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Full-Text Articles in Medicine and Health Sciences
Studies Of Amino Acid Mutations In Drug Resistance Of The Smo Protein, Eunice Wintona
Studies Of Amino Acid Mutations In Drug Resistance Of The Smo Protein, Eunice Wintona
UNO Student Research and Creative Activity Fair
Smoothened receptor (SMO) is a protein that in humans, is encoded by the SMO gene. A systemic mutation in its binding pocket helps predict the sensitivity of mutant proteins to different drugs. Known as a GPCR-like receptor, it is a component of the hedgehog signaling pathway; a pathway involved in body patterning and the regulation of adult stem cells. An uncontrolled or inappropriate activation of the Hedgehog pathway drives tumor progression in cancers and a number of birth defects. To achieve these goals, the molecular modeling software MOE was used to build small molecules and drug molecules like Vismodegib and …
Can The Scale-Free Networks, Improve The Prediction Of Pertussis Infection Rates?, Kimia Ameri
Can The Scale-Free Networks, Improve The Prediction Of Pertussis Infection Rates?, Kimia Ameri
UNO Student Research and Creative Activity Fair
Whooping cough is a highly contagious disease with randomness pattern of infection. Outbreaks of whooping cough have increased over the past few years and has drawn the attention of health care providers. Understanding the spread mechanisms of contagious disease is very important and timely. Extension of contagious disease depends on many complicated factors including pathogen and host environment, exposed population and their activities. In this work, we try to find best prediction for the exposed population. A new SEIR model based on network (NB-SEIR) proposed to improve the accuracy of prediction for number of infected individuals. For this purpose, the …