunoglobulin G enzyme-linked immunosorbent assay (ELISA) …
Efficacy Of A Doxycycline Treatment Regimen Initiated During Three Different Phases Of Experimental Ehrlichiosis, Jennifer C. Mcclure, Michelle L. Crothers, John J. Schaefer, Patrick D. Stanley, Glen R. Needham, S A. Ewing, Roger W. Stich
Efficacy Of A Doxycycline Treatment Regimen Initiated During Three Different Phases Of Experimental Ehrlichiosis, Jennifer C. Mcclure, Michelle L. Crothers, John J. Schaefer, Patrick D. Stanley, Glen R. Needham, S A. Ewing, Roger W. Stich
John J Schaefer
Doxycycline is the treatment of choice for canine monocytic ehrlichiosis (CME), a well-characterized disease and valuable model for tick-borne zoonoses. Conflicting reports of clearance of Ehrlichia canis after treatment with doxycycline suggested that the disease phase during which treatment is initiated influences outcomes of these treatments. The purpose of this study was to evaluate the efficacy of a 28-day doxycycline regimen for clearance of experimental E. canis infections from dogs treated during three phases of the disease. Ten dogs were inoculated with blood from E. canis carriers and treated with doxycycline during acute, subclinical, or chronic phases of CME. Daily …
Microarray Analysis Demonstrates A Role For Slug In Epidermal Homeostatsis, Kim M. Newkirk
Microarray Analysis Demonstrates A Role For Slug In Epidermal Homeostatsis, Kim M. Newkirk
Kim M Newkirk
No abstract provided.
The Acute Cutaneous Inflammatory Response Is Attenuated In Slug Knockout Mice. Newkirk K, Duncan F, Brannick E, Chandler H, Parent A, Kusewitt D., Kim M. Newkirk
Kim M Newkirk
No abstract provided.
Ultraviolet Radiation Stimulates Expression Of Snail Family Transcription Factors In Keratinocytes. Hudson L, Choi C, Newkirk K, Parkhani J, Cooper K, Lu P, Kusewitt D, Kim M. Newkirk
Kim M Newkirk
No abstract provided.
Uveal Spindle Cell Tumor Of Blue-Eyed Dogs: An Immunohistochemical Study. Zarfoss M, Klauss G, Newkirk K, Kiupel M, Jones Y, Colitz C, Weisbrode S, Kusewitt D, Dubielzig R., Kim M. Newkirk
Kim M Newkirk
No abstract provided.
Snai2 Expression Enhances Uvr-Induced Skin Carcinogenesis. Newkirk K, Parent A, Fossey S, Choi C, Chandler H Rajala-Schultz P, Kusewitt D., Kim M. Newkirk
Snai2 Expression Enhances Uvr-Induced Skin Carcinogenesis. Newkirk K, Parent A, Fossey S, Choi C, Chandler H Rajala-Schultz P, Kusewitt D., Kim M. Newkirk
Kim M Newkirk
No abstract provided.
Ultraviolet Radiation Exposure Induces Corneal Degeneration In 129 Mice. Newkirk K, Chandler H, Parent A, Young D, Colitz C, Wilkie D, Kusewitt D, Kim M. Newkirk
Kim M Newkirk
No abstract provided.