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- Conditioned avoidance response (4)
- Olanzapine (3)
- Rat (3)
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- Repeated antipsychotic treatment (2)
- Risperidone (2)
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- 22 kHz ultrasonic vocalizations (1)
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- Adolescent rat; nicotine; motor activity; prepulse inhibition of acoustic startle (1)
- Amphetamine (1)
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- Amphetamine; Phencyclidine; Antipsychotic drug; Anxiolytic drug; Hyperlocomotor activity; Schizophrenia; Animal models of schizophrenia (1)
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- Avoidance conditioning (1)
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- Conditioned avoidance response; drug memory; haloperidol; interoceptive drug state; olanzapine; rat; risperidone (1)
- D2/3 receptor (1)
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- Drug addiction (1)
- Drug-drug conditioning (1)
Articles 1 - 14 of 14
Full-Text Articles in Medicine and Health Sciences
Olanzapine And Risperidone Disrupt Conditioned Avoidance Responding In Phencyclidine-Pretreated Or Amphetamine-Pretreated Rats By Selectively Weakening Motivational Salience Of Conditioned Stimulus, Ming Li, Wei He, Alexa Mead
Olanzapine And Risperidone Disrupt Conditioned Avoidance Responding In Phencyclidine-Pretreated Or Amphetamine-Pretreated Rats By Selectively Weakening Motivational Salience Of Conditioned Stimulus, Ming Li, Wei He, Alexa Mead
Ming Li
The rat conditioned avoidance response model is a well-established preclinical behavioral model predictive of antipsychotic efficacy. All clinically approved antipsychotic drugs disrupt conditioned avoidance responding – a feature that distinguishes them from other psychotherapeutics. We previously showed that the typical antipsychotic drug haloperidol disrupts avoidance responding by progressively attenuating the motivational salience of the conditioned stimulus (CS) in normal rats. In this study, using two pharmacological rat models of schizophrenia [e.g. phencyclidine (PCP) or amphetamine sensitization], we examined whether atypicals such as olanzapine or risperidone disrupt avoidance responding through the same behavioral mechanism. Rats were first pretreated with PCP, amphetamine, …
The Traumatic Stress Response In Child Maltreatment And Resultant Neuropsychological Effects, Kathryn R. Wilson, David J. Hansen, Ming Li
The Traumatic Stress Response In Child Maltreatment And Resultant Neuropsychological Effects, Kathryn R. Wilson, David J. Hansen, Ming Li
Ming Li
Child maltreatment is a pervasive problem in our society that has long-term detrimental consequences to the development of the affected child such as future brain growth and functioning. In this paper, we surveyed empirical evidence on the neuropsychological effects of child maltreatment, with a special emphasis on emotional, behavioral, and cognitive process–response difficulties experienced by maltreated children. The alteration of the biochemical stress response system in the brain that changes an individual’s ability to respond efficiently and efficaciously to future stressors is conceptualized as the traumatic stress response. Vulnerable brain regions include the hypothalamic–pituitary–adrenal axis, the amygdala, the hippocampus, and …
C-Fos Identification Of Neuroanatomical Sites Associated With Haloperidol And Clozapine Disruption Of Maternal Behavior In The Rat, Changjiu Zhao, Ming Li
C-Fos Identification Of Neuroanatomical Sites Associated With Haloperidol And Clozapine Disruption Of Maternal Behavior In The Rat, Changjiu Zhao, Ming Li
Ming Li
Rat maternal behavior is a complex social behavior. Most antipsychotic drugs disrupt active maternal responses (e.g., pup retrieval, pup licking and nest building). Our previous work shows that typical antipsychotic haloperidol disrupts maternal behavior by blocking dopamine D2 receptors, whereas atypical clozapine works by blocking 5-HT2A/2C receptors. The present study used c-Fos immunohistochemistry technique, together with pharmacological tools and behavioral observations, and delineated the neuroanatomical bases of the disruptive effects of haloperidol and clozapine. Postpartum female rats were treated with haloperidol (0.2 mg/kg sc) or clozapine (10.0 mg/kg sc), with or without pretreatment of quinpirole (a selective dopamine D2/D3 agonist, …
