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Articles 1 - 30 of 31
Full-Text Articles in Medicine and Health Sciences
The Herpes Simplex Virus Type 1 Locus That Encodes The Latency-Associated Transcript Enhances The Frequency Of Encephalitis In Male Balb/C Mice, Clinton J. Jones, Melissa Inman, Weiping Peng, Gail A. Henderson, Alan R. Doster, Guey-Chuen Perng, Anisa Kaenjak Angeletti
The Herpes Simplex Virus Type 1 Locus That Encodes The Latency-Associated Transcript Enhances The Frequency Of Encephalitis In Male Balb/C Mice, Clinton J. Jones, Melissa Inman, Weiping Peng, Gail A. Henderson, Alan R. Doster, Guey-Chuen Perng, Anisa Kaenjak Angeletti
School of Veterinary and Biomedical Sciences: Faculty Publications
Herpes simplex virus type 1 (HSV-1) is the leading cause of virus-induced encephalitis; however, the viral genes that regulate encephalitis have not been well characterized. In this study, we tested whether the LAT (latency-associated transcript) locus regulates the frequency of encephalitis in male or female mice. Male BALB/c mice are more susceptible to HSV-1-induced encephalitis than age-matched female BALB/c mice. Deletion of LAT coding sequences reduced the frequency of encephalitis. A recombinant virus containing the first 1.5 kb of the LAT coding sequence induces levels of encephalitis in male BALB/c mice similar to those induced by wild-type HSV-1.
A Herpes Simplex Virus Type 1 Mutant Expressing A Baculovirus Inhibitor Of Apoptosis Gene In Place Of Latency-Associated Transcript Has A Wild-Type Reactivation Phenotype In The Mouse, Ling Jin, Guey-Chuen Perng, Kevin R. Mott, Nelson Osorio, Julie Naito, David J. Brick, Dale Carpenter, Clinton J. Jones, Steven L. Wechsler
A Herpes Simplex Virus Type 1 Mutant Expressing A Baculovirus Inhibitor Of Apoptosis Gene In Place Of Latency-Associated Transcript Has A Wild-Type Reactivation Phenotype In The Mouse, Ling Jin, Guey-Chuen Perng, Kevin R. Mott, Nelson Osorio, Julie Naito, David J. Brick, Dale Carpenter, Clinton J. Jones, Steven L. Wechsler
School of Veterinary and Biomedical Sciences: Faculty Publications
The latency-associated transcript (LAT) is essential for the wild-type herpes simplex virus type 1 (HSV-1) high-reactivation phenotype since LAT- mutants have a low-reactivation phenotype. We previously reported that LAT can decrease apoptosis and proposed that this activity is involved in LAT’s ability to enhance the HSV-1 reactivation phenotype. The first 20% of the primary 8.3-kb LAT transcript is sufficient for enhancing the reactivation phenotype and for decreasing apoptosis, supporting this proposal. For this study, we constructed an HSV-1 LAT- mutant that expresses the baculovirus antiapoptosis gene product cpIAP under control of the LAT promoter and in place of …
Enhanced Pathogenicity Of Candida Albicans Pre-Treated With Subinhibitory Concentrations Of Fluconazole In A Mouse Model Of Disseminated Candidiasis, Dhammika H.M.L.P. Navarathna, Jacob M. Hornby, Natasha Hoerrmann, Anne M. Parkhurst, Gerald E. Duhamel, Kenneth Nickerson
Enhanced Pathogenicity Of Candida Albicans Pre-Treated With Subinhibitory Concentrations Of Fluconazole In A Mouse Model Of Disseminated Candidiasis, Dhammika H.M.L.P. Navarathna, Jacob M. Hornby, Natasha Hoerrmann, Anne M. Parkhurst, Gerald E. Duhamel, Kenneth Nickerson
School of Veterinary and Biomedical Sciences: Faculty Publications
Objectives: To investigate the relative pathogenicity of Candida albicans treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis. Previous studies indicate that these cells secrete 10 times more farnesol than do untreated cells. In our usage, subinhibitory means a concentration which causes a prominent decrease in turbidity but still allows some cell growth. Methods: C. albicans A72 cells were grown overnight in 0–5.0 mM fluconazole, washed, and inoculated in mice by tail vein injection. Groups of 15 or 16 mice were injected with 1.3 • 106cells and mortality was recorded for 7 days post-inoculation. …
Examining The Risk Of Disease Transmission Between Wild Dall’S Sheep And Mountain Goats, And Introduced Domestic Sheep, Goats, And Llamas In The Northwest Territories, Elena Garde, Susan Kutz, Helen Schwantje, Alasdair Veitch, Emily Jenkins, Brett Elkin
Examining The Risk Of Disease Transmission Between Wild Dall’S Sheep And Mountain Goats, And Introduced Domestic Sheep, Goats, And Llamas In The Northwest Territories, Elena Garde, Susan Kutz, Helen Schwantje, Alasdair Veitch, Emily Jenkins, Brett Elkin
