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Full-Text Articles in Medicine and Health Sciences
Serotonin Transporter And Gaba(A) Alpha 6 Receptor Variants Are Associated With Neuroticism, Srijan Sen, Sandra Villafuerte, Randolph Nesse, Scott F. Stoltenberg, Jeffrey Hopcian, Lillian Gleiberman, Alan Weder, Margit Burmeister
Serotonin Transporter And Gaba(A) Alpha 6 Receptor Variants Are Associated With Neuroticism, Srijan Sen, Sandra Villafuerte, Randolph Nesse, Scott F. Stoltenberg, Jeffrey Hopcian, Lillian Gleiberman, Alan Weder, Margit Burmeister
Scott F. Stoltenberg
Background: A tendency to experience negative affect, as measured by the neuroticism component of the Neuroticism, Extraversion, and Openness Personality Inventory (NEO-PI), is a trait marker for major depression. Epidemiologic studies indicate a strong genetic component, but to date few specific genetic variants have been definitively implicated. A serotonin transporter promoter polymorphism (5-HTTLPR) has been extensively studied in neuroticism and several psychiatric disorders, with inconclusive results. A GABA(A) receptor α6 subunit variant (Pro385Ser) has been associated with alcohol-related traits but has not been studied in neuroticism or depression. Methods: A total of 384 subjects who completed the NEO-PI were genotyped …
A Bdnf Coding Variant Is Associated With The Neo Personality Inventory Domain Neuroticism, A Risk Factor For Depression, Srijan Sen, Randolph M. Nesse, Scott F. Stoltenberg, Sheng Li, Lillian Gleiberman, Aravinda Chakravarti, Alan B. Weber, Margit Burmeister
A Bdnf Coding Variant Is Associated With The Neo Personality Inventory Domain Neuroticism, A Risk Factor For Depression, Srijan Sen, Randolph M. Nesse, Scott F. Stoltenberg, Sheng Li, Lillian Gleiberman, Aravinda Chakravarti, Alan B. Weber, Margit Burmeister
Scott F. Stoltenberg
Genetic factors influence vulnerability to depression (Sullivan et al, 2000), but no specific genes have been definitively implicated. One promising approach is to determine whether variations in specific (candidate) genes are associated not with disease per se, but with traits, such as personality factors, that are themselves associated with risk for the disorder (Lander and Schork, 1994; Stoltenberg and Burmeister, 2000). Often such traits have a higher heritability than the disease status (Almasy and Blangero, 2001). Neuroticism, as measured by the NEO personality inventory (NEO-PI) (Costa and McCrae, 1997), a psychometrically sound and widely used instrument, is one such trait. …