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Full-Text Articles in Medicine and Health Sciences
Serological Survey Of Leptospira Infection In Arabian Horses In Poland, Bernard Wasiński, Katarzyna Paschalis-Trela, Jan Trela, Michał Czopowicz, Jerzy Kita, Monika Żychska, Anna Cywińska, Iwona Markowska-Daniel, Craig N. Carter, Lucjan Witkowski
Serological Survey Of Leptospira Infection In Arabian Horses In Poland, Bernard Wasiński, Katarzyna Paschalis-Trela, Jan Trela, Michał Czopowicz, Jerzy Kita, Monika Żychska, Anna Cywińska, Iwona Markowska-Daniel, Craig N. Carter, Lucjan Witkowski
Veterinary Diagnostic Laboratory Faculty Publications
Leptospirosis is one of the most common zoonotic infections worldwide, including in most livestock, some companion animals, horses, wildlife, and humans. Epidemiological estimation of its prevalence in all species is difficult due to the variety of clinical presentations and challenges regarding laboratory diagnosis. The purpose of this study was to measure the seroprevalence of leptospiral infection in Arabian horses kept in the largest breeding farms in Poland, representing over 15% of the Polish Arabian horse population. Leptospira antibodies were detected by MAT (cut-off 1:100) in 33.2% of serum samples (204 of 615 animals) (CI 95%: 29.6–37.0%), most frequently reacting with …
Lipidomic Analysis Of Immune Activation In Equine Leptospirosis And Leptospira-Vaccinated Horses, Paul L. Wood, Margaret Steinman, Erdal Erol, Craig Carter, Undine Christmann, Ashutosh Verma
Lipidomic Analysis Of Immune Activation In Equine Leptospirosis And Leptospira-Vaccinated Horses, Paul L. Wood, Margaret Steinman, Erdal Erol, Craig Carter, Undine Christmann, Ashutosh Verma
Veterinary Diagnostic Laboratory Faculty Publications
Currently available diagnostic assays for leptospirosis cannot differentiate vaccine from infection serum antibody. Several leptospiral proteins that are upregulated during infection have been described, but their utility as a diagnostic marker is still unclear. In this study, we undertook a lipidomics approach to determine if there are any differences in the serum lipid profiles of horses naturally infected with pathogenic Leptospira spp. and horses vaccinated against a commercially available bacterin. Utilizing a high-resolution mass spectrometry serum lipidomics analytical platform, we demonstrate that cyclic phosphatidic acids, diacylglycerols, and hydroperoxide oxidation products of choline plasmalogens are elevated in the serum of naturally …
Oas1 Polymorphisms Are Associated With Susceptibility To West Nile Encephalitis In Horses, Jonathan J. Rios, Joann G. W. Fleming, Uneeda K. Bryant, Craig N. Carter, John C. Huber Jr., Maureen T. Long, Thomas E. Spencer, David L. Adelson
Oas1 Polymorphisms Are Associated With Susceptibility To West Nile Encephalitis In Horses, Jonathan J. Rios, Joann G. W. Fleming, Uneeda K. Bryant, Craig N. Carter, John C. Huber Jr., Maureen T. Long, Thomas E. Spencer, David L. Adelson
Veterinary Diagnostic Laboratory Faculty Publications
West Nile virus, first identified within the United States in 1999, has since spread across the continental states and infected birds, humans and domestic animals, resulting in numerous deaths. Previous studies in mice identified the Oas1b gene, a member of the OAS/RNASEL innate immune system, as a determining factor for resistance to West Nile virus (WNV) infection. A recent case-control association study described mutations of human OAS1 associated with clinical susceptibility to WNV infection. Similar studies in horses, a particularly susceptible species, have been lacking, in part, because of the difficulty in collecting populations sufficiently homogenous in their infection and …