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Full-Text Articles in Medicine and Health Sciences
Lung And Nasal Lesions Caused By A Swine Chlamydial Isolate In Gnotobiotic Pigs, Douglas G. Rogers, Arthur A. Andersen, Breck D. Hunsaker
Lung And Nasal Lesions Caused By A Swine Chlamydial Isolate In Gnotobiotic Pigs, Douglas G. Rogers, Arthur A. Andersen, Breck D. Hunsaker
School of Veterinary and Biomedical Sciences: Faculty Publications
The objective of this study was to determine whether a chlamydial isolate recovered from nasal swabs from swine with pneumonia could cause pneumonia and rhinitis in gnotobiotic pigs. The identity of the isolate currently is unknown, but it shares characteristics with Chlamydia trachomatis. After propagation in Vero cells and preparation of the inoculum (2.5 x 1010 inclusion-forming units/ml), Chlamydiae were instilled into nostrils (1.0 ml/nostril) and lungs (2.0 ml intralaryngeally) of 15 anesthetized 3-day-old gnotobiotic piglets. Five age-matched gnotobiotic piglets were anesthetized and sham infected with uninfected cell culture lysates. Two treated piglets were moribund and 2 were severely …
Intestinal Lesions Caused By Two Swine Chlamydial Isolates In Gnotobiotic Pigs, Douglas G. Rogers, Arthur A. Andersen
Intestinal Lesions Caused By Two Swine Chlamydial Isolates In Gnotobiotic Pigs, Douglas G. Rogers, Arthur A. Andersen
School of Veterinary and Biomedical Sciences: Faculty Publications
The objective of this study was to determine whether 2 distinct chlamydial isolates recovered from the intestines and feces of diarrheic nursery pigs could cause intestinal lesions in gnotobiotic pigs. Both isolates share biological characteristics with Chlamydia trachomatis. Chlamydial isolates R27 and R19 were propagated in Vero cells or embryonated eggs, respectively, and suspended in sucrose-phosphate-glutamine buffer with 10% fetal bovine serum for inoculation. Sham inocula were prepared from uninfected cell culture lysates and from uninfected eggs. Each piglet was fed 1 ml of inoculum or sham inoculum at 3-4 days of age. Ten piglets were each fed 10 …
Current Issues In Rabies Prevention In The United States: Health Dilemmas, Public Coffers, Private Interests, Charles E. Rupprecht, Jean S. Smith, John Krebs, Michael Niezgoda, James E. Childs
Current Issues In Rabies Prevention In The United States: Health Dilemmas, Public Coffers, Private Interests, Charles E. Rupprecht, Jean S. Smith, John Krebs, Michael Niezgoda, James E. Childs
Other Publications in Zoonotics and Wildlife Disease
Over the last 100 years, rabies in the United States has changed dramati~ally. More than 90% of all animal rabies cases reported annually to the CDC now occur in wildlife, whereas before 1960 the majority were in domestic animals. The principal rabies hosts today are wild carnivores and bats infected with several viral variants. Annual human deaths have fallen from more than a hundred at the turn of the century to one to two per year despite major outbreaks of animal rabies in several geographic areas. Modem day prophylaxis has proven nearly 100% successful; most human fatalities now occur in …
The Latency-Related Gene Of Bovine Herpesvirus 1 Encodes A Product Which Inhibits Cell Cycle Progression, L. M. Schang, Ashfaque Hossain, Clinton J. Jones
The Latency-Related Gene Of Bovine Herpesvirus 1 Encodes A Product Which Inhibits Cell Cycle Progression, L. M. Schang, Ashfaque Hossain, Clinton J. Jones
School of Veterinary and Biomedical Sciences: Faculty Publications
Bovine herpesvirus 1 (BHV-1) establishes a latent infection in the sensory ganglionic neurons of cattle. The exclusive viral RNA expressed in a latent infection is the latency-related (LR) RNA, suggesting that it regulates some aspect of a latent infection. During the course of a productive infection, alphaherpesviruses induce certain events which occur during cell cycle progression. Consequently, we hypothesized that a BHV-1 infection might induce events in neurons which occur during cell cycle progression. In agreement with this hypothesis, cyclin A was detected in neurons of trigeminal ganglia when rabbits were infected. Neuronal cell cycle progression or inappropriate expression of …
Bovine Cell Line Resistant To In Vtro Infection By Bovine Viral Darrheavirus And All Other Known Pestiviruses, Ruben O. Donis, Eduardo F. Flores
Bovine Cell Line Resistant To In Vtro Infection By Bovine Viral Darrheavirus And All Other Known Pestiviruses, Ruben O. Donis, Eduardo F. Flores
School of Veterinary and Biomedical Sciences: Faculty Publications
Bovine cell line resistant to infection by the pestiviruses Bovine Viral Diarrhea Virus (BVDV), Hog Cholera Virus (HCV) and Border Disease Virus (BDV) and all progeny and mutants thereof. A bovine cell line (CRIB) that is resistant to infection by cytopathic and non-cytopathic BVDV and by other Pestiviruses due to a stable, recessive genetic defect which blocks infection at the level of viral entry.
