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Independent Evolution Of Macrophage-Tropism And Increased Charge Between Hiv-1 R5 Envelopes Present In Brain And Immune Tissue, Maria Paz Gonzalez-Perez, Olivia O’Connell, Rongheng Lin, W Matthew Sullivan, Jeanne Bell, Peter Simmonds, Paul R. Clapham
Independent Evolution Of Macrophage-Tropism And Increased Charge Between Hiv-1 R5 Envelopes Present In Brain And Immune Tissue, Maria Paz Gonzalez-Perez, Olivia O’Connell, Rongheng Lin, W Matthew Sullivan, Jeanne Bell, Peter Simmonds, Paul R. Clapham
Rongheng Lin
Background: Transmitted HIV-1 clade B or C R5 viruses have been reported to infect macrophages inefficiently, while other studies have described R5 viruses in late disease with either an enhanced macrophage-tropism or carrying envelopes with an increased positive charge and fitness. In contrast, our previous data suggested that viruses carrying non-macrophage-tropic R5 envelopes were still predominant in immune tissue of AIDS patients. To further investigate the tropism and charge of HIV-1 viruses in late disease, we evaluated the properties of HIV-1 envelopes amplified from immune and brain tissues of AIDS patients with neurological complications. Results: Almost all envelopes amplified were …