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Full-Text Articles in Medicine and Health Sciences
Edema Disease-Like Brain Lesions In Gnotobiotic Piglets Infected With Escherichia Coli Serotype 0157:H7, David H. Francis, Rodney A. Moxley, Cecile Y. Andraos
Edema Disease-Like Brain Lesions In Gnotobiotic Piglets Infected With Escherichia Coli Serotype 0157:H7, David H. Francis, Rodney A. Moxley, Cecile Y. Andraos
School of Veterinary and Biomedical Sciences: Faculty Publications
Gnotobiotic piglets inoculated with Escherichia coli serotype 0157:H7 strains that produced Shiga-like toxin II developed brain lesions similar to those observed in edema disease of swine, including arteriolar necrosis and malacia. Loss of ability to produce Shiga-like toxin II resulted in loss of ability to cause brain lesions.
Impairment Of Melibiose Utilization In Streptococcus Mutans Serotype C Gtfa Mutants, Raul G. Barletta, Roy Curtiss Iii
Impairment Of Melibiose Utilization In Streptococcus Mutans Serotype C Gtfa Mutants, Raul G. Barletta, Roy Curtiss Iii
School of Veterinary and Biomedical Sciences: Faculty Publications
The Streptococcus mutans serotype c gtfA gene encodes a 55-kilodalton sucrose-hydrolyzing enzyme. Analysis of S. mutans gtfA mutants revealed that the mutant strains were specifically impaired in the ability to use melibiose as a sole carbon source. S. mutans gafA mutant strains synthesized less α-galactosidase activity inducible by raffinose than wild-type strains. Melibiose (an inducer in wild-type strains) failed to induce significant levels of a-galactosidase in the mutant strains. We hypothesize that melibiose use by . mutans requires the interaction of the GtfA enzyme, or another gene product under the control of the gtfA promoter, with other gene product(s) involved …