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Full-Text Articles in Medicine and Health Sciences
Muscarinic Agonists And Antagonists: Effects On The Urinary Bladder, Donna Sellers, Russ Chess-Williams
Muscarinic Agonists And Antagonists: Effects On The Urinary Bladder, Donna Sellers, Russ Chess-Williams
Donna Sellers
Voiding of the bladder is the result of a parasympathetic muscarinic receptor activation of the detrusor smooth muscle. However, the maintenance of continence and a normal bladder micturition cycle involves a complex interaction of cholinergic, adrenergic, nitrergic and peptidergic systems that is currently little understood. The cholinergic component of bladder control involves two systems, acetylcholine (ACh) released from parasympathetic nerves and ACh from non-neuronal cells within the urothelium. The actions of ACh on the bladder depend on the presence of muscarinic receptors that are located on the detrusor smooth muscle, where they cause direct (M3) and indirect (M2) contraction; pre-junctional …
Spontaneous Contractions Of The Pig Urinary Bladder: The Effect Of Atp-Sensitive Potassium Channels And The Role Of The Mucosa, Hironobu Akino, Christopher Chapple, Neil Mckay, Rebecca Cross, Shigetaka Murakami, Osamu Yokoyama, Russ Chess-Williams, Donna Sellers
Spontaneous Contractions Of The Pig Urinary Bladder: The Effect Of Atp-Sensitive Potassium Channels And The Role Of The Mucosa, Hironobu Akino, Christopher Chapple, Neil Mckay, Rebecca Cross, Shigetaka Murakami, Osamu Yokoyama, Russ Chess-Williams, Donna Sellers
Donna Sellers
To investigate the influence of the mucosa on the inhibitory effects of the ATP-sensitive potassium channel (KATP channel) opener, cromakalim, on the spontaneous contractions of pig bladder strips from the bladder dome and trigone. Little is known about the influence of the mucosa on spontaneous contractions and whether the nature of these contractions differs between the bladder dome and trigone.
MATERIALS AND METHODS
Paired longitudinal strips of female pig bladders were isolated from the dome and trigone. The mucosa was removed from one strip per pair and tissues were set up in organ baths. Spontaneous activity was allowed to develop …
The Beta3-Adrenoceptor Mediates The Inhibitory Effects Of Beta-Adrenoceptor Agonists Via The Urothelium In Pig Bladder Dome, Koichi Masunaga, Christopher Chapple, Neil Mckay, Masaki Yoshida, Donna Sellers
The Beta3-Adrenoceptor Mediates The Inhibitory Effects Of Beta-Adrenoceptor Agonists Via The Urothelium In Pig Bladder Dome, Koichi Masunaga, Christopher Chapple, Neil Mckay, Masaki Yoshida, Donna Sellers
Donna Sellers
Aims: Relaxation of detrusor muscle via b-adrenoceptors may contribute to urine storage during bladder filling. Thus there is increasing interest in b-adrenoceptor agonists as a potential treatment for detrusor overactivity. The role of the urothelium in bladder responses to b-adrenoceptor agonists is not yet clear, although we have shown that these agonists have a greater inhibitory effect on detrusor contraction when the urothelium is intact. The aim was to determine which b-adrenoceptor subtype is involved in this effect.
Methods: Paired strips of pig bladder dome mucosa-intact and mucosa-denuded, were mounted in tissue baths. Relaxation responses were obtained to b-adrenoceptor agonists …
Developments In The Pharmacotherapy Of The Overactive Bladder, Donna Sellers, Neil Mckay
Developments In The Pharmacotherapy Of The Overactive Bladder, Donna Sellers, Neil Mckay
Donna Sellers
Purpose of review
The overactive bladder is a common and distressing condition that has a significant impact on the quality of life of many people worldwide. Anticholinergics remain the first line in pharmacotherapy, however the use of these agents is hindered by adverse effects and limited efficacy. Thus there is a need for more effective treatments. Recently, there has been a move towards targeting novel pathways thought to play a role in overactivity. This review aims to provide an insight into the recent developments in pharmacotherapy of the overactive bladder.
Recent findings
With recent advances in our understanding of the …
Depressed Contractile Responses To Neurokinin A In Idiopathic But Not Neurogenic Overactive Human Detrusor Muscle, Donna Sellers, Christopher Chapple, Douglas Hay, Russell Chess-Williams
Depressed Contractile Responses To Neurokinin A In Idiopathic But Not Neurogenic Overactive Human Detrusor Muscle, Donna Sellers, Christopher Chapple, Douglas Hay, Russell Chess-Williams
Donna Sellers
Objective: The role of tachykinins such as neurokinin A in regulating bladder function is unclear, but NK2 receptors seem to mediate contraction in the human bladder and it has been suggested that these peptides may have a role in the pathophysiology of bladder dysfunction. The present study investigates neurokinin receptor-mediated contractility of detrusor muscle in the idiopathic overactive and neurogenic overactive bladder and investigates the neurokinin receptor subtypes involved.
Methods: Human bladder was obtained from patients undergoing cystectomy (normal) or clam cystoplasty (idiopathic overactive) and from patients with spinal injuries (neurogenic overactive). Strips of isolated detrusor muscle were mounted in …