Other Publications in Zoonotics and Wildlife Disease
This risk assessment has been carried out following the guidelines for Health Risk Analysis entitled “Wild Animal Translocations” prepared by the Canadian Cooperative Wildlife Health Centre (http://wildlife1.usask.ca). It includes 9 comprehensive appendices of bacterial, viral, parasitic and fungal organisms reported from domestic sheep, goats, llamas and wild sheep and mountain goats. The report is a breakdown of those appendices into discussions of organisms of major concern, organisms of unknown concern, organisms of minimal concern, and those that cause no apparent disease, are not transmissible between the species of interest, or do not occur in Canada. Where possible, organisms were assigned …
United States Patent: D-Alanine Racemase Mutants Of Mycobacteria And Uses Therefore, Raul G. Barletta, Ofelia Barletta-Chacon
United States Patent: D-Alanine Racemase Mutants Of Mycobacteria And Uses Therefore, Raul G. Barletta, Ofelia Barletta-Chacon
School of Veterinary and Biomedical Sciences: Faculty Publications
The present invention is directed to D-alanine racemase mutants of mycobacterial species. The D-alanine racemase gene (alrA) is involved in the systhesis of D-alanine, a basic component of peptidoglycan that forms the backbone of the bacterial cell wall. The present invention is also directed to methods of making live-attenuated vaccines against pathogenic mycobacteria using such alrA mutants and to the vaccines made according to such methods. The present invention is further directed to use of alrA mutants in methods for screening antimycobacterial agents that are synergistic with peptidoglycan inhibitors. Finally, the present invention is directed to methods to identify new …
Antibody Responses In Reindeer (Rangifer Tarandus) Infected With Mycobacterium Bovis, W. R. Waters, M. V. Palmer, J. P. Bannantine, R. Greenwald, J. Esfandiari, P. Andersen, J. Mcnair, J. M. Pollock, K. P. Lyashchenko
Antibody Responses In Reindeer (Rangifer Tarandus) Infected With Mycobacterium Bovis, W. R. Waters, M. V. Palmer, J. P. Bannantine, R. Greenwald, J. Esfandiari, P. Andersen, J. Mcnair, J. M. Pollock, K. P. Lyashchenko
Michigan Bovine Tuberculosis Bibliography and Database
Despite having a very low incidence of disease, reindeer (Rangifer tarandus) are subject to tuberculosis (TB) testing requirements for interstate shipment and herd accreditation in the United States. Improved TB tests are desperately needed, as many reindeer are falsely classified as reactors by current testing procedures. Sera collected sequentially from 11 (experimentally) Mycobacterium bovis-infected reindeer and 4 noninfected reindeer were evaluated by enzyme-linked immunosorbent assay (ELISA), immunoblotting, and multiantigen print immunoassay (MAPIA) for antibody specific to M. bovis antigens. Specific antibody was detected as early as 4 weeks after challenge with M. bovis. By MAPIA, sera …
Weast Nile Virus Serosurveillance In Iowa White-Tailed Deer (1999-2003), Julian Santatella, Robert Mclean, Jeffrey S. Hall, James S. Gill, Richard A. Bowen, Harlo H. Hadow, Larry Clark
Weast Nile Virus Serosurveillance In Iowa White-Tailed Deer (1999-2003), Julian Santatella, Robert Mclean, Jeffrey S. Hall, James S. Gill, Richard A. Bowen, Harlo H. Hadow, Larry Clark
USDA Wildlife Services: Staff Publications
Sera from white-tailed deer (Odocoileus virginianus) were collected in Iowa during the winter months (1999-2003), 2 years before and after West Nile virus (WNV) was first reported in Iowa (2001), and were analyzed for antibodies to WNV. Samples from 1999 to 2001 were antibody negalive by blocking enzyme-linikedI immunosorbent assay (bELISA) and plaque reduction neutralization test (PRNT90). Prevalence derived from bELISA (2002, 12.7%; 2003. 11.2%) and WNV PRNT90 (2002,7.9%; 2003, 8.5%) assays were similar. All sanlples were negative for antibodies against St. Louis encephalitis virus as determined by PRNT90. Antibodies to flaviviruses were …
The Locus Encompassing The Latency-Associated Transcript Of Herpes Simplex Virus Type 1 Interferes With And Delays Interferon Expression In Productively Infected Neuroblastoma Cells And Trigeminal Ganglia Of Acutely Infected Mice, Weiping Peng, Gail A. Henderson, Melissa Inman, Lbachir Benmohamed, Guey-Chuen Perng, Steven L. Wechsler, Clinton J. Jones
