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Articles 1 - 18 of 18
Full-Text Articles in Medicine and Health Sciences
An Assessment Of The Use Of Chimpanzees In Hepatitis C Research Past, Present And Future: 2. Alternative Replacement Methods, Jarrod Bailey
An Assessment Of The Use Of Chimpanzees In Hepatitis C Research Past, Present And Future: 2. Alternative Replacement Methods, Jarrod Bailey
Experimentation Collection
The use of chimpanzees in hepatitis C virus (HCV) research was examined in the report associated with this paper (1: Validity of the Chimpanzee Model), in which it was concluded that claims of past necessity of chimpanzee use were exaggerated, and that claims of current and future indispensability were unjustifiable. Furthermore, given the serious scientific and ethical issues surrounding chimpanzee experimentation, it was proposed that it must now be considered redundant — particularly in light of the demonstrable contribution of alternative methods to past and current scientific progress, and the future promise that these methods hold. This paper builds on …
An Assessment Of The Use Of Chimpanzees In Hepatitis C Research Past, Present And Future: 1. Validity Of The Chimpanzee Model, Jarrod Bailey
An Assessment Of The Use Of Chimpanzees In Hepatitis C Research Past, Present And Future: 1. Validity Of The Chimpanzee Model, Jarrod Bailey
Experimentation Collection
The USA is the only significant user of chimpanzees in biomedical research in the world, since many countries have banned or limited the practice due to substantial ethical, economic and scientific concerns. Advocates of chimpanzee use cite hepatitis C research as a major reason for its necessity and continuation, in spite of supporting evidence that is scant and often anecdotal. This paper examines the scientific and ethical issues surrounding chimpanzee hepatitis C research, and concludes that claims of the necessity of chimpanzees in historical and future hepatitis C research are exaggerated and unjustifiable, respectively. The chimpanzee model has several major …
Human Induced Rotation And Reorganization Of The Brain Of Domestic Dogs, Taryn Roberts, Paul Mcgreevy, Michael Valenzuela
Human Induced Rotation And Reorganization Of The Brain Of Domestic Dogs, Taryn Roberts, Paul Mcgreevy, Michael Valenzuela
Anatomy Collection
Domestic dogs exhibit an extraordinary degree of morphological diversity. Such breed-to-breed variability applies equally to the canine skull, however little is known about whether this translates to systematic differences in cerebral organization. By looking at the paramedian sagittal magnetic resonance image slice of canine brains across a range of animals with different skull shapes (N = 13), we found that the relative reduction in skull length compared to width (measured by Cephalic Index) was significantly correlated to a progressive ventral pitching of the primary longitudinal brain axis (r = 0.83), as well as with a ventral shift in the position …
Human Induced Rotation And Reorganization Of The Brain Of Domestic Dogs, Taryn Roberts, Paul Mcgreevy, Michael Valenzuela
Human Induced Rotation And Reorganization Of The Brain Of Domestic Dogs, Taryn Roberts, Paul Mcgreevy, Michael Valenzuela
Morphology Collection
Domestic dogs exhibit an extraordinary degree of morphological diversity. Such breed-to-breed variability applies equally to the canine skull, however little is known about whether this translates to systematic differences in cerebral organization. By looking at the paramedian sagittal magnetic resonance image slice of canine brains across a range of animals with different skull shapes (N = 13), we found that the relative reduction in skull length compared to width (measured by Cephalic Index) was significantly correlated to a progressive ventral pitching of the primary longitudinal brain axis (r = 0.83), as well as with a ventral shift in the position …
The Vision Of Toxicity Testing In The 21st Century: Moving From Discussion To Action, Melvin E. Andersen, Daniel Krewski
The Vision Of Toxicity Testing In The 21st Century: Moving From Discussion To Action, Melvin E. Andersen, Daniel Krewski
Toxicology and Animal Models in Research Collection
