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Full-Text Articles in Medicine and Health Sciences
Concussion-Related Symptomatology And Outcomes In Individuals With Mental Health Conditions: Symptom Number And Severity, Balance Performance, And Time Course To Discharge, Kathryn J. Schulze
Concussion-Related Symptomatology And Outcomes In Individuals With Mental Health Conditions: Symptom Number And Severity, Balance Performance, And Time Course To Discharge, Kathryn J. Schulze
Electronic Thesis and Dissertation Repository
Symptomatology can overlap between concussions and common mental health conditions (MHCs) – such as anxiety, depression, and attention-deficit/hyperactivity disorder. Research determined that there can be an onset of new or worsening symptoms related to pre-existing MHCs in individuals post-concussion. Pre-existing MHCs may affect concussion outcomes. Therefore, the relationship between pre-existing MHCs and concussions was further examined. Study One examined the difference in symptom severity and number of symptoms reported at the initial clinical assessment for concussion for individuals with and without a pre-existing MHC. A chart review determined that individuals with anxiety or multiple MHCs had significantly more concussion symptoms …
Oxytocin’S Effects On Sickness Behaviours, Anxiety Responses, And Immune Function In Adult Male Mice, Julie Deleemans
Oxytocin’S Effects On Sickness Behaviours, Anxiety Responses, And Immune Function In Adult Male Mice, Julie Deleemans
Electronic Thesis and Dissertation Repository
The nonapeptide, oxytocin (OT), is implicated in a range of behavioural and physiological functions. However, OT's role in sickness behaviours remains unclear. This thesis examined effects of the OT agonist, carbetocin (CBT), and OT antagonist, L-368,899, on anxiety and locomotor sickness-related behaviours and pro-inflammatory cytokines, TNF-a and IL-6, in adult male CD-1 mice. Animals received 2 intraperitoneal treatment injections. The first treatment was carbetocin, L-368,899, or saline, while the second was lipopolysaccharide (LPS) or saline. Behaviours were evaluated via the light-dark test, and cytokines via immunoassay. OT antagonist treatment attenuated LPS induced perturbations in locomotor and anxiety-like behaviour, but …
The Effects Of Pre- And Postnatal Administration Of Propionic Acid And Lipopolysaccharide On The Behaviour Of Adolescent Male And Female Rats, Kelly A. Foley
The Effects Of Pre- