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Understanding Human Gut Bacterial Interactions And Their Role In Colonization Resistance Against Clostridioides Difficile Using Mini-Bioreactor Array And Caenorhabditis Elegans As Model Systems, Achuthan Ambat

Electronic Theses and Dissertations

Although fecal transplantation has shown to be effective against Clostridioides difficile infection (CDI), key species responsible for colonization resistance still need to be better identified. There needs to be more understanding of the rules governing the development of a healthy microbiome upon transplantation. The bottom-up approach of assembling simple to complex communities in model systems such as bioreactors is one of the ways to approach this problem. Studying synthetic communities with less complexity can yield a system-level understanding of microbial interactions. In the first study, we assembled a synthetic community of 14 bacterial species belonging to the core human microbiota …