Individual Differences In Responses To Nicotine: Tracking Changes From Adolescence To Adulthood, Ming Li, Alexa Mead, Rick A. Bevins
Individual Differences In Responses To Nicotine: Tracking Changes From Adolescence To Adulthood, Ming Li, Alexa Mead, Rick A. Bevins
Ming Li
Aim: The present study determined the extent to which individual differences in responses to the psychostimulating effect of nicotine during adolescence predict similar individual differences during adulthood in rats. We also examined the possible long-term effects of adolescent nicotine exposure on adult prepulse inhibition (PPI) of the acoustic startle response, a measure of sensorimotor gating ability. Methods: During the adolescent phase, rats were administered saline, 0.10, 0.40, or 0.60 mg/kg nicotine via subcutaneous injections for 8 days, and motor activity was measured daily. During the adult phase, these rats were treated with the same nicotine dose as in adolescence for …
Avoidance-Suppressing Effect Of Antipsychotic Drugs Is Progressively Potentiated After Repeated Administration: An Interoceptive Drug State Mechanism, Alexa Lucille Mead, Ming Li
Avoidance-Suppressing Effect Of Antipsychotic Drugs Is Progressively Potentiated After Repeated Administration: An Interoceptive Drug State Mechanism, Alexa Lucille Mead, Ming Li
Ming Li
Antipsychotic drugs selectively suppress conditioned avoidance response. Using a two-way active avoidance response paradigm, we examined the role of drug-induced interoceptive state in the mediation of avoidance-suppressive effect. In Experiment 1, we found that rats intermittently treated with olanzapine (OLZ) (1.0 mg/kg, s.c.) or haloperidol (0.03 mg/kg, s.c.) on the 1st day of a 3-day cycle for seven cycles exhibited a progressive across-session decline in avoidance responding, despite the fact that they exhibited a comparable high level of avoidance responding on the 3rd day of each cycle during the drug-free retraining session. In Experiments 2 and 3, rats that were …
Clozapine And Olanzapine Exhibit An Intrinsic Anxiolytic Property In Two Conditioned Fear Paradigms: Contrast With Haloperidol And Chlordiazepoxide, Alexa Mead, Ming Li, Shitij Kapur
Clozapine And Olanzapine Exhibit An Intrinsic Anxiolytic Property In Two Conditioned Fear Paradigms: Contrast With Haloperidol And Chlordiazepoxide, Alexa Mead, Ming Li, Shitij Kapur
Ming Li
Psychotic fear and anxiety disturbances are seen at a relatively high frequency in patients with schizophrenia. Atypical anti-psychotics are believed to show superior efficacy in reducing these symptoms. However, clinical and preclinical evidence regarding their anxiolytic efficacy has been mixed. In this study, we evaluated the possible anxiolytic property of two atypicals, clozapine and olanzapine, and compared them with typical haloperidol and chlordiazepoxide (a prototype of sedative-anxiolytic drug) in two preclinical models of fear. In Experiment 1, we used a fear-induced passive avoidance and conditioned place aversion paradigm and examined the effects of clozapine (20 mg/kg, sc), haloperidol (0.05 mg/kg, …
Amphetamine Selectively Enhances Avoidance Responding To A Less Salient Stimulus In Rats, Ming Li, Wei He, Rebecca Munro
Amphetamine Selectively Enhances Avoidance Responding To A Less Salient Stimulus In Rats, Ming Li, Wei He, Rebecca Munro
Ming Li
This preclinical study examined the psychological processes affected by amphetamine that contribute to human psychosis. Using a novel avoidance conditioning paradigm involving two conditioned stimuli (CS) with varied salience, we found that acute amphetamine (1.5 mg/ kg, i.p.) selectively enhanced avoidance responding to a less salient stimulus, but not to a salient one. These findings suggest that elevated dopaminergic activity selectively enhances the attributions of motivational salience to a less salient stimulus, a process that may bear relevance to the development of human delusional thoughts.
