Medicine and Health Sciences Commons^™

Fragile X Syndrome And Family Occupations: Sertraline Treatment Via Case Studies, Decerie Mendoza, Tracy P. Ye, Martina C. Dualan, Elena A. Javier

Student Research Posters

Current research on children with Fragile X Syndrome (FXS) lacks inclusion of qualitative outcomes on the child’s daily occupational performance. Standardized measurements are frequently utilized and provide useful information, however, can be less sensitive to change (Berry Kravis et al., 2013) and miss capturing family perspectives and improvements within meaningful occupations. This research incorporates family perspectives via semi-structured interviews to promote an in-depth understanding about FXS and its impact on child and family occupations in addition to standardized assessment scores through in-depth case study analysis. This study used a mixed method research design examining four male participants who were given …

Living With Fragile X Syndrome: Occupations As An Outcome Measure In A Clinical Trial, Theresa Chase, Ty Duong, Ana Baldinger, Kaylee Gothelf

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of this study was to evaluate the use of semi-structured interviews as an outcome measure in a clinical trial for children with fragile X syndrome (FXS). A qualitative approach was used to analyze twenty-five parent interviews with children with FXS who participated in a double-blind medication trial. Each participant received either sertraline or a placebo. The aim of this research was to assess differences in occupational functioning in the sertraline group and placebo group, that may not have been detected with the use quantitative outcome measures alone. Results showed greater improvements in the sertraline group in areas of …

Living With Fragile X Syndrome: Occupations As An Outcome Measure In A Clinical Trial, Kaylee E. Gothelf, Ty Duong, Ana Baldinger, Theresa Chase

Student Research Posters

The purpose of this study was to evaluate the use of semi-structured interviews as an outcome measure in a clinical trial for children with fragile X syndrome (FXS) ages 2-6. This qualitative approach was used to analyze twenty-five interviews of parents with children in a double-blind medication trial - sertraline or placebo. The aim was to assess occupational improvements in their child that may not have been detected with the use quantitative outcome measures alone. Results showed greater improvements in the sertraline group in areas of behavior, social participation, sensory-related behaviors, receptive language, education, family impact and therapeutic strategies. Our …

Effects Of Sertraline Treatment For Young Children With Fxs, Andrew Ligsay, Laura Greiss Hess, Sarah Fitzpatrick, Kerrie Lemons Chitwood, Jonathan Polussa, Salpi Siyahian, Randi Hagerman

Collected Faculty and Staff Scholarship

Selective serotonin reuptake inhibitors (SSRIs) help treat many of the phenotypic manifestations of fragile X syndrome (FXS) including anxiety, sensory processing challenges, and communication and intellectual deficits. However, the efficacy of SSRIs has not been previously studied in children with FXS under five-years-old. The purpose of this study was to elucidate group differences in behavior and developmental outcome measures for young children with FXS when treated with sertraline compared to placebo.

Effects Of Sertraline Treatment For Young Children With Fxs, Laura Greiss Hess, Peter Mundy, Randi Hagerman

Collected Faculty and Staff Scholarship

Phenotypic manifestations for young children with fragile X syndrome (FXS) include: anxiety, sensory processing challenges, global language and communication deficits and intellectual and developmental disabilities. Many of these symptoms can be treated with medications, including selective serotonin reuptake inhibitors (SSRIs). However to date a clinical trial has not been conducted for children under five years old.

This study investigated the following question: Are there group differences on developmental outcome measures for those children treated with sertraline compared to placebo?

Family Meanings, Contexts And Hopes Within A Clinical Trial, Laura Greis Hess, Cynthia Carter Ching, Randi Hagerman

Collected Faculty and Staff Scholarship

These qualitative analyses are a component of the clinical trial: “Effects of Sertraline Treatment for Young Children with FXS: Examination of Developmental Outcomes and Family Contexts.”

We argue that inclusion of a sociocultural perspective within the context of a clinical trial affords consideration of:

• A dynamic view of development – simultaneous consideration of biological and sociocultural factors (Vygotsky, 1978).
• Application of a bioecological framework and consideration of ever changing nested settings and contexts over time (Bronfenbrenner, 2005)