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Epistasis Among Presynaptic Serotonergic System Components, Scott Stoltenberg
Epistasis Among Presynaptic Serotonergic System Components, Scott Stoltenberg
Scott F. Stoltenberg
Epistatic interactions among regulatory components of the serotonin (5-HT) neurotransmitter system may be an important aspect of 5-HT function. Because 5-HT dysregulation is associated with several common psychiatric disorders, the potential for epistasis among genetic variants in the 5-HT transporter (SERT), 5-HT1B terminal autoreceptor and the 5- HT1A somatodendritic autoreceptor should be examined. In this study, output from a dynamic minimal model of 5-HT function was compared to empirical results in the literature. Parameters representing extracellular 5-HT clearance rates (SERT), 5-HT release levels (5-HT1B) and inhibitory thresholds (the amount of extracellular 5-HT above which cell firing is inhibited, an indication …