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Efficacy Of Intravenous Administration Of Combined Acid Suppressants In Healthy Dogs, M Tolbert, Adesola Odunayo, R Howell, E Peters, Ann Reed

M Katherine Tolbert DVM, PhD, DACVIM

Background Short-term intravenous co-administration of famotidine and pantoprazole is used by some veterinarians to treat gastrointestinal bleeding in critically ill dogs. However, clinical studies have not evaluated the efficacy of combination acid suppressant treatment in dogs.

Hypothesis/Objectives To compare the effect of intravenous co-administration of famotidine and pantoprazole to monotherapy with pantoprazole on intragastric pH in dogs. We hypothesized that single agent pantoprazole would be more effective than combination with famotidine.

Animals Twelve healthy adult colony dogs.

Methods Randomized, 2-way crossover design. All dogs received placebo (0.9% saline) for 24 hours followed by 1.0 mg/kg IV q12h pantoprazole or combination …

Evaluation Of The Effect Of Orally Administered Acid Suppressants On Intragastric Ph In Cats, S Parkinson, M Katherine Tolbert, K Messenger, A. Odunayo, M. Brand, G. Davidson, E. Peters, A. Reed, M. G. Papich

M Katherine Tolbert DVM, PhD, DACVIM

Background Acid suppressant drugs are a mainstay of treatment for cats with gastrointestinal erosion and ulceration. However, clinical studies have not been performed to compare the efficacy of commonly PO administered acid suppressants in cats.

Hypothesis/Objectives To compare the effect of PO administered famotidine, fractionated omeprazole tablet (fOT), and omeprazole reformulated paste (ORP) on intragastric pH in cats. We hypothesized that both omeprazole formulations would be superior to famotidine and placebo.

Animals Six healthy adult DSH colony cats.

Methods Utilizing a randomized, 4-way crossover design, cats received 0.88–1.26 mg/kg PO q12h fOT, ORP, famotidine, and placebo (lactose capsules). Intragastric pH …

Exogenous Sialic Acid And Cysteine Protease Inhibition Block Aherence Of Tritrichomonas Foetus To The Intestinal Epithelium, M Katherine Tolbert, J L. Gookin

M Katherine Tolbert DVM, PhD, DACVIM

No abstract provided.

Efficacy Of Oral Famotidine And 2 Omeprazole Formulations For The Control Of Intragastric Ph In Dogs, K Tolbert, S Bissett, A King, G Davidson, M Papich, E Peters, L Degernes

M Katherine Tolbert DVM, PhD, DACVIM

BACKGROUND: Little is known about the efficacy of commonly used acid suppressants on intragastric pH in dogs. OBJECTIVE: To compare the effect of oral famotidine, 2 formulations of omeprazole, and placebo on intragastric pH in dogs with a catheter-free, continuous pH monitoring system. ANIMALS: Six healthy adult mixed-breed colony dogs. METHODS: Utilizing a randomized, 4-way cross over, open-label study, dogs were administered famotidine PO (1.0-1.3 mg/kg q12h), omeprazole tablet (1.5-2.6 mg/kg q24h), omeprazole reformulated paste (RP) (Gastrogard, 1.5-2.6 mg/kg q24h), and placebo for 7 days followed by a 10-day washout period. Radiotelemetric pH capsules were placed with gastroscopy assistance to …

Efficacy Of Oral Famotidine And 2 Omeprazole Formulations For The Control Of Intragastric Ph In Dogs, M Katherine Tolbert, S Bissett, A King, G Davidson, M Papich, E Peters, L Degernes

M Katherine Tolbert DVM, PhD, DACVIM

No abstract provided.