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Effects Of Intraarticular Botulinum Toxin A In The Treatment Of Ankle Osteoarthritis, Shu-Fen Sun, Chien-Wei Hsu, Yi-Jiun Chou, Yu-Nong Wang, Chiao-Wen Hwang, Mei-Chia Chou, Jue-Long Wang

Rehabilitation Practice and Science

Background: Preliminary evidence suggests that Botulinum toxin type A (BoNT-A) injected intraarticularly into painful joints has a significant nociceptive effect. The purpose of this study is to investigate the effects of intraarticular BoNT-A on the pain and physical function for patients with ankle osteoarthritis (OA).Method: A prospective study with 6 months follow-up done in a university-affiliated tertiary care medical center, patients with symptoms and radiographic evidence of ankle OA for at least 6 months were recruited. Patients received intraarticular injections of 100 units of BoNT-A in 2 cc of normal saline. The injections were performed by the same experienced doctor. …