The Locus Encompassing The Latency-Associated Transcript Of Herpes Simplex Virus Type 1 Interferes With And Delays Interferon Expression In Productively Infected Neuroblastoma Cells And Trigeminal Ganglia Of Acutely Infected Mice, Weiping Peng, Gail A. Henderson, Melissa Inman, Lbachir Benmohamed, Guey-Chuen Perng, Steven L. Wechsler, Clinton J. Jones
School of Veterinary and Biomedical Sciences: Faculty Publications
The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is the only abundant viral transcript expressed in latently infected neurons. LAT inhibits apoptosis, suggesting that it regulates latency by promoting the survival of infected neurons. The LAT locus also contains a newly described gene (AL), which is antisense to LAT and partially overlaps LAT encoding sequences. When human (SK-N-SH) or mouse (neuro-2A) neuroblastoma cells were infected with a virus that does not express LAT or AL gene products (dLAT2903), beta interferon (IFN- β) and IFN- α RNA expression was detected earlier relative to the same cells infected with HSV-1 …
Tularemia: Emergence/Re-Emergence, Jeannine M. Petersen, Martin E. Schriefer
Tularemia: Emergence/Re-Emergence, Jeannine M. Petersen, Martin E. Schriefer
Other Publications in Zoonotics and Wildlife Disease
Francisella tularensis is a gram-negative coccobacillus and the etiologic agent of the zoonotic disease tularemia. First described in 1911 in Tulare County, California, it has since been reported throughout the Northern Hemisphere, with natural infections reported among an unusually wide range of vertebrates and invertebrates. In recent years, tularemia has emerged in new geographic locations, populations, and settings. This review will serve to highlight mechanisms contributing to the recent emergence of tularemia as well as a repertoire of diagnostic tools useful for detecting and diagnosing disease.
5-Ht1b Receptor-Mediated Presynaptic Inhibition Of Gaba Release In The Suprachiasmatic Nucleus, Jayne R. Bramley, Patricia J. Sollars, Gary E. Pickard, F. Edward Dudek
5-Ht1b Receptor-Mediated Presynaptic Inhibition Of Gaba Release In The Suprachiasmatic Nucleus, Jayne R. Bramley, Patricia J. Sollars, Gary E. Pickard, F. Edward Dudek
School of Veterinary and Biomedical Sciences: Faculty Publications
The suprachiasmatic nucleus (SCN) receives a dense serotonergic innervation that modulates photic input to the SCN via serotonin 1B (5-HT1B) presynaptic receptors on retinal glutamatergic terminals. However, the majority of 5-HT1B binding sites in the SCN are located on nonretinal terminals and most axonal terminals in the SCN are GABAergic. We therefore tested the hypothesis that 5-HT1B receptors might also be located on SCN GABAergic terminals by examining the effects of the highly selective 5-HT1B receptor agonist CP-93,129 on SCN miniature inhibitory postsynaptic currents (mIPSCs). Whole cell patch-clamp recordings of mIPSCs were obtained from rat …
Chronic Wasting Disease (Cwd) Data Clearinghouse
Chronic Wasting Disease (Cwd) Data Clearinghouse
Other Publications in Zoonotics and Wildlife Disease
The National Biological Information Infrastructure (NBII) is an electronic information network that provides access to biological data and information on our nation’s plants, animals, and ecosystems. Information contributed by federal, state, and local government agencies; non-government organizations; and private-sector organizations is linked through the NBII gateway and made accessible to a variety of audiences, including researchers, natural resource managers, decision-makers, educators, students, and other members of the general public. Implementation of the NBII is being accomplished through the development of "nodes" that serve as entry points to the network. These nodes function as fully digital, distributed, and interactive systems that …
Department Of Veterinary And Biomedical Sciences: 2005 Annual Report
Department Of Veterinary And Biomedical Sciences: 2005 Annual Report
Veterinary and Biomedical Sciences -- Department Information and History
Veterinary and Biomedical Sciences Personnel
VBMS Teaching Program - Courses 2005
VBMS Grants and Contracts Program, 2005
Publications by VBMS Faculty in 2005
Selected Committees, Editorial and Other Appointments. 2005
Articles Regarding the Department in 2005
Departmental Budget Summaries, 2005
Nebraska Agricultural Statistics, 2004/2005.