Over the past year, a series on commentaries have appeared in the Toxicological Sciences Forum Series related to the 2007 National Research Council (NRC) publication, Toxicity Testing in the 21st Century: A Vision and A Strategy. The first article in the series provided an overview of the vision and was accompanied by an editorial by the three editors of Toxicological Sciences. During the past year, eight invited commentaries from the academic, industrial, and regulatory sectors have provided diverse perspectives on the vision, noted challenges to its implementation, and highlighted aspects of toxicity testing that were not addressed in …
Cross-Sector Review Of Drivers And Available 3rs Approaches For Acute Systemic Toxicity Testing, Troy Seidle, Sally Robinson, Tom Holmes, Stuart Creton, Pilar Prieto, Julia Scheel, Magda Chlebus
Cross-Sector Review Of Drivers And Available 3rs Approaches For Acute Systemic Toxicity Testing, Troy Seidle, Sally Robinson, Tom Holmes, Stuart Creton, Pilar Prieto, Julia Scheel, Magda Chlebus
Experimentation Collection
Acute systemic toxicity studies are carried out in many sectors in which synthetic chemicals are manufactured or used and are among the most criticized of all toxicology tests on both scientific and ethical grounds. A review of the drivers for acute toxicity testing within the pharmaceutical industry led to a paradigm shift whereby in vivo acute toxicity data are no longer routinely required in advance of human clinical trials. Based on this experience, the following review was undertaken to identify (1) regulatory and scientific drivers for acute toxicity testing in other industrial sectors, (2) activities aimed at replacing, reducing, or …
Your Attention Please: Increasing Ambient Noise Levels Elicits A Change In Communication Behaviour In Humpback Whales (Megaptera Novaeangliae), Rebecca A. Dunlop, Douglas H. Cato, Michael J. Noad
Your Attention Please: Increasing Ambient Noise Levels Elicits A Change In Communication Behaviour In Humpback Whales (Megaptera Novaeangliae), Rebecca A. Dunlop, Douglas H. Cato, Michael J. Noad
Bioacoustics Collection
High background noise is an important obstacle in successful signal detection and perception of an intended acoustic signal. To overcome this problem, many animals modify their acoustic signal by increasing the repetition rate, duration, amplitude or frequency range of the signal. An alternative method to ensure successful signal reception, yet to be tested in animals, involves the use of two different types of signal, where one signal type may enhance the other in periods of high background noise. Humpback whale communication signals comprise two different types: vocal signals, and surface-generated signals such as ‘breaching’ or ‘pectoral slapping’. We found that …
A Modular One-Generation Reproduction Study As A Flexible Testing System For Regulatory Safety Assessment, Richard Vogel, Troy Seidle, Horst Spielmann
A Modular One-Generation Reproduction Study As A Flexible Testing System For Regulatory Safety Assessment, Richard Vogel, Troy Seidle, Horst Spielmann
Experimentation Collection
The European Union’s Registration, Evaluation and Authorisation of Chemicals (REACH) legislation mandates testing and evaluation of approximately 30,000 existing substances within a short period of time, beginning with the most widely used “high production volume” (HPV) chemicals. REACH testing requirements for the roughly 3000 HPV chemicals specify three separate tests for reproductive toxicity: two developmental toxicity studies on different animal species (OECD Test Guideline 414) and a two-generation reproduction toxicity study (OECD TG 416). These studies are highly costly in both economic and animal welfare terms. OECD TG 416 is a fertility study intended to evaluate reproductive performance of animals …
Hair Whorls In The Dog (Canis Familiaris), Part Ii: Asymmetries, Lisa M. Tomkins, Paul Mcgreevy
Hair Whorls In The Dog (Canis Familiaris), Part Ii: Asymmetries, Lisa M. Tomkins, Paul Mcgreevy
Anatomy Collection
In horses and cattle, hair whorls have been shown to act as a structural marker of reactivity and behavioral lateralization. Few studies on canine whorls have been reported and none have assessed whorl position or direction of flow. This study describes the distribution and characteristics of whorl in each of 10 regions in which whorls are typically located in dogs. Hair whorls were assessed in dogs (n = 120) and were recorded as clockwise or counterclockwise in the cephalic, cervical (dorsal, lateral, ventral), thoracic and brachial axillary, chest, shoulders, elbows, abdominal, and ischiatic regions. Bilateral whorls, including brachial axillary, elbow, …
