Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Public Health

Yale University

2018

Articles 1 - 2 of 2

Full-Text Articles in Medicine and Health Sciences

Risk For Cardiovascular Diseases In Prostate Cancer Patients Treated With Androgen Deprivation: A Population-Based Cohort Study, Lei Jiang May 2018

Risk For Cardiovascular Diseases In Prostate Cancer Patients Treated With Androgen Deprivation: A Population-Based Cohort Study, Lei Jiang

Public Health Theses

Background: Previous studies evaluating the risk of cardiovascular diseases (CVD) in prostate cancer patients receiving androgen deprivation treatment (ADT) often did not distinguish different types of ADT.

Methods: We conducted a large, retrospective cohort study using the linked Surveillance, Epidemiology and End Results - Medicare database, including patients with primary localized prostate cancer diagnosed in 2007--2013 and followed through the end of 2014. Time dependent multivariable Cox proportional hazards models with death as the competing risk were used to evaluate the association between ADT (overall, and two subtypes: gonadotropin-releasing hormone [GnRH] agonists and oral antiandrogens) and incidence of CVD. …


Coffee Drinking And Leukocyte Telomere Length: A Meta-Analysis, Bella Kotlyar Feb 2018

Coffee Drinking And Leukocyte Telomere Length: A Meta-Analysis, Bella Kotlyar

Yale Day of Data

Telomeres are long tandem nucleotide repeats responsible for maintaining chromosomal integrity. They shorten with each cell division, serving as markers for cellular aging and replicative ability, and shorter telomere length has been associated with greater risk of various chronic diseases of aging. There is increasing interest in the relationship between telomere length and lifestyle factors, such as components of the diet, that are associated with age-related chronic diseases, like cancer and diabetes.

There is mounting evidence that coffee, one of the most commonly consumed beverages in the world, has potential protective effects against chronic disease and mortality. Few studies have …