Cutting Edge: Cd4+Cd25+ Regulatory T Cells Contribute To Gender Differences In Susceptibility To Experimental Autoimmune Encephalomyelitis, Jay Reddy, Hanspeter Waldner, Xingmin Zhang, Zsolt Illes, Kai W. Wucherpfennig, Raymond A. Sobel, Vijay K. Kuchroo
Cutting Edge: Cd4+Cd25+ Regulatory T Cells Contribute To Gender Differences In Susceptibility To Experimental Autoimmune Encephalomyelitis, Jay Reddy, Hanspeter Waldner, Xingmin Zhang, Zsolt Illes, Kai W. Wucherpfennig, Raymond A. Sobel, Vijay K. Kuchroo
Jay Reddy Publications
Female B10.S mice are highly resistant to proteolipid protein (PLP) 139–151-induced experimental autoimmune encephalomyelitis (EAE) and depletion of PLP 139–151- reactive CD4+CD25+regulatory T (Treg) cells can slightly increase their EAE susceptibility. Although male B10.S mice are moderately susceptible to EAE, we report that depletion of Treg cells in male B10.S mice before immunization with PLP 139–151 renders them highly susceptible to severe EAE with more CNS neutrophil infiltrates than nondepleted controls. Increased susceptibility is associated with an enhanced PLP 139–151-specific T cell response and greater production of IFN-γ, IL-6, and IL-17. Male CD4+CD25+ effector cells depleted of Treg cells proliferate …
Chronic Wasting Disease Of Elk: Transmissibility To Humans Examined By Transgenic Mouse Models, Qingzhong Kong, Shenghai Huang, Wenquan Zou, Difernando Vanegas, Meiling Wang, Di Wu, Jue Yuan, Mengjie Zheng, Hua Bai, Huayun Deng, Ken Chen, Allen L. Jenny, Katherine I. O'Rourke, Ermais D. Belay, Lawrence B. Schonberger, Robert B. Pertersen, Man-Sun Sy, Shu G. Chen, Pierluigi Gambetti
Chronic Wasting Disease Of Elk: Transmissibility To Humans Examined By Transgenic Mouse Models, Qingzhong Kong, Shenghai Huang, Wenquan Zou, Difernando Vanegas, Meiling Wang, Di Wu, Jue Yuan, Mengjie Zheng, Hua Bai, Huayun Deng, Ken Chen, Allen L. Jenny, Katherine I. O'Rourke, Ermais D. Belay, Lawrence B. Schonberger, Robert B. Pertersen, Man-Sun Sy, Shu G. Chen, Pierluigi Gambetti
Other Publications in Zoonotics and Wildlife Disease
Chronic wasting disease (CWD), a prion disease affecting free-ranging and captive cervids (deer and elk), is widespread in the United States and parts of Canada. The large cervid population, the popularity of venison consumption, and the apparent spread of the CWD epidemic are likely resulting in increased human exposure to CWD in the United States. Whether CWDis transmissible to humans, as has been shown for bovine spongiform encephalopathy (the prion disease of cattle), is unknown. We generated transgenic mice expressing the elk or human prion protein (PrP) in a PrP-null background. After intracerebral inoculation with elk CWD prion, two lines …
Role Of The Hypervariable Hinge Region Of Phosphoprotein P Of Vesicular Stomatitis Virus In Viral Rna Synthesis And Assembly Of Infectious Virus Particles, Subash C. Das, Asit K. Pattnaik
Role Of The Hypervariable Hinge Region Of Phosphoprotein P Of Vesicular Stomatitis Virus In Viral Rna Synthesis And Assembly Of Infectious Virus Particles, Subash C. Das, Asit K. Pattnaik
School of Veterinary and Biomedical Sciences: Faculty Publications
The phosphoprotein (P protein) of vesicular stomatitis virus (VSV) is an essential subunit of the viral RNAdependent RNA polymerase and has multiple functions residing in its different domains. In the present study, we examined the role of the hypervariable hinge region of P protein in viral RNA synthesis and recovery of infectious VSV by using transposon-mediated insertion mutagenesis and deletion mutagenesis. We observed that insertions of 19-amino-acid linker sequences at various positions within this region affected replication and transcription functions of the P protein to various degrees. Interestingly, one insertion mutant was completely defective in both transcription and replication. Using …
