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Passage Of Cd18- And Cd18+ Bovine Neutrophils Into Pulmonary Alveoli During Acute Pasteurella Haemolytica Pneumonia, Mark R. Ackermann, M. E. Kehrli Jr., K. A. Brogden

Mark R. Ackermann

CD18 is a subunit for three β2 integrin molecules (Mac-1, p150, 95, LFA-1), which are expressed on the plasma membrane of neutrophils. These molecules mediate passage of neutrophils into sites of infection. In children and animals that lack CD18 expression, neutrophil infiltration is impaired in most tissues. However, in lung, CD18-neutrophils have been identified in the airway spaces during spontaneous episodes of pneumonia. To determine whether CD18 is vital for passage through the pulmonary alveolar wall, lung lobes of cattle with neutrophils that were deficient in CD18 expression (CD18-) and cattle with normal CD18 expression (CD18+) were inoculated with Pasteurella …