Medicine and Health Sciences Commons^™

Comparison Of Infectious Complications In Patients Undergoing Transperineal Biopsy With And Without Antibiotic Prophylaxis, Steven Leonard, Emma Helstrom, Olutiwa Akinsola, Kristen R. Scarpato, Andres Correa

Tower Health Research Day

No abstract provided.

Microorganism Profiles Of Penile Prosthesis Removed For Infection, Erosion, And Mechanical Malfunction Based On Next-Generation Sequencing., Paul H Chung, Joon Yau Leong, Caleb D Phillips, Gerard D Henry

Department of Urology Faculty Papers

BACKGROUND: Next-generation sequencing (NGS) is an emerging technology that may allow for more sensitive and sophisticated microbial testing of the microbiota of penile prostheses (PP).

AIM: To describe the microorganism profiles of PP explanted for infection, erosion, and mechanical malfunction using NGS.

METHODS: All patients who underwent PP removal by two physicians at two institutions were identified. Differences in alpha diversity (ie, number of species detected, species diversity across samples) and microbiome compositional profiles (Bray-Curtis community dissimilarities) across samples were assessed using ANOVA and PERMANOVA, respectively.

OUTCOMES: Number of species detected, species diversity across samples, and microbiome compositional profiles.

RESULTS: …

Preventing Prostate Biopsy Complications: To Augment Or To Swab?, L. Glick, S. Vincent, T. M. Han, C. Caputo, D. Squadrito, J. Y. Leong, C. Fonshell, K. Syed, J. F. Danella, S. Ginzburg, T. J. Guzzo, M. Hagg, J. D. Raman, M. Smaldone, R. G. Uzzo, J. J. Tomaszewski, A. C. Reese, E. J. Trabulsi, L. G. Gomella, M. J. Mann

Health Equity and Quality Improvement (HEQI) Summit

Aims for Improvement

• The aim of this study was to determine the antibiotic prophylaxis associated with the fewest infectious complications following prostate biopsy
• Determining the safest method allows the Jefferson Department of Urology to modify its biopsy protocol and improve the rate of post-biopsy complications

Examining The Relationship Between Urinary Pathogens, Antibiotic Exposure And Urolithiasis, Jennifer Bjazevic

Electronic Thesis and Dissertation Repository

Urinary stone disease is a highly prevalent urological condition; however, the pathophysiology remains poorly understood. Growing evidence suggests a relationship between urinary tract infections, antibiotic exposure and the development of urolithiasis. In this project, we utilized a dietary Drosophila melanogaster model and a calcium oxalate crystal adhesion assay to further investigate the impact of a urinary pathogen and antibiotics on calcium stone formation. We demonstrated that both a non-urease producing strain of Escherichia coli and the antibiotics, ciprofloxacin and trimethoprim-sulfamethoxazole, increased calcium stone formation. In addition, our preliminary work suggests that biomineralization agents such as osteopontin and zinc appear to …

Feasability Of Preventing Encrustation Of Urinary Catheters, J. M. Bibby, A. J. Cox, D. W. L. Hukins

Cells and Materials

Colonization of urinary catheters by bacteria which produce urease leads to an increase in urine pH, followed by deposition of the minerals struvite and hydroxyapatite. Adhesion of these encrusting deposits can be reduced, but not prevented, by using catheters with a smooth surface finish. Chemical methods for preventing encrustation are not completely satisfactory. A better way of preventing encrustation would be to prevent colonization of the catheter by bacteria. This might be achieved by controlled release of antimicrobial agents directly into the urine from the catheter itself. Preliminary experiments have demonstrated the feasibility of controlled release from solid silicone. However, …