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Bpc 157 Promotes Skeletal Muscle Cells Migration In Association With Up-Regulation Of Paxillin And Vinculin Expression, Szu-Heng Wang, Li-Ping Lin, Miao-Sui Lin, Jong-Hwei S. Pang, Wen-Chung Tsai
Bpc 157 Promotes Skeletal Muscle Cells Migration In Association With Up-Regulation Of Paxillin And Vinculin Expression, Szu-Heng Wang, Li-Ping Lin, Miao-Sui Lin, Jong-Hwei S. Pang, Wen-Chung Tsai
Rehabilitation Practice and Science
BPC 157 was first isolated from human gastric juice. It is a stable 15-amino acid fragment (GEPPPGKPADDAGLV), and the healing-promoting effects of BPC 157 have been reported on muscle injury. The aim of this study was to investigate the effect and molecular mechanism of BPC 157 on migration of skeletal muscle cells. Skeletal muscle cells were isolated from the gastrocnemius muscle of Sprague-Dawley rats, and treated with BPC 157. The cell migration was evaluated by transwell filter migration assay. The spreading of cells was evaluated microscopically. The protein expressions of paxillin and vinculin (which were positive regulators of cell migration) …