Comparison Of Gross Pathology, Histopathology, And Mycobacterial Culture For The Diagnosis Of Tuberculosis In Elk (Cervus Elaphus), Elizabeth B. Rohonczy, Arumuga V. Balachandran, Thomas W. Dukes, Janet B. Payeur, Jack C. Rhyan, Dennis A. Saari, Terry L. Whiting, Susan H. Wilson, Jerald L. Jarnagin
Comparison Of Gross Pathology, Histopathology, And Mycobacterial Culture For The Diagnosis Of Tuberculosis In Elk (Cervus Elaphus), Elizabeth B. Rohonczy, Arumuga V. Balachandran, Thomas W. Dukes, Janet B. Payeur, Jack C. Rhyan, Dennis A. Saari, Terry L. Whiting, Susan H. Wilson, Jerald L. Jarnagin
Michigan Bovine Tuberculosis Bibliography and Database
Using the isolation of Mycobacterium bovis as the reference standard, this study evaluated the sensitivity, specificity and kappa statistic of gross pathology (abattoir postmortem inspection), histopathology, and parallel or series combinations of the two for the diagnosis of tuberculosis in 430 elk and red deer. Two histopathology interpretations were evaluated: histopathology I, where the presence of lesions compatible with tuberculosis was considered positive, and histopathology II, where lesions compatible with tuberculosis or a select group of additional possible diagnoses were considered positive. In the 73 animals from which M. bovis was isolated, gross lesions of tuberculosis were most often in …
Cytokines In Pigs Bred Selectively For High And Low Immune Response [Abstract Only], Jay Reddy, Bruce N. Wilkie, Bonnie A. Mallard, Soren Rosendal
Cytokines In Pigs Bred Selectively For High And Low Immune Response [Abstract Only], Jay Reddy, Bruce N. Wilkie, Bonnie A. Mallard, Soren Rosendal
Jay Reddy Publications
Yorkshire pigs have been bred for high (H) and low (L) immune response based on selection for multiple antibody (Ab) and cell mediated immune response traits. High responders have better production and larger litter size when compared with controls and low responders. The ability of high and low line pigs to resist M. hyorhinis infection has been tested. The high responders had more rapid and higher Ab response and the severity of the disease was less, as judged by clinical and postmortem signs. However, arthritis was found to be relatively more severe in high responders. We hypothesized that the immune …
Microevolutionary Patterns And Molecular Markers: The Genetics Of Geographic Variation In Ascaris Suum, Steven A. Nadler
Microevolutionary Patterns And Molecular Markers: The Genetics Of Geographic Variation In Ascaris Suum, Steven A. Nadler
Harold W. Manter Laboratory of Parasitology: Faculty and Staff Publications
Molecular markers have been used only rarely to characterize the population genetic structure of nematodes. Published studies have suggested that different taxa may show distinct genetic architectures. Isoenzyme and RAPD markers have been used to investigate geographic variation of Ascaris suum at the level of infrapopulations (nematodes within individual hosts), within localities, and among geographic regions. Independent estimates of genetic differentiation among population samples based on isoenzyme and RAPD data showed similar patterns and substantial correlation. Heterozygote deficiencies within infrapopulations and large values for inbreeding coefficients among infrapopulations suggested that the composition of these populations was not consistent with a …