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Full-Text Articles in Medicine and Health Sciences
Comparison Of The Equine Reference Sequence With Its Sanger Source Data And New Illumina Reads, Jovan Rebolledo-Mendez, Matthew S. Hestand, Stephen J. Coleman, Zheng Zeng, Ludovic Orlando, James N. Macleod, Ted Kalbfleisch
Comparison Of The Equine Reference Sequence With Its Sanger Source Data And New Illumina Reads, Jovan Rebolledo-Mendez, Matthew S. Hestand, Stephen J. Coleman, Zheng Zeng, Ludovic Orlando, James N. Macleod, Ted Kalbfleisch
Maxwell H. Gluck Equine Research Center Faculty Publications
The reference assembly for the domestic horse, EquCab2, published in 2009, was built using approximately 30 million Sanger reads from a Thoroughbred mare named Twilight. Contiguity in the assembly was facilitated using nearly 315 thousand BAC end sequences from Twilight's half brother Bravo. Since then, it has served as the foundation for many genome-wide analyses that include not only the modern horse, but ancient horses and other equid species as well. As data mapped to this reference has accumulated, consistent variation between mapped datasets and the reference, in terms of regions with no read coverage, single nucleotide variants, and small …
Protective Efficacy Of Centralized And Polyvalent Envelope Immunogens In An Attenuated Equine Lentivirus Vaccine, Jodi K. Craigo, Corin Ezzelarab, Sheila J. Cook, Chong Liu, David Horohov, Charles J. Issel, Ronald C. Montelaro
Protective Efficacy Of Centralized And Polyvalent Envelope Immunogens In An Attenuated Equine Lentivirus Vaccine, Jodi K. Craigo, Corin Ezzelarab, Sheila J. Cook, Chong Liu, David Horohov, Charles J. Issel, Ronald C. Montelaro
Maxwell H. Gluck Equine Research Center Faculty Publications
Lentiviral Envelope (Env) antigenic variation and related immune evasion present major hurdles to effective vaccine development. Centralized Env immunogens that minimize the genetic distance between vaccine proteins and circulating viral isolates are an area of increasing study in HIV vaccinology. To date, the efficacy of centralized immunogens has not been evaluated in the context of an animal model that could provide both immunogenicity and protective efficacy data. We previously reported on a live-attenuated (attenuated) equine infectious anemia (EIAV) virus vaccine, which provides 100% protection from disease after virulent, homologous, virus challenge. Further, protective efficacy demonstrated a significant, inverse, linear relationship …
Radionuclide Exposure In Animals And The Public Health Implications, Roseline Yemisi Olobatoke, Manny Mathuthu
Radionuclide Exposure In Animals And The Public Health Implications, Roseline Yemisi Olobatoke, Manny Mathuthu
Turkish Journal of Veterinary & Animal Sciences
Living tissues are usually exposed to varying degrees of radiation from natural and manmade radioactive substances. Depending on the type of radiation emitted and rate and dose of absorption, all radioactive substances are potentially hazardous. Previous researches on the biological effects of radiation as well as preventive measures have focused on human subjects, being the most radiosensitive species. However, exposure of animals to ionizing irradiation may negatively influence their production performance, resulting in some level of economic loss. In addition, many food animals may represent a significant pathway for transfer of radionuclides to humans, thereby adding to the exposure burden. …