Hair Whorls In The Dog (Canisfamiliaris). I. Distribution, Lisa M. Tomkins, Paul Mcgreevy
Hair Whorls In The Dog (Canisfamiliaris). I. Distribution, Lisa M. Tomkins, Paul Mcgreevy
Anatomy Collection
Hair whorl characteristics were assessed in the domestic dog (Canis familiaris) in the regions of cephalic, cervical (dorsal, ventral, and lateral), thoracic and brachial axillary regions, the chest, shoulders, elbows, ventral abdominal region, and on the caudal thighs (ischiatic). They were classified as simple or tufted, and their position was recorded as the distance between their centers and bony landmarks within each region. The distribution of whorls was explored in a cohort of domestic dogs (N = 120) comprising a variety of breeds and cross‐breeds, sourced from shelters (N = 60) and the general public (N = 60). …
About Turkeys, The Humane Society Of The United States
About Turkeys, The Humane Society Of The United States
Agribusiness Collection
John James Audubon, a well-known bird expert and nature enthusiast, described wild turkeys as birds of great beauty. The history and origin of wild turkeys is uncertain, yet many share Audubon’s sentiment that the wild turkey is “one of the most interesting of the birds indigenous to the United States of America.” Today, wild turkeys can be found throughout the nation. Following the selection of the bald eagle as the American symbol, Benjamin Franklin remarked that the turkey was more “respectable”, and a “true original native”.
The Public Health Impacts Of Concentrated Animal Feeding Operations On Local Communities, Michael Greger, Gowri Koneswaran
The Public Health Impacts Of Concentrated Animal Feeding Operations On Local Communities, Michael Greger, Gowri Koneswaran
Environment Collection
Large-scale farm animal production facilities, also known as concentrated animal feeding operations (CAFOs), release a significant amount of contaminants into the air and water. Adverse health effects related to exposure to these contaminants among CAFO workers have been welldocumented; however, less is known about their impact on the health of residents in nearby communities. Epidemiological research in this area suggests that neighboring residents are at increased risk of developing neurobehavioral symptoms and respiratory illnesses, including asthma. Additional research is needed to better understand community-scale exposures and health outcomes related to the management practices and emissions of CAFOs.
Identification Of Parelaphostrongylus Odocoilei (Nematoda: Protostrongylidae) First-Stage Larvae In The Feces Of Gray Wolves (Canis Lupus) By Molecular Methods, Heather M. Bryan, Kathrin A. Sim, Chris T. Darimont, Paul C. Paquet, Brent Wagner, Violeta Muñoz-Fuentes, Judit E. Smits, Nell B. Chilton
Identification Of Parelaphostrongylus Odocoilei (Nematoda: Protostrongylidae) First-Stage Larvae In The Feces Of Gray Wolves (Canis Lupus) By Molecular Methods, Heather M. Bryan, Kathrin A. Sim, Chris T. Darimont, Paul C. Paquet, Brent Wagner, Violeta Muñoz-Fuentes, Judit E. Smits, Nell B. Chilton
Parasitology Collection
First-stage nematode larvae with a dorsal-spine (DSL) were detected in five of 1,565 fecal samples from gray wolves (Canis lupus) collected in British Columbia, Canada, between 2005 and 2008. Molecular techniques were used to identify the DSL because it was not possible to determine their species identity using morphologic characters. The DSL were identified as Parelaphostrongylus odocoilei based on the results of single-strand conformation polymorphism (SSCP) analyses and DNA sequencing of the ribosomal DNA first and second internal transcribed spacers. Finding DSL of P. odocoilei in the feces of gray wolves was unexpected because P. odocoilei adults are parasites of …
Toward Genuine Rodent Welfare: Response To Reviewer Comments, Jonathan P. Balcombe
Toward Genuine Rodent Welfare: Response To Reviewer Comments, Jonathan P. Balcombe
Laboratory Experiments Collection
I’m grateful to the editors for soliciting critiques of my commentary and for the opportunity to respond. Because one of the respondents (Patterson-Kane, 2010/this issue) does not take issue with the main points of my article, whereas the other (Blanchard, 2010/this issue) does, I focus my remarks here mostly on Blanchard’s critique.
