Medicine and Health Sciences Commons^™

Investigating Gene-Environment Interaction In A Double-Hit Model For Autism Spectrum Disorder, Melvin Maroon

Undergraduate Student Research Internships Conference

With the exponential advancements seen in the field of sequencing technology, the science community has come to identify hundreds of potential genetic risk factors for neuropsychiatric disorders. Despite our knowledge that such risk factors exist, we have yet to understand their specific influences on the behavioral profile of an individual. In addition, maternal infection during pregnancy can have longstanding detrimental outcomes on a child’s development. This is especially impactful with the present threat of viral infection during the pandemic. Our study aims to understand the influence of a specific genetic and environmental factor on a preclinical rodent model’s behavioral development. …

Different Pathways To Cognition: An Erp Investigation Of Enhanced Perceptual Functioning And Autistic Traits In School-Aged Children, Elizabeth Anne Kaplan-Kahn

Dissertations - ALL

Autistic individuals show enhanced perceptual functioning on a range of behavioral tasks. Neurophysiological evidence, from both fMRI and event related potential (ERP) studies, also supports the conclusion that autistic individuals utilize perceptual processes to a greater extent than neurotypical comparisons to support problem solving and reasoning. Despite substantial evidence supporting differential information processing streams in autism, the relationship between these processing streams and autistic traits is not well understood. One study has investigated the relationships between autistic traits, early perceptual ERPs, and subsequent cognitive ERPs in neurotypical adults; however, these relationships have yet to be explored in autistic and neurotypical …

An Evaluation Of Distributed And Accumulated Reinforcer Arrangements On Skill Acquisition And Preference, Natalie R. Mandel

USF Tampa Graduate Theses and Dissertations

Discrete trial training (DTT), an evidence-based instructional procedure (Wong et al., 2015), is often used to teach skills to individuals with autism. Manipulations to the reinforcement component of DTT have increased its instructional efficiency, resulting in acquisition of skills in less time (e.g., Cividini-Motta & Ahearn, 2013). Results of previous studies (e.g., DeLeon et al., 2014) indicate that some individuals prefer to complete larger work requirements that result in a larger amount of a reinforcer (i.e., accumulated arrangement), rather than receiving access to small amounts of a reinforcer dispersed throughout the work requirement (i.e., distributed arrangement). In addition, accumulated reinforcer …

Case Study: Using A Contingency-Based Delay Procedure To Decrease Tantrums During Periods Of Delayed Reinforcement, Lindsey Snyder

USF Tampa Graduate Theses and Dissertations

Functional Communication Training (FCT) involves reinforcing a functional communicative response (FCR) while placing problem behaviors on extinction (Carr & Durrand, 1985). When reinforcement for the FCR is delayed or unavailable, the individual’s problem behavior may return to previous levels (i.e., resurgence of previously reinforced problem behavior; Briggs et al., 2018) or the participant may exhibit emotional responding consistent with an extinction burst (Lerman & Iwata, 1996). A contingency-based delay procedure was introduced which increased the participant’s percentage of trials without tantrums and decreased the overall duration of tantrums.

Patterns Of Cilia Gene Dysregulations In Major Psychiatric Disorders, Wedad Alhassen, Siwei Chen, Marquis Vawter, Brianna Kay Robbins, Henry Nguyen, Thant Nyi Myint, Yumiko Saito, Anton Schulmann, Surya M. Nauli, Olivier Civelli, Pierre Baldi, Amal Alachkar

Pharmacy Faculty Articles and Research

Primary cilia function as cells' antennas to detect and transduce external stimuli and play crucial roles in cell signaling and communication. The vast majority of cilia genes that are causally linked with ciliopathies are also associated with neurological deficits, such as cognitive impairments. Yet, the roles of cilia dysfunctions in the pathogenesis of psychiatric disorders have not been studied. Our aim is to identify patterns of cilia gene dysregulation in the four major psychiatric disorders: schizophrenia (SCZ), autism spectrum disorder (ASD), bipolar disorder (BP), and major depressive disorder (MDD). For this purpose, we acquired differentially expressed genes (DEGs) from the …

An Evaluation Of Wayfinding Abilities In Adolescent And Young Adult Males With Autism Spectrum Disorder, Yingying Yang, Weijia Li, Dan Huang, Wei He, Yanxi Zhang, Edward Merrill

Department of Psychology Faculty Scholarship and Creative Works

Background

Wayfinding refers to traveling from place to place in the environment. Despite some research headway, it remains unclear whether individuals with Autism Spectrum Disorder (ASD) show strengths, weaknesses, or similarities in wayfinding compared with ability-matched typically developing (TD) controls.

Method

The current study tested 24 individuals with ASD, 24 mental-ability (MA) matched TD (MA-TD) controls, and 24 chronological-age (CA) matched TD (CA-TD) controls. Participants completed a route learning task and a survey learning task, both programmed in virtual environments, and a perspective taking task. Their parents completed questionnaires assessing their children’s everyday wayfinding activities and competence.

Results

Overall, CA-TD …

Ability Status, Self-Advocacy, And Individuals With Neurodevelopmental Disabilities: Neurodiversity-Informed Training For Professionals And Caregivers, Allison N. Simpson

Psychology Doctoral Specialization Projects

Ability status in U.S. society is a critical social and cultural identity. “Disability” is often viewed through the lens of pathology as an illness. This kind of view affects not only the personal identity of individuals with neurodevelopmental disabilities, but also their treatment by others in the community, employers, caregivers, and others in their system of interaction. Even individuals who are strong self-advocates can be silenced by this kind of lens. A more empowering way to view individuals with neurodevelopmental disabilities is through the lens of neurodiversity in order to see their abilities, needs, wishes, and lives. The current project …

An Overview Of Electronic Preference Assessments And Recommendations For Their Use In Telehealth, Giancarlo Anro

Cal Poly Humboldt theses and projects

Preference assessments are used to systematically determine an individuals preferred items to be used as potential reinforcers during service delivery. Electronic preference assessments typically do not use tangible items but instead present electronic representations of these tangible items, such as electronic pictures or videos, to the client. The purpose of this overview is to introduce the history and traditional use of electronic preference assessments and then to provide practical recommendations for using an electronic preference assessment while providing behavioral services through a telehealth model. When conducting an electronic preference assessment during a telehealth session two primary considerations need to be …