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Full-Text Articles in Medicine and Health Sciences
Perinatal Phencyclidine Treatment Alters Neuregulin 1/Erbb4 Expression And Activation In Later Life, Teresa M. Du Bois, Kelly Anne Newell, Xu-Feng Huang
Perinatal Phencyclidine Treatment Alters Neuregulin 1/Erbb4 Expression And Activation In Later Life, Teresa M. Du Bois, Kelly Anne Newell, Xu-Feng Huang
Faculty of Health and Behavioural Sciences - Papers (Archive)
Schizophrenia is a complex and devastating mental disorder of unknown etiology. Hypofunction of N-methyl-d-aspartate (NMDA) receptors are implicated in the disorder, since phencyclidine (PCP) and other NMDA receptor antagonists mimic schizophrenia-like symptoms in humans and animals so well. Moreover, genetic linkage and post mortem studies strongly suggest a role for altered neuregulin 1 (Nrg1)/erbB4 signaling in schizophrenia pathology. This study investigated the relationship between the NMDA receptor and Nrg1 signaling pathways using the perinatal PCP animal model. Rats (n = 5/group) were treated with PCP (10 mg/kg) or saline on postnatal days (PN) 7, 9 and 11 and were sacrificed …
Plasminogen Binding And Activation At The Breast Cancer Cell Surface: The Integral Role Of Urokinase Activity, Gillian E. Stillfried, Darren Saunders, Marie Ranson
Plasminogen Binding And Activation At The Breast Cancer Cell Surface: The Integral Role Of Urokinase Activity, Gillian E. Stillfried, Darren Saunders, Marie Ranson
Faculty of Health and Behavioural Sciences - Papers (Archive)
INTRODUCTION: The regulation of extracellular proteolytic activity via the plasminogen activation system is complex, involving numerous activators, inhibitors and receptors. Previous studies on monocytic and colon cell lines suggest that plasmin pre treatment can increase plasminogen binding, allowing the active enzyme to generate binding sites for its precursor. Other studies have shown the importance of pre formed receptors such as annexin II heterotetramer. However, few studies have utilised techniques which exclusively characterise cell surface events and these mechanisms have not been investigated at the breast cancer cell surface. METHODS: We have studied plasminogen binding to MCF 7 in which uPAR …
Arousal And Activation Effects On Physiological And Behavioral Responding During A Continuous Performance Task, Jacqueline A. Rushby, Robert J. Barry, Adam R. Clarke, Mohammad Vaezmousavi
Arousal And Activation Effects On Physiological And Behavioral Responding During A Continuous Performance Task, Jacqueline A. Rushby, Robert J. Barry, Adam R. Clarke, Mohammad Vaezmousavi
Faculty of Health and Behavioural Sciences - Papers (Archive)
Based on previous work indicating different neural substrates, two aspects of energetic state, arousal and activation, have been conceptualised separately in our laboratory. Arousal has been defined as the energetic state at any particular time, and task-related activation as the task-related change in state from resting baseline to the task situation. Both are reflected in electrodermal activity and measured by skin conductance level. Our previous studies in this area have indicated that physiological responses to stimuli in a task are dependent on the arousal level at the time of stimulus presentation, rather than the task-related activation. In contrast, performance on …