Factors Associated With The Presence Of Coliforms In The Feed And Water Of Feedlot Cattle, Michael W. Sanderson, Jan M. Sargeant, David G. Renter, Dicky Dee Griffin, Robert A. Smith
Factors Associated With The Presence Of Coliforms In The Feed And Water Of Feedlot Cattle, Michael W. Sanderson, Jan M. Sargeant, David G. Renter, Dicky Dee Griffin, Robert A. Smith
School of Veterinary and Biomedical Sciences: Faculty Publications
The objective of this study was to investigate coliform counts in feedlot cattle water and feed rations and their associations with management, climate, fecal material, and water Escherichia coli O157 using a cross-sectional study design. Coliform counts were performed on feed samples from 671 pens on 70 feedlots and on water samples from 702 pens on 72 feedlots in four U.S. states collected between May and August 2001. Management and climate factors were obtained by survey and observation. Month of sampling (higher in May and June), presence of corn silage in the ration (negative association), temperature of the feed 1 …
Serologic Survey Of Select Infectious Diseases In Coyotes And Raccoons In Nebraska, Richard Bischof, Douglas G. Rogers
Serologic Survey Of Select Infectious Diseases In Coyotes And Raccoons In Nebraska, Richard Bischof, Douglas G. Rogers
School of Veterinary and Biomedical Sciences: Faculty Publications
To obtain data about select zoonotic and other infectious diseases in free-ranging predators in five ecoregions in Nebraska, sera were collected from 67 coyotes (Canis latrans) and 63 raccoons (Procyon lotor)) from November 2002 through January 2003. For coyotes, antibodies were detected against canine distemper virus (CDV, 61%), Francisella tularensis) (32%), Rickettsia rickettsi) (13%), and flaviviruses (48%). None of the coyote sera had antibodies to Borrelia burgdorferi, Brucella canis), or six serovars of Leptospira interrogans). Because serologic cross-reactivity exists among flaviviruses, 14 sera from flavivirus-positive coyotes were also tested for St. Louis …
Molecular Characterization Of Mycobacterium Tuberculosis Complex Isolates From Wild Ungulates In South-Central Spain, Christian Gortazar, Joaquín Vicente, Sofia Samper, Joseba M. Garrido, Isabel Fernandez-De-Mera, Patricia Gavín, Ramón A. Juste, Carlos Martín, Pelayo Acevedo, Manuel De La Puentea, Ursula Höflea
Molecular Characterization Of Mycobacterium Tuberculosis Complex Isolates From Wild Ungulates In South-Central Spain, Christian Gortazar, Joaquín Vicente, Sofia Samper, Joseba M. Garrido, Isabel Fernandez-De-Mera, Patricia Gavín, Ramón A. Juste, Carlos Martín, Pelayo Acevedo, Manuel De La Puentea, Ursula Höflea
Michigan Bovine Tuberculosis Bibliography and Database
The role of European wild ungulates in the epidemiology of tuberculosis (TB) is still under discussion. This study describes the geographical distribution and molecular typing of 77 Mycobacterium tuberculosis complex isolates belonging either to M. bovis or to M. caprae, cultivated from hunter harvested red deer (Cervus elaphus) and European wild boar (Sus scrofa) in 24 Spanish localities, and compares them with spoligotypes detected previously in humans, livestock or wild animals, as described in the literature. The distribution of the molecular type patterns suggests that the population of M. tuberculosis complex strains isolated from Spanish …
