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Full-Text Articles in Medicine and Health Sciences

Stereological Assessment Of The Thalamus In A Rat Model Of Periventricular Nodular Heterotopia, Jason Lennox Apr 2012

Stereological Assessment Of The Thalamus In A Rat Model Of Periventricular Nodular Heterotopia, Jason Lennox

Honors Projects

Malformations of neocortical development such as microgyria (MG) and periventricular nodular heterotopia (PNH) have been observed in the brains of language learning impaired (LLI) humans. Rats with MG have shown rapid auditory processing (RAP) deficits similar to acoustic deficits observed in some human LLI populations. Threlkeld et al., (2009) previously reported RAP and other learning impairments in rats with PNH resulting from disruption to embryonic neuronal cell division by way of Methylazoxymethanol (MAM) treatment on embryonic day 15 (E15). The thalamus and its subnuclei may be vulnerable to neurodevelopmental disruptions. Studies of MG rats have shown changes in cell size …


Relationship Between Hair Cortisol And Perceived Chronic Stress In A Diverse Sample, Kymberlee O'Brien, E. Z. Tronick, C. L. Moore Jan 2012

Relationship Between Hair Cortisol And Perceived Chronic Stress In A Diverse Sample, Kymberlee O'Brien, E. Z. Tronick, C. L. Moore

Faculty Publications

Hair cortisol (CORT) is a biomarker of chronic stress via long-termalterations in hypothalamus–pituitary–adrenal axis activity. Relationships to perceived stressmeasures, however, have rarely been specifically investigated. A diverse sample of 135 adults participated in a study assessing relationships between chronic stress indicator CORT to perceived stress and health indicators. CORT was not correlated to single perceived domain indices but with a global stress composite. Differences in objective and subjective measures were found for sociodemographics: racial/ethnic identity, sex and socioeconomic status (SES). Race by SES interactions predicted both CORT and perceived stress, but produced a complex and partially unanticipated pattern of results. …


Relational Psychophysiology And Mutual Regulation During Dyadic Therapeutic And Development Relating, Kymberlee O'Brien Jan 2012

Relational Psychophysiology And Mutual Regulation During Dyadic Therapeutic And Development Relating, Kymberlee O'Brien

Faculty Publications

Human experiences of empathy and presence are quintessential in therapeutic as well as intimate relationships. The work on relational psychophysiology has informed psychotherapeutic research by illustrating how early life physiological concordance between mother and infant are critical in mutual dyadic regulation. These processes cross several developmental domains, including biological, affective, social, and self-identity. By examining physiological concordance, this research has propelled our understanding of mutual regulation into the more expansive understanding of dyadically expanded states of consciousness. The core of the therapeutic relationship inherently engenders expanded opportunities and reorganization of the client, as well as the therapist. By incorporating the …


Healthy, Wealthy, Wise? Psychosocial Factors Influencing The Socioeconomic Status-Health Gradient, Kymberlee O'Brien Jan 2012

Healthy, Wealthy, Wise? Psychosocial Factors Influencing The Socioeconomic Status-Health Gradient, Kymberlee O'Brien

Faculty Publications

The present research investigated psychosocial factors: control beliefs; social relations moderating the SES–health gradient. Participants included 3775 respondents from a national probability sample, Midlife in United States (t1: Age, M = 46.40, SD = 13.00, t2: Age, M = 55.47, SD = 12.43), who provided reports on control beliefs, social relations, and health at two assessment occasions (1994/1995 and 2002/2003). Hierarchical regression demonstrated that control beliefs, social support, and strain uniquely moderated relationships between SES and longitudinal health. The present study highlights the importance of psychosocial factors as protective mechanisms of socioeconomic disadvantages and associated long-term deleterious health outcomes.