Medicine and Health Sciences Commons^™

The Effect Of Il-6 On Satellite Cell Activity In Tumor Bearing Mice

samuel.lambert@uconn.edu

Cancer cachexia results in severe muscle atrophy and can greatly hinder the quality of life and chances of survival for the afflicted individual. In studies where cachexia-induced muscle atrophy is inhibited, survival is prolonged. The activity of satellite cells, the muscle progenitor cells that incorporate into muscle fibers to cause hypertrophy, is the focus of this study. It was hypothesized that mRNA expression of Pax7, MyoD, FoxO1, FoxO3a, and FoxO4 would be altered in injured muscle in TB animals, and this would be attenuated by inhibition of interleukin (IL)-6 signaling. To test this hypothesis, tumor bearing (TB) and control mice …