Use Of An Electronic Nose To Diagnose Mycobacterium Bovis Infection In Badgers And Cattle, R. Fend, R. Geddes, S. Lesellier, H.-M. Vordermeier, L. A. L. Corner, E. Gormley, E. Costello, R. G. Hewinson, D. J. Marlin, A. C. Woodman, M. A. Chambers
Use Of An Electronic Nose To Diagnose Mycobacterium Bovis Infection In Badgers And Cattle, R. Fend, R. Geddes, S. Lesellier, H.-M. Vordermeier, L. A. L. Corner, E. Gormley, E. Costello, R. G. Hewinson, D. J. Marlin, A. C. Woodman, M. A. Chambers
Michigan Bovine Tuberculosis Bibliography and Database
It is estimated that more than 50 million cattle are infected with Mycobacterium bovis worldwide, resulting in severe economic losses. Current diagnosis of tuberculosis (TB) in cattle relies on tuberculin skin testing, and when combined with the slaughter of test-positive animals, it has significantly reduced the incidence of bovine TB. The failure to eradicate bovine TB in Great Britain has been attributed in part to a reservoir of the infection in badgers (Meles meles). Accurate and reliable diagnosis of infection is the cornerstone of TB control. Bacteriological diagnosis has these characteristics, but only with samples collected postmortem. Unlike …
Hidden Effects Of Chronic Tuberculosis In African Buffalo, Anna E. Jolles, David V. Cooper, Simon A. Levin
Hidden Effects Of Chronic Tuberculosis In African Buffalo, Anna E. Jolles, David V. Cooper, Simon A. Levin
Michigan Bovine Tuberculosis Bibliography and Database
Infectious diseases can bring about population declines and local host extinctions, contributing significantly to the global biodiversity crisis. Nonetheless, studies measuring population-level effects of pathogens in wild host populations are rare, and taxonomically biased toward avian hosts and macroparasitic infections. We investigated the effects of bovine tuberculosis (bTB), caused by the bacterial pathogen Mycobacterium bovis, on African buffalo (Syncerus caffer) at Hluhluwe-iMfolozi Park, South Africa. We tested 1180 buffalo for bTB infection between May 2000 and November 2001. Most infections were mild, confirming the chronic nature of the disease in buffalo. However, our data indicate that bTB …
Spatial Management Of Wildlife Disease, Richard Horan, Christopher Wolf, Eli P. Fenichel, Kenneth H. Mathews, Jr.
Spatial Management Of Wildlife Disease, Richard Horan, Christopher Wolf, Eli P. Fenichel, Kenneth H. Mathews, Jr.
Michigan Bovine Tuberculosis Bibliography and Database
The spread of wildlife diseases is a major threat to livestock, human health, resource-based recreation, and biodiversity conservation (Cleaveland, Laurenson, and Taylor). The development of economically sound wildlife disease-management strategies requires an understanding of the links between ecological functions (e.g., disease transmission and wildlife dispersal) and economic choices, and the associated tradeoffs. Spatial linkages are particularly relevant. Yet while ecologists have long-argued that space is important (Hudson et al.), prior economic work has largely ignored spatial issues.
For instance, Horan and Wolf analyzed a case study of bovine tuberculosis (bTB) in Michigan deer, a problem where the disease appears to …
Michigan Bovine Tuberculosis Eradication Project: 2005 Activities Report And Conference Proceedings
Michigan Bovine Tuberculosis Eradication Project: 2005 Activities Report And Conference Proceedings
Michigan Bovine Tuberculosis Bibliography and Database
On June 7 and 8, 2005, the State of Michigan and U.S. Department of Agriculture hosted the ninth annual bovine Tuberculosis (TB) meeting of scientists, with the intent to share research information and provide updates on policies, regulations and activities regarding bovine TB.