The Receptor Mechanisms Underlying The Disruptive Effects Of Haloperidol And Clozapine On Rat Maternal Behavior: A Double Dissociation Between Dopamine D2 And 5-Ht2a/2c Receptors, Zhao Changjiu, Ming Li
The Receptor Mechanisms Underlying The Disruptive Effects Of Haloperidol And Clozapine On Rat Maternal Behavior: A Double Dissociation Between Dopamine D2 And 5-Ht2a/2c Receptors, Zhao Changjiu, Ming Li
Ming Li
Many antipsychotic drugs disrupt active components of maternal behavior such as pup approach, pup retrieval and nest building at clinically relevant doses in postpartum female rats. However, the neurochemical mechanisms underlying such a disruptive effect remain to be determined. This study examined the neurochemical mechanisms that mediate the disruptive effects of haloperidol (a typical antipsychotic) and clozapine (an atypical antipsychotic) on rat maternal behavior. Postpartum rats were administered with haloperidol (0.2 mg/kg, sc) or clozapine (10.0 mg/kg, sc) together with either vehicle (saline or water), quinpirole (a selective dopamine D2/D3 agonist, 0.5 or 1.0 mg/kg, sc), or 2,5-dimethoxy-4-iodo-amphetamine (DOI, a …
Clozapine, But Not Olanzapine, Disrupts Conditioned Avoidance Response In Rats By Antagonizing 5-Ht2a/2c Receptors, Ming Li, Tao Sun, Alexa Mead
Clozapine, But Not Olanzapine, Disrupts Conditioned Avoidance Response In Rats By Antagonizing 5-Ht2a/2c Receptors, Ming Li, Tao Sun, Alexa Mead
Ming Li
The present study was designed to assess the role of 5-HT2A/2C receptors in the acute and repeated effect of clozapine and olanzapine in a rat conditioned avoidance response model, a validated model of antipsychotic activity. Male Sprague–Dawley rats that were previously treated with either phencyclidine (0.5–2.0 mg/kg, sc), amphetamine (1.25–5.0 mg/kg, sc), or saline and tested in a prepulse inhibition of acoustic startle study were used. They were first trained to acquire avoidance response to a white noise (CS1) and a pure tone (CS2) that differed in their ability to predict the occurrence of footshock. Those who acquired avoidance response …
An Investigation Of The Behavioral Mechanisms Of Antipsychotic Action Using A Drug-Drug Conditioning Paradigm, Ming Li, Wei He, Alexa Mead
An Investigation Of The Behavioral Mechanisms Of Antipsychotic Action Using A Drug-Drug Conditioning Paradigm, Ming Li, Wei He, Alexa Mead
Ming Li
Antipsychotic drugs at noncataleptic doses selectively suppress conditioned avoidance response in rats. In our previous study, we had used a two-way active avoidance response paradigm to show that the antipsychotic-induced interoceptive state is one of the mechanisms underlying the avoidance-disruptive effect of antipsychotics. In this study, we sought to further examine this mechanism using a novel drug-drug conditioning procedure. We made use of the fact that both the typical neuroleptic haloperidol and the atypical neuroleptic olanzapine disrupt conditioned avoidance responding, whereas chlordiazepoxide (an anxiolytic) does not. We reasoned that if the antipsychotic interoceptive state is important in causing a disruption …
Sedation And Disruption Of Maternal Motivation Underlie The Disruptive Effects Of Antipsychotic Treatment On Rat Maternal Behavior, Changjiu Zhao, Ming Li
Sedation And Disruption Of Maternal Motivation Underlie The Disruptive Effects Of Antipsychotic Treatment On Rat Maternal Behavior, Changjiu Zhao, Ming Li
Ming Li
