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Protein Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girk) In Breast Cancer Cells, Madhu S. Dhar, Howard K. Plummer
Protein Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girk) In Breast Cancer Cells, Madhu S. Dhar, Howard K. Plummer
Faculty Publications and Other Works -- Large Animal Clinical Sciences
Background
Previous data from our laboratory has indicated that a functional link exists between the G-protein-coupled inwardly rectifying potassium (GIRK) channel and the beta-adrenergic receptor pathway in breast cancer cell lines, and these pathways were involved in growth regulation of these cells. Alcohol is an established risk factor for breast cancer and has been found to open GIRK. In order to further investigate GIRK channels in breast cancer and possible alteration by ethanol, we identified GIRK channel protein expression in breast cancer cells.
Results
Cell pellets were collected and membrane protein was isolated to determine GIRK protein expression. GIRK protein …