This document is a thank you to stakeholders and serves as an annual report offering insight into the finer points of this multi-agency project. The year 2005 has been one of milestones. The Upper Peninsula received TB-Free Status; only one TB positive farm was found during routine surveillance testing; and the disease prevalence rate in Deer Management …
Mycobacterium Avium Subsp. Paratuberculosis From Free-Ranging Deer And Rabbits Surrounding Minnesota Dairy Herds, Eran A. Raizman, Scott J. Wells, Peter A. Jordan, Glenn D. Delgiudice, Russell R. Bey
Mycobacterium Avium Subsp. Paratuberculosis From Free-Ranging Deer And Rabbits Surrounding Minnesota Dairy Herds, Eran A. Raizman, Scott J. Wells, Peter A. Jordan, Glenn D. Delgiudice, Russell R. Bey
Michigan Bovine Tuberculosis Bibliography and Database
The objectives of this study were to estimate the prevalence of Mycobacterium avium subsp. paratuberculosis (MAP) among deer and rabbits surrounding infected and noninfected Minnesota dairy farms using fecal culture, and to describe the frequency that farm management practices were used that could potentially lead to transmission of infection between these species. Fecal samples from cows and the cow environment were collected from 108 Minnesota dairy herds, and fecal pellets from free-ranging white-tailed deer and eastern cottontail rabbits were collected from locations surrounding 114 farms; all samples were tested using bacterial culture. In addition, a questionnaire was administered to 114 …
Bovine Tuberculosis Eradication: Uniform Methods And Rules, Effective January 1, 2005
Bovine Tuberculosis Eradication: Uniform Methods And Rules, Effective January 1, 2005
Michigan Bovine Tuberculosis Bibliography and Database
These Uniform Methods and Rules (UM&R) are the minimum standards adopted and approved by the Deputy Administrator, Veterinary Services (VS), Animal and Plant Health Inspection Service (APHIS), on January 20, 2005. They were established for the maintenance of tuberculosis-free accredited herds of cattle and bison and the maintenance of State or zone status in the U.S. Department of Agriculture’s (USDA) tuberculosis eradication program.
These minimum standards do not preclude the adoption of more stringent standards by any State or zone.
Latency-Related Gene Encoded By Bovine Herpesvirus 1 Promotes Virus Growth And Reactivation From Latency In Tonsils Of Infected Calves, Sandra Perez, Melissa Inman, Alan R. Doster, Clinton J. Jones
Latency-Related Gene Encoded By Bovine Herpesvirus 1 Promotes Virus Growth And Reactivation From Latency In Tonsils Of Infected Calves, Sandra Perez, Melissa Inman, Alan R. Doster, Clinton J. Jones
School of Veterinary and Biomedical Sciences: Faculty Publications
Infection of calves with bovine herpesvirus 1 (BHV-1) results in transient immunosuppression that may lead to bacterium-induced pneumonia and, occasionally, death. Although sensory neurons in the trigeminal ganglia (TG) are the primary site of BHV-1 latency, viral genomes are detected in the tonsils of latently infected calves. Dexamethasone (DEX) consistently induces reactivation from latency, and viral gene expression is detected in TG and tonsils. In sensory neurons of latently infected calves, the latency-related (LR) gene is abundantly expressed and is required for reactivation from latency. In the present study, we compared the abilities of wild-type (wt) BHV-1 and a strain …
Predictive Spatial Dynamics And Strategic Planning For Raccoon Rabies Emergence In Ohio, James E. Childs, David L. Smith, Colin A. Russell, Leslie A. Real
Predictive Spatial Dynamics And Strategic Planning For Raccoon Rabies Emergence In Ohio, James E. Childs, David L. Smith, Colin A. Russell, Leslie A. Real
Other Publications in Zoonotics and Wildlife Disease
Rabies is an important public health concern in North America because of recent epidemics of a rabies virus variant associated with raccoons. The costs associated with surveillance, diagnostic testing, and post-exposure treatment of humans exposed to rabies have fostered coordinated efforts to control rabies spread by distributing an oral rabies vaccine to wild raccoons. Authorities have tried to contain westward expansion of the epidemic front of raccoonassociated rabies via a vaccine corridor established in counties of eastern Ohio, western Pennsylvania, and West Virginia. Although sporadic cases of rabies have been identified in Ohio since oral rabies vaccine distribution in 1998, …
Evaluation Of Western Blotting Methods Using Samples With Or Without Sodium Phosphotungstic Acid Precipitation For Diagnosis Of Scrapie And Chronic Wasting Disease, Hongsheng Huang, Jasmine Rendulich, Dan Stevenson, Katherine I. O'Rourke, Aru Balachandran
