Medicine and Health Sciences Commons^™

Efficacy Of Intravenous Administration Of Combined Acid Suppressants In Healthy Dogs, M Tolbert, Adesola Odunayo, R Howell, E Peters, Ann Reed

M Katherine Tolbert DVM, PhD, DACVIM

Background Short-term intravenous co-administration of famotidine and pantoprazole is used by some veterinarians to treat gastrointestinal bleeding in critically ill dogs. However, clinical studies have not evaluated the efficacy of combination acid suppressant treatment in dogs.

Hypothesis/Objectives To compare the effect of intravenous co-administration of famotidine and pantoprazole to monotherapy with pantoprazole on intragastric pH in dogs. We hypothesized that single agent pantoprazole would be more effective than combination with famotidine.

Animals Twelve healthy adult colony dogs.

Methods Randomized, 2-way crossover design. All dogs received placebo (0.9% saline) for 24 hours followed by 1.0 mg/kg IV q12h pantoprazole or combination …

Maintenance Energy Requirements Of Odor Detection, Explosive Detection And Human Detection Working Dogs, Rebecca A. Mullis, Angela L. Witzel, Joshua Price

Angela L Witzel (Lusby) DVM, PhD, DACVN

Despite their important role in security, little is known about the energy requirements of working dogs such as odor, explosive and human detection dogs. Previous researchers have evaluated the energy requirements of individual canine breeds as well as dogs in exercise roles such as sprint racing. This study is the first to evaluate the energy requirements of working dogs trained in odor, explosive and human detection. This retrospective study evaluated twenty adult dogs who maintained consistent body weights over a six month period. During this time, the average energy consumption was [Formula: see text] or two times the calculated resting …

Randomized Phase Iii Trial Of Piroxicam In Combination With Mitoxantrone Or Carboplatin For First-Line Treatment Of Urogenital Tract Transitional Cell Carcinoma In Dogs., Sara D. Allstadt, C O. Rodriquez, B Boostrom, R B. Rebhun, K A. Skorupski

Sara Allstadt, DVM, Diplomate ACVIM (Oncology)

BACKGROUND: Reported response rates of transitional cell carcinoma (TCC) in dogs to piroxicam in combination with either mitoxantrone or carboplatin are similar; however, it is unknown whether either drug might provide superior duration of response. HYPOTHESIS/OBJECTIVES: To determine if the progression-free interval (PFI) of dogs with TCC treated with mitoxantrone and piroxicam was different than that of dogs receiving carboplatin and piroxicam. The hypothesis was that the efficacy of mitoxantrone is no different from carboplatin. ANIMALS: Fifty dogs with TCC without azotemia. METHODS: Prospective open-label phase III randomized study. Either mitoxantrone or carboplatin was administered every 3 weeks concurrently with …

C.A.R.E.S. (Canine Arthritis, Rehabilitation, Exercise, And Sports Medicine) Newsletter, Darryl L. Millis

Darryl L. Millis

No abstract provided.

Evaluation Of A Semiquantitative Snap Test For Measurement Of Bile Acids In Dogs, Rachel L. Seibert, Karen M. Tobias, Ann Reed, Karl R. Snyder

Ann Reed

Background. Serum bile acids (SBA) are used as a routine screening tool of liver function in dogs. Serum samples are usually shipped to a referral laboratory for quantitative analysis with an enzymatic chemistry analyzer. The canine SNAP Bile Acids Test (SNAP-BAT) provides an immediate, semi-quantitative measurement of bile acid concentrations in-house. With the SNAP-BAT, bile acids concentrations of 5–30 µmol/L are quantified, and results outside of that range are classified as <5 or >30 µmol/L. Agreement of the SNAP-BAT with the enzymatic method has not been extensively investigated.

Objectives. The purposes of this prospective clinical study were to assess the precision of …

Evaluation Of A Semiquantitative Snap Test For Measurement Of Bile Acids In Dogs, Rachel L. Seibert, Karen M. Tobias, Ann Reed, Karl R. Snyder

Karen M. Tobias DVM, DACVS, College of Veterinary Medicine

Background. Serum bile acids (SBA) are used as a routine screening tool of liver function in dogs. Serum samples are usually shipped to a referral laboratory for quantitative analysis with an enzymatic chemistry analyzer. The canine SNAP Bile Acids Test (SNAP-BAT) provides an immediate, semi-quantitative measurement of bile acid concentrations in-house. With the SNAP-BAT, bile acids concentrations of 5–30 µmol/L are quantified, and results outside of that range are classified as <5 or >30 µmol/L. Agreement of the SNAP-BAT with the enzymatic method has not been extensively investigated. Objectives. The purposes of this prospective clinical study were to assess the precision of …