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Articles 1 - 8 of 8
Full-Text Articles in Medicine and Health Sciences
Neuroadaptive Changes In The Mesocortical Glutamatergic System During Nicotine Self-Administration And After Extinction In Rats, Fan Wang
Theses and Dissertations (ETD)
The mesocorticolimbic pathway is critical in almost all aspects of drug abuse, including nicotine. Though many of the neurochemical and molecular effects of nicotine have been well studied, nicotine’s long-term neuroadaptive effects, specifically within the mesocorticolimbic pathway, are largely undefined. Thus, in current study, we determined the neuroadaptive changes in the mesocortical glutamatergic system during chronic nicotine self-administration (SA), which emulates important aspects of nicotine intake by humans, and after extinction. In the initial study, after 18 days of nicotine SA, in the medial prefrontal cortex (mPFC), NMDA receptor subunit 2A (NR2A) and NR2B were increased by 67% and 83%, …
Role Of Medial Prefrontal Cortical Group Ii Metabotropic Glutamate Receptor In The Development Of Cocaine Sensitization, Xiaohu Xie
Theses and Dissertations (ETD)
The current studies examined the role of medial prefrontal cortical (mPFC) group II metabotropic glutamate receptors (mGluR2/3) in the development of cocaine sensitization. Initial studies demonstrated that intra-mPFC injection of the mGluR2/3 receptor agonist, APDC, dose-dependently reduced acute behavioral response to cocaine (0.015-15 nmol/side with significant effects starting at 1.5nmol/side). The effects of APDC were prevented by intra-mPFC co-injections of an mGluR2/3 antagonist, LY341495 (1.5 nmol/side). Repeated intra-mPFC APDC (1.5 nmol/side) injections also prevented the initiation of behavioral and neurochemical sensitization, which is defined as enhanced nucleus accumbens (NAc) dopamine response to cocaine. Once sensitization was …
Treatment Of Co-Morbid Methamphetamine Substance Abuse And Borderline Personality Disorder Features Using Modified Dialectical Behavior Therapy, Jessica R. Schultz Fischer
Treatment Of Co-Morbid Methamphetamine Substance Abuse And Borderline Personality Disorder Features Using Modified Dialectical Behavior Therapy, Jessica R. Schultz Fischer
Dissertations
The study investigated the effectiveness of a time-limited, skills-based treatment in a population of female substance abusers. This project implemented a pilot clinical trial to evaluate the effectiveness of a 12-session modified Dialectical Behavior Therapy (DBT) protocol among a small sample of women, with co-morbid borderline personality disorder features, receiving concurrent outpatient treatment for methamphetamine abuse. A non-concurrent multiple baseline design was used. In addition to on-going assessment conducted during baseline and weekly over the course of treatment, a comprehensive assessment battery was administered pre-, and post-treatment as well as at 1 and 3 months following treatment. Findings suggest that …
Adolescents And Marijuana Use: The Affects Of Peer And Parent Relationships And Substance Abuse Education., Samuel Joseph Cosimano
Adolescents And Marijuana Use: The Affects Of Peer And Parent Relationships And Substance Abuse Education., Samuel Joseph Cosimano
Electronic Theses and Dissertations
The purpose of this study was to analyze gender, race, substance abuse programs such as Drug Abuse Resistance Education (D.A.R.E.), parents, and peers and their ability to influence or predict adolescents and their decisions to use marijuana. All of the variables used for this study came from secondhand data collected by Esbensen and Osgood (1999), Gang Resistance Education and Training (G.R.E.A.T.). The analysis revealed that males are more likely to have ever used marijuana, that mixed race adolescents have a higher rate than other races to have ever used marijuana, that when adolescents complete the substance abuse program, D.A.R.E. have …
Social Workers' Knowledge Of Substance Abuse, Mirta Escobedo Johnson
Social Workers' Knowledge Of Substance Abuse, Mirta Escobedo Johnson
Theses Digitization Project
This study was designed to determine how knowledgeable child welfare social workers are of substance abuse when working with substance abusing clients. The results indicated that social workers within San Bernardino County have competent levels of knowledge in substance abuse which allow them to provide appropriate services to the community members they serve.
Risk Markers Associated With Physical And Psychological Abuse By Intimate Partners Against Women In Substance Abuse Treatment, Scott J. Buchanan
Risk Markers Associated With Physical And Psychological Abuse By Intimate Partners Against Women In Substance Abuse Treatment, Scott J. Buchanan
Seton Hall University Dissertations and Theses (ETDs)
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Why It Is Important To Look At Long-Term Abstinence From Heroin Use: A Review Life Beyond Heroin: An Exploration Of The Motivations For Long-Term Heroin Abstinence, Lucy Dann
Theses : Honours
The phenomenon of achieving long-term abstinence from drug use remains to be thoroughly understood in the alcohol and other drug (AOD) community, particularly in the area of heroin use. This review assesses research in the field of long-term abstinence from drug use and highlights the need to examine long-term abstinence from heroin use. Prochaska and DiClemente's (1986) Stages of Change model of behaviour change is examined as well as literature examining its importance in the AOD field. Studies examining long-term abstinence from alcohol, tobacco, cocaine and heroin use are reviewed from a psychological perspective, focusing on cognitive-behavioural constructs. Findings revealed …
Uncovering The Methadone Counseling Process Among Recovering And Non Recovering Chemical Dependency Counselors, Sara-Amanda Mccarthy, Jennifer Ann Palmersheim
Uncovering The Methadone Counseling Process Among Recovering And Non Recovering Chemical Dependency Counselors, Sara-Amanda Mccarthy, Jennifer Ann Palmersheim
Theses Digitization Project
The purpose of this study was to uncover the methadone counseling process among recovering and non-recovering chemical dependency counselors by examining the concepts and techniques utilized throughout the counseling process. This study examined whether the recovery status of a counselor affected the counselor's theoretical addiction model and the concepts and techniques that were utilized throughout the counseling process.