Evaluation Of Western Blotting Methods Using Samples With Or Without Sodium Phosphotungstic Acid Precipitation For Diagnosis Of Scrapie And Chronic Wasting Disease, Hongsheng Huang, Jasmine Rendulich, Dan Stevenson, Katherine I. O'Rourke, Aru Balachandran
Other Publications in Zoonotics and Wildlife Disease
The purpose of this study was to enhance the sensitivity of the Western blot (WB) test for use as an alternative and confirmatory method for the diagnosis of scrapie and chronic wasting disease (CWD) in Canada by comparing 2 sample preparation procedures: an abnormal prion protein (PrPSc) concentration procedure using sodium phosphotungstic acid (PTA) precipitation and a procedure using crude sample without precipitation. A total of 100 cerebrum samples (52 sheep and 48 elk), including 66 negative (31 sheep, 35 elk) and 34 positive (21 scrapie and 13 CWD positive) samples diagnosed by using immunohistochemistry (IHC) on retropharyngeal …
The Incidence Of Genotypes At Codon 171 Of The Prion Protein Gene (Prnp) In Five Breeds Of Sheep And Production Traits Of Ewes Associated With Those Genotypes, B. M. Alexander, R. H. Stobart, W. C. Russell, Katherine I. O'Rourke, G. S. Lewis, J. R. Logan, J. V. Duncan, G. E. Moss
The Incidence Of Genotypes At Codon 171 Of The Prion Protein Gene (Prnp) In Five Breeds Of Sheep And Production Traits Of Ewes Associated With Those Genotypes, B. M. Alexander, R. H. Stobart, W. C. Russell, Katherine I. O'Rourke, G. S. Lewis, J. R. Logan, J. V. Duncan, G. E. Moss
Other Publications in Zoonotics and Wildlife Disease
Scrapie is one of several transmissible spongiform encephalopathies of livestock. Disease susceptibility is linked to polymorphisms in the normal prion protein gene that encodes the mammalian prion precursor. Codon 171 of this gene is a major determinant of scrapie susceptibility. Selection for arginine (R) at codon 171 is encouraged by the USDA to decrease the incidence of scrapie. Objectives of this study were to determine the frequency of R allele variants at codon 171 in a sample of sheep from five breeds (Columbia, Hampshire, Rambouillet, Suffolk, and Targhee) and western white-faced commercial ewes and to determine whether the R allele …
Experimental Transmission Of Chronic Wasting Disease Agent From Mule Deer To Cattle By The Intracerebral Route, Amir N. Hamir, Robert A. Kunkle, Randall C. Cutlip, Janice M. Miller, Katherine I. O'Rourke, Elizabeth S. Williams, Michael W. Miller, Mick J. Stack, Melanie J. Chaplin, Jügen A. Richt
Experimental Transmission Of Chronic Wasting Disease Agent From Mule Deer To Cattle By The Intracerebral Route, Amir N. Hamir, Robert A. Kunkle, Randall C. Cutlip, Janice M. Miller, Katherine I. O'Rourke, Elizabeth S. Williams, Michael W. Miller, Mick J. Stack, Melanie J. Chaplin, Jügen A. Richt
Other Publications in Zoonotics and Wildlife Disease
This communication reports final observations on experimental transmission of chronic wasting disease (CWD) from mule deer to cattle by the intracerebral route. Thirteen calves were inoculated intracerebrally with brain suspension from mule deer naturally affected with CWD. Three other calves were kept as uninoculated controls. The experiment was terminated 6 years after inoculation. During that time, abnormal prion protein (PrPres) was demonstrated in the central nervous system (CNS) of 5 cattle by both immunohistochemistry and Western blot. However, microscopic lesions suggestive of spongiform encephalopathy (SE) in the brains of these PrPres-positive animals were subtle in 3 …
Wildlife-Cattle Interactions In Northern Michigan: Implications For The Transmission Of Bovine Tuberculosis, Jerry Alan Hill
Wildlife-Cattle Interactions In Northern Michigan: Implications For The Transmission Of Bovine Tuberculosis, Jerry Alan Hill
Michigan Bovine Tuberculosis Bibliography and Database
Bovine tuberculosis (Mycobacterium bovis) was discovered in northern Michigan white-tailed deer (Odocoileus virginianus) in 1994, and has been known to exist in Michigan cattle herds since 1998. Despite efforts to eradicate the disease in cattle, infection and re-infection of farms continues to occur, suggesting transmission among cattle, deer, or other wildlife reservoirs. The goals of this study were to document wildlife activity on farms and evaluate the possible role wildlife play in the ecology of bovine tuberculosis (TB) in Michigan. Visual observations were conducted on farms in a 5-county area of northern Michigan to document direct …