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Multidrug Efflux Systems (Mes): A Mechanism Of Resistance To Multidrug In Bacteria, Rungtip Chuanchuen, Herbert P. Schweizer

The Thai Journal of Veterinary Medicine

Bacterial antibiotic resistance is a growing problem with a global dimension. While the mechanisms of resistance vary from agent to agent, most of them are agent specific, providing resistance to a single or a class of anitimicrobials. Multidrug efflux systems have currently emerged as a predominant cause of antimicrobial resistance across a broad spectrum of structurally - unrelated antimicrobials. Efflux-mediated resistance is promoted by the exclusion of agents from the systems, resulting in reduced intracellular concentration of drugs. MES occur in many Gram-positive and Gram-negative bacteria, including medically important pathogens, therefore they are of significant concern. Expression of the systems …