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Is Allogeneic Stem Cell Transplantation Of High-Risk Pediatric Acute Lymphoblastic Leukemia (All) Patients More Effective In Preventing Future Relapses Of Disease And/ Or Mortality In Comparison With Chemotherapeutic Regimens Alone?, Patricia A. Ajizadeh
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not allogeneic SCT of HR pediatric ALL patients is more effective in preventing future relapses of disease and/or mortality in comparison with chemotherapeutic regimens alone.
STUDY DESIGN: Review of three English language primary randomized controlled trial studies published between 1996 and the present.
DATA SOURCES: Randomized controlled trial studies were found using PubMed.
OUTCOMES MEASURED: Each of the three studies evaluated the incidence of recurrent disease and/or mortality in high-risk pediatric ALL patients. These outcomes were analyzed according to the following categories: duration of event-free survival …