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Full-Text Articles in Medicine and Health Sciences
Lung And Nasal Lesions Caused By A Swine Chlamydial Isolate In Gnotobiotic Pigs, Douglas G. Rogers, Arthur A. Andersen, Breck D. Hunsaker
Lung And Nasal Lesions Caused By A Swine Chlamydial Isolate In Gnotobiotic Pigs, Douglas G. Rogers, Arthur A. Andersen, Breck D. Hunsaker
School of Veterinary and Biomedical Sciences: Faculty Publications
The objective of this study was to determine whether a chlamydial isolate recovered from nasal swabs from swine with pneumonia could cause pneumonia and rhinitis in gnotobiotic pigs. The identity of the isolate currently is unknown, but it shares characteristics with Chlamydia trachomatis. After propagation in Vero cells and preparation of the inoculum (2.5 x 1010 inclusion-forming units/ml), Chlamydiae were instilled into nostrils (1.0 ml/nostril) and lungs (2.0 ml intralaryngeally) of 15 anesthetized 3-day-old gnotobiotic piglets. Five age-matched gnotobiotic piglets were anesthetized and sham infected with uninfected cell culture lysates. Two treated piglets were moribund and 2 were severely …
Intestinal Lesions Caused By Two Swine Chlamydial Isolates In Gnotobiotic Pigs, Douglas G. Rogers, Arthur A. Andersen
Intestinal Lesions Caused By Two Swine Chlamydial Isolates In Gnotobiotic Pigs, Douglas G. Rogers, Arthur A. Andersen
School of Veterinary and Biomedical Sciences: Faculty Publications
The objective of this study was to determine whether 2 distinct chlamydial isolates recovered from the intestines and feces of diarrheic nursery pigs could cause intestinal lesions in gnotobiotic pigs. Both isolates share biological characteristics with Chlamydia trachomatis. Chlamydial isolates R27 and R19 were propagated in Vero cells or embryonated eggs, respectively, and suspended in sucrose-phosphate-glutamine buffer with 10% fetal bovine serum for inoculation. Sham inocula were prepared from uninfected cell culture lysates and from uninfected eggs. Each piglet was fed 1 ml of inoculum or sham inoculum at 3-4 days of age. Ten piglets were each fed 10 …
The Latency-Related Gene Of Bovine Herpesvirus 1 Encodes A Product Which Inhibits Cell Cycle Progression, L. M. Schang, Ashfaque Hossain, Clinton J. Jones
The Latency-Related Gene Of Bovine Herpesvirus 1 Encodes A Product Which Inhibits Cell Cycle Progression, L. M. Schang, Ashfaque Hossain, Clinton J. Jones
School of Veterinary and Biomedical Sciences: Faculty Publications
Bovine herpesvirus 1 (BHV-1) establishes a latent infection in the sensory ganglionic neurons of cattle. The exclusive viral RNA expressed in a latent infection is the latency-related (LR) RNA, suggesting that it regulates some aspect of a latent infection. During the course of a productive infection, alphaherpesviruses induce certain events which occur during cell cycle progression. Consequently, we hypothesized that a BHV-1 infection might induce events in neurons which occur during cell cycle progression. In agreement with this hypothesis, cyclin A was detected in neurons of trigeminal ganglia when rabbits were infected. Neuronal cell cycle progression or inappropriate expression of …
Bovine Cell Line Resistant To In Vtro Infection By Bovine Viral Darrheavirus And All Other Known Pestiviruses, Ruben O. Donis, Eduardo F. Flores
Bovine Cell Line Resistant To In Vtro Infection By Bovine Viral Darrheavirus And All Other Known Pestiviruses, Ruben O. Donis, Eduardo F. Flores
School of Veterinary and Biomedical Sciences: Faculty Publications
Bovine cell line resistant to infection by the pestiviruses Bovine Viral Diarrhea Virus (BVDV), Hog Cholera Virus (HCV) and Border Disease Virus (BDV) and all progeny and mutants thereof. A bovine cell line (CRIB) that is resistant to infection by cytopathic and non-cytopathic BVDV and by other Pestiviruses due to a stable, recessive genetic defect which blocks infection at the level of viral entry.