The behavioral mechanisms underlying antipsychotic-induced maternal behavior deficits were examined in the present study. Different groups of postpartum rats were treated with haloperidol (0.1 mg/kg), clozapine (10.0 mg/kg), chlordiazepoxide (5.0 mg/kg, an anxiolytic) or vehicle (0.9% saline) on Days 4 and 6 postpartum and their maternal behaviors were tested under either pup-separation (e.g. pups were removed from their mothers for 4 h before testing) or no-pup-separation condition. Maternal behavior and drug-induced sedation were further tested for 3 days from Day 8 to 12 postpartum. Results show that pup-separation, which putatively increases maternal motivation, did significantly shorten clozapine-elongated pup approach latency, …
Repeated Antipsychotic Treatment Progressively Potentiates Inhibition On Phencyclidine-Induced Hyperlocomotion, But Attenuates Inhibition On Amphetamine-Induced Hyperlocomotion: Relevance To Animal Models Of Antipsychotic Drugs, Tao Sun, Gang Hu, Ming Li
Repeated Antipsychotic Treatment Progressively Potentiates Inhibition On Phencyclidine-Induced Hyperlocomotion, But Attenuates Inhibition On Amphetamine-Induced Hyperlocomotion: Relevance To Animal Models Of Antipsychotic Drugs, Tao Sun, Gang Hu, Ming Li
Ming Li
Clinical obervations indicate that antipsychotic action starts early and increases in magnitude with repeated treatment. Animal models that faithfully capture this time course of action are few. Inhibition of hyperlocomotion induced by amphetamine or phencyclidine has been widely used as a screening tool for the antipsychotic activity of a drug. We thus investigated whether repeated antipsychotic treatment could produce an early-onset and progressively increased antagonistic effect on amphetamine or phencyclidine-induced hyperlocomotion as a way of assessing the validity of such models in capturing time course of antipsychotic action. One each of the five consecutive test days, different groups of rats …
Methamphetamine-Associated Psychosis, Kathleen M. Grant, Tricia D. Le Van, Sandra M. Wells, Ming Li, Scott F. Stoltenberg, Howard E. Gendelman, Gustavo Carlo, Rick A. Bevins
Methamphetamine-Associated Psychosis, Kathleen M. Grant, Tricia D. Le Van, Sandra M. Wells, Ming Li, Scott F. Stoltenberg, Howard E. Gendelman, Gustavo Carlo, Rick A. Bevins
Ming Li
Methamphetamine (METH) is a frequent drug of abuse in U.S. populations and commonly associated with psychosis. This may be a factor in frequent criminal justice referrals and lengthy treatment required by METH users. Persecutory delusions and auditory hallucinations are the most consistent symptoms of METH-associated psychosis (MAP). MAP has largely been studied in Asian populations and risk factors have varied across studies. Duration, frequency and amount of use as well as sexual abuse, family history, other substance use, and co-occurring personality and mood disorders are risk factors for MAP. MAP may be unique with its long duration of psychosis and …
Anxiolytic-Like Property Of Risperidone And Olanzapine As Examined In Multiple Measures Of Fear In Rats, Tao Sun, Wei He, Gang Hu, Ming Li
Anxiolytic-Like Property Of Risperidone And Olanzapine As Examined In Multiple Measures Of Fear In Rats, Tao Sun, Wei He, Gang Hu, Ming Li
Ming Li
Atypical antipsychotics are also used in the treatment of anxiety-related disorders. Clinical and preclinical evidence regarding their intrinsic anxiolytic efficacy has been mixed. In this study, we examined the potential anxiolytic-like effects of risperidone and olanzapine, and compared them with haloperidol, chlordiazepoxide (a prototype of sedative–anxiolytic drug) or citalopram (a selective serotonin reuptake inhibitor). We used a composite of two-way avoidance conditioning and acoustic startle reflex model and examined the effects of drug treatments during the acquisition phase (Experiment 1) or extinction phase (Experiments 2 and 3) on multiple measures of conditioned and unconditioned fear/anxiety-like responses. In Experiment 4, we …