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Serotonin Transporter Promoter Polymorphism, Peripheral Indexes Of Serotonin Function, And Personality Measures In Families With Alcoholism, Scott F. Stoltenberg, Geoffrey R. Twitchell, Gregory L. Hanna, Edwin H. Cook, Hiram E. Fitzgerald, Robert A. Zucker, Karley Y. Little
Serotonin Transporter Promoter Polymorphism, Peripheral Indexes Of Serotonin Function, And Personality Measures In Families With Alcoholism, Scott F. Stoltenberg, Geoffrey R. Twitchell, Gregory L. Hanna, Edwin H. Cook, Hiram E. Fitzgerald, Robert A. Zucker, Karley Y. Little
Scott F. Stoltenberg
A functional polymorphism in the regulatory region of the serotonin transporter gene (5-HTTLPR) is considered to be a plausible candidate gene for anxiety-related personality traits and for alcoholism. Empirical support for the association between 5-HTTLPR and psychological traits has been somewhat inconsistent; however, observations of the functional dominance of the low-activity s-allele over the l-allele have been more consistent. When studying the influence of particular genes on psychological traits, it seems useful also to assess more biological intermediate traits that may mediate the effects of those genes on the traits of interest. The present study examined relationships between 5-HTTLPR genotype, …
Possible Association Between Response Inhibition And A Variant In The Brain-Expressed Tryptophan Hydroxylase-2 Gene, Scott Stoltenberg, Jennifer Glass, Steven Chermack, Heather Flynn, Sheng Li, Margaret Weston, Margit Burmeister
Possible Association Between Response Inhibition And A Variant In The Brain-Expressed Tryptophan Hydroxylase-2 Gene, Scott Stoltenberg, Jennifer Glass, Steven Chermack, Heather Flynn, Sheng Li, Margaret Weston, Margit Burmeister
Scott F. Stoltenberg
The ability to inhibit a response is an important component of normal behavioral control and is an aspect of psychopathology when diminished. Converging evidence implicates the serotonergic neurotransmitter system in response inhibition circuitry. Objectives — The present study examined potential associations between serotonergic genetic markers and response inhibition as indexed by Stop Task performance. Methods — College-age participants (N= 199) completed self-report questionnaires, the computerized Stop Task, and donated buccal cells for genetic analyses. Statistics were analyzed by ANOVA. Results — Stop Signal reaction time was not associated with allelic variation at a monoamine oxidase A promoter length polymorphism or …