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Full-Text Articles in Medicine and Health Sciences
Multiple “Hits” During Postnatal And Early Adulthood Periods Disrupt The Normal Development Of Sensorimotor Gating Ability In Rats, Jing Chen, Zucheng Wang, Ming Li
Multiple “Hits” During Postnatal And Early Adulthood Periods Disrupt The Normal Development Of Sensorimotor Gating Ability In Rats, Jing Chen, Zucheng Wang, Ming Li
Department of Psychology: Faculty Publications
In the present study, we evaluated a multiple-hit animal model of schizophrenia in an attempt to capture the complex interactions among various adverse developmental factors in schizophrenia. Sprague–Dawley rats were assigned to receive either repeated daily 3-h maternal separation for eight days (first “hit”) on postnatal days (PND) 3 to 10, and/or avoidance conditioning for six days (second “hit”) on PND 49–56, and/or repeated phencyclidine treatment (third “hit”, 3.0 mg/kg, sc) immediately after each daily avoidance conditioning. Prepulse inhibition (PPI) of acoustic startle reflex was assessed at late adolescence (PND 41–43) and early adulthood (PND 62–63). The change in %PPI …