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Microorganism Profiles Of Penile Prosthesis Removed For Infection, Erosion, And Mechanical Malfunction Based On Next-Generation Sequencing., Paul H Chung, Joon Yau Leong, Caleb D Phillips, Gerard D Henry
Microorganism Profiles Of Penile Prosthesis Removed For Infection, Erosion, And Mechanical Malfunction Based On Next-Generation Sequencing., Paul H Chung, Joon Yau Leong, Caleb D Phillips, Gerard D Henry
Department of Urology Faculty Papers
BACKGROUND: Next-generation sequencing (NGS) is an emerging technology that may allow for more sensitive and sophisticated microbial testing of the microbiota of penile prostheses (PP).
AIM: To describe the microorganism profiles of PP explanted for infection, erosion, and mechanical malfunction using NGS.
METHODS: All patients who underwent PP removal by two physicians at two institutions were identified. Differences in alpha diversity (ie, number of species detected, species diversity across samples) and microbiome compositional profiles (Bray-Curtis community dissimilarities) across samples were assessed using ANOVA and PERMANOVA, respectively.
OUTCOMES: Number of species detected, species diversity across samples, and microbiome compositional profiles.
RESULTS: …