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Impact Of Obesity And Expression Of Obesity-Related Genes In The Progression Of Prostate Cancer In African American Men, Mmadili Nancy Ilozumba
Impact Of Obesity And Expression Of Obesity-Related Genes In The Progression Of Prostate Cancer In African American Men, Mmadili Nancy Ilozumba
USF Tampa Graduate Theses and Dissertations
In the US, the incidence and mortality rates of prostate cancer (PCa) are higher among African American men compared to European American men. Obesity is an important risk factor of PCa. Obesity is known to alter the gene expression profiles in prostate tumors. This study evaluates the impact of obesity and the expression of obesity-related genes on the progression of PCa in African American men.
The primary outcome of interest is biochemical recurrence (BCR) of PCa. There were 48 African American prostate cancer patients in the study. The tissue samples included 42 normal tissues, 40 Prostate Intraepithelial Neoplasia (PIN) and …