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Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
Cerebellum-Seeded Functional Connectivity Changes In Trait-Anxious Individuals Undergoing Attention Bias Modification Training, Katherine Elwell
Cerebellum-Seeded Functional Connectivity Changes In Trait-Anxious Individuals Undergoing Attention Bias Modification Training, Katherine Elwell
All NMU Master's Theses
Anxiety and anxiety related disorders are increasing at a drastic rate in the past decade, with the NIMH reporting that 31.1% of U.S. adults will experience an anxiety disorder at some point in their lives. Anxiety is commonly characterized by increased attention bias to threat. Attention Bias Modification (ABM) is a new treatment used to reduce individual’s attention bias towards threat. The extent to which ABM leads to underlying neural changes is still unknown. The cerebellum is a neglected brain structure, with new research provides evidence that cerebellum’s functional connectivity and shared networks with threat processing regions has a direct …
Discriminative Stimulus Effects Of Putative Antipsychotic Drugs, Alex Lekander
Discriminative Stimulus Effects Of Putative Antipsychotic Drugs, Alex Lekander
All NMU Master's Theses
This study attempted to further explore the discriminative stimulus properties of antipsychotic drugs, by establishing the typical antipsychotic drug chlorpromazine, and the atypical antipsychotic drug clozapine as discriminative stimulus in two different groups of rats. The rats trained to discriminate chlorpromazine from vehicle failed to do so reliably, however nine of ten rats trained to discriminate 1.25 mg/kg clozapine from vehicle were able to acquire the discrimination in 19.1 sessions. The clozapine cue partially generalized (63.13% drug lever responding [SEM = ± 18.91]) to the antimalarial drug methylene blue at the 7.5 mg/kg dose, but not to the antimalarial quinacrine. …
Effects Of Norharmane And Nicotine On The Conditioned Place Preference Of Mice, Lindsey Galbo
Effects Of Norharmane And Nicotine On The Conditioned Place Preference Of Mice, Lindsey Galbo
All NMU Master's Theses
Tobacco smoking in the United States is used by approximately 25% of adults. Many studies using animal models have suggested that nicotine has rewarding properties. Contrastingly, several studies have also found it to be a weakly reinforcing substance at low and high dose levels. Due to this, other tobacco constituents, such as the monoamine oxidase inhibitor norharmane which is found in tobacco leaf and smoke, may be responsible for tobacco addiction by potentiating the rewarding properties of nicotine. Several studies have attempted to observe this phenomenon, however, monoamine oxidase inhibitors that are not found in tobacco leaf or smoke have …
Characterization Of Transmembrane Protein 35 Expression: Considerations Of Sex And Ovarian Hormones, Amanda M. Vanderplow
Characterization Of Transmembrane Protein 35 Expression: Considerations Of Sex And Ovarian Hormones, Amanda M. Vanderplow
All NMU Master's Theses
The recently discovered novel neuropeptide transmembrane protein 35 (TMEM35), is believed to modulate chemical signaling within the nervous system. Notably, the TMEM35 protein is detectable in humans, non-human primates and rodents, suggesting a conserved and critical function. Despite this, the functions of TMEM35 are ill-defined in the nervous system and insufficiently studied (currently only three publications). Previous work has identified high expression of TMEM35 in both the ventromedial hypothalamus (VMH) and the limbic circuit of the mouse brain. Due to the known functions of these two regions, this pattern of expression indicates possible roles of this neuropeptide in social behavior …
Intracranial Infusions Of Neurotensin Agonists Produce An Anxiolytic Profile In A Rat Ultrasonic Vocalization Model, Floyd F. Steele Iii
Intracranial Infusions Of Neurotensin Agonists Produce An Anxiolytic Profile In A Rat Ultrasonic Vocalization Model, Floyd F. Steele Iii
All NMU Master's Theses
Neurotensin (NT) is a peptide neurotransmitter that interacts with brain monoamine neurotransmitter systems. It has been demonstrated that neurotensin type 1 and type 2 receptor agonists influence animal models of psychological disorders and pain regulation, respectively. It has already been shown that the systemic administration of the selective neurotensin type 1 receptor agonist PD149163 can attenuate the number of fear-induced 22-kHz ultrasonic vocalizations (USVs) produced by male Wistar rats. A reduction in the number of 22-kHz USV calls is indicative of an anxiolytic effect. The current study used a USV model to evaluate the effects of PD149163 (0.1, 1.0, and …
Haptic And Exoskeleton Devices For Neurorehabilitation Of Upper Limb Paralysis: A State Of Art And A Night Landing Task, Samantha Renee Wagner
Haptic And Exoskeleton Devices For Neurorehabilitation Of Upper Limb Paralysis: A State Of Art And A Night Landing Task, Samantha Renee Wagner
All NMU Master's Theses
Rehabilitation is an important training phase for those suffering from upper limb paralysis as a result of brain injury. When successfully completed, the re-trained limb should be able to successfully complete daily life activities. An alternative to traditional therapy is the usage of effective rehabilitation by using haptic devices in a virtual environment. The type of haptic device and task are crucial for the success of the therapy training sessions. After presenting a state-of-art literature review of several haptic devices that has been used in research and clinical facilities, we thought to use the black hole illusion (BHI), a night …