About Fish, Humane Society Institute For Science And Policy
About Fish, Humane Society Institute For Science And Policy
Aquaculture Collection
Although a number of fish species have been studied in their freshwater life stages, further research on the behavior and habitat requirements of ocean-going fish is required. While fishes have historically been regarded as more “primitive” than other vertebrate groups, Rodriguez et al concluded that several memory and learning systems of bony fishes are noticeably similar to those of reptiles, birds, and mammals. When animals as small and under appreciated as fish display complex mating systems, parental care, and demonstrate the ability to traverse significant distances using olfactory and celestial cues, it is clear that previously established definitions of intelligence …
Non-Invasive Methods Of Identifying And Tracking Wild Squid, Ruth A. Byrne, James B. Wood, Roland C. Anderson, Ulrike Griebel, Jennifer A. Mather
Non-Invasive Methods Of Identifying And Tracking Wild Squid, Ruth A. Byrne, James B. Wood, Roland C. Anderson, Ulrike Griebel, Jennifer A. Mather
Morality and Ethics of Animal Experimentation Collection
The ability to identify individual free-living animals in the field is an important method for studying their behavior. Apart from invasive external or internal tags, which may cause injury or abnormal behavior, most cephalopods cannot be tagged, as their skin is too soft and delicate for tag retention. Additionally, cephalopods remove many types of tags. However, body markings have been successfully used as a non invasive method to identify individuals of many different species of animals, including whale sharks, grey whales, seals, and zebras. We developed methods to sex and individually identify Caribbean reef squid, Sepiotheuthis sepioidea. Males showed distinct …
Practical Considerations In Regenerative Medicine Research: Iacucs, Ethics, And The Use Of Animals In Stem Cell Studies, Susan Vandewoude, Bernard E. Rollin
Practical Considerations In Regenerative Medicine Research: Iacucs, Ethics, And The Use Of Animals In Stem Cell Studies, Susan Vandewoude, Bernard E. Rollin
Biomedicine and Animal Models in Research Collection
The intent of US federal laws mandating IACUC review of animal-related activities was to satisfy contemporary socioethical concerns by introducing deliberations about ethics and animal welfare into the research process when animals are used. These laws and the system they chartered have worked well for the most part in providing opportunities for consideration of animal welfare as a vital part of animal research. As a result, investigators today are far less naïve about the ethical issues raised by research on animals and typically more sympathetic about the need for such consideration. As evidence of this growing awareness, the literature on …
About Chickens, The Humane Society Of The United States
About Chickens, The Humane Society Of The United States
Agribusiness Collection
The chicken is the world’s most numerous domesticated bird, with over 52 billion farmed worldwide in 2008, rivaling the dog as the most ubiquitous domestic animal globally. These birds have fascinated scholars and researchers since the dawn of Western civilization, and recent studies are beginning to reveal the depths of their complexity and cognitive ability. According to Andrew F. Fraser, professor of veterinary surgery at Memorial University of Newfoundland, and Donald M. Broom, professor of animal welfare at University of Cambridge: “Those who have studied the behaviour of the domestic fowl in detail…, especially those who have looked at feral …