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Full-Text Articles in Medicine and Health Sciences
[Studies On Keratocystic Odontogenic Tumors], T. Li, L. Sun, H. Luo, J. Luan, L. Gao, Xiaomei Gu, X. Li, L. Xu
[Studies On Keratocystic Odontogenic Tumors], T. Li, L. Sun, H. Luo, J. Luan, L. Gao, Xiaomei Gu, X. Li, L. Xu
Xiaomei Gu
Keratocystic odontogenic tumors (KCOTs, previously known as odontogenic keratocysts) are aggressive, noninflammatory jaw lesions with a putative high growth potential and a propensity for recurrence. This article puts together a summary of the serial studies related to KCOTs undertaken by the author's research group in recent years. Intraosseous jaw cysts with a solely orthokeratinized lining epithelium have been suggested to differ from the typical KCOTs. We report 20 cases of such cyst type under the term of 'orthokeratinized odontogenic cyst (OOC)'. Apart from the presence of a keratinizing epithelial lining, the OOC lacks the other histological features of KCOT, exhibits …
Librarians' Roles In Evidence-Based Dentistry Education: A Review Of Literature And A Survey In North America, Xiaomei Gu
Xiaomei Gu
This study describes the current roles of dental librarians in Evidence-based Dentistry (EBD) education including their perceptions of EBD and barriers to their involvement. A Web-based survey was distributed to the dental librarians in North America, with a 71% response rate. The results showed that the majority of dental librarians are playing multiple and diverse roles in EBD education. The most frequently cited barrier to their involvement is the low level of interest from the dental faculty/student/school. Most dental librarians felt competent in supporting EBD, although continuing education needs in both EBD and teaching skills were pointed out.
Ptch Mutations In Sporadic And Gorlin-Syndrome-Related Odontogenic Keratocysts, Xiaomei Gu, H. Zhao, L. Sun, T. Li
Ptch Mutations In Sporadic And Gorlin-Syndrome-Related Odontogenic Keratocysts, Xiaomei Gu, H. Zhao, L. Sun, T. Li
Xiaomei Gu
Odontogenic keratocysts are relatively common lesions that may occur in isolation or in association with nevoid basal cell carcinoma syndrome (or Gorlin syndrome). The PTCH gene has been reported to be associated with Gorlin syndrome. We investigated 10 cases of non-syndromic keratocysts and two other cases associated with Gorlin syndrome, looking for PTCH mutations. Four novel and 1 known PTCH mutations were identified in five individual patients. Of the 5 mutations identified, 2 were germ-line mutations (2619C>A; 1338_1339insGCG) in 2 cysts associated with Gorlin syndrome, and 3 were somatic mutations (3124_3129dupGTGTGC; 1361_1364delGTCT; 3913G>T) in 3 non-syndromic cysts. This …
Ptch Germline Mutations In Chinese Nevoid Basal Cell Carcinoma Syndrome Patients, T. Li, J. Yuan, Xiaomei Gu, L. Sun, H. Zhao
Ptch Germline Mutations In Chinese Nevoid Basal Cell Carcinoma Syndrome Patients, T. Li, J. Yuan, Xiaomei Gu, L. Sun, H. Zhao
Xiaomei Gu
Objectives: PTCH, the human homologue of the Drosophila segment polarity gene, patched, has been identified as the gene responsible for nevoid basal cell carcinoma syndrome. The aim of this study was to investigate PTCH gene mutation in Chinese patients with nevoid basal cell carcinoma syndrome. Materials and methods: DNA was isolated from both odontogenic keratocyst tissue and peripheral blood of five patients with syndrome and one patient with only multiple odontogenic keratocysts, and mutational analysis of the PTCH gene performed by direct sequencing after amplification of all 23 exons by polymerase chain reaction (PCR). Results: A previously reported germline mutation …
[Detection Of Ptch Gene Mutations In Odontogenic Keratocysts By Sscp And Dna Sequencing], Xiaomei Gu, T Li
[Detection Of Ptch Gene Mutations In Odontogenic Keratocysts By Sscp And Dna Sequencing], Xiaomei Gu, T Li
Xiaomei Gu
OBJECTIVE: To investigate PTCH gene mutations in odontogenic keratocysts (OKC). METHODS: PCR-SSCP and DNA sequencing were used to analyze the PTCH gene mutations in 12 OKCs, including 10 sporadic and 2 nevoid basal cell carcinoma syndrome (NBCCS) associated OKC. RESULTS: Four mutations were identified in 4 cysts, among which two germline mutations were associated with NBCCS and 2 somatic mutations were in 2 unrelated sporadic cases. In addition, eight previously reported polymorphisms in the PTCH gene were also found in 10 cases. CONCLUSION: The present study indicated that both sporadic and NBCCS-related OKCs could carry PTCH gene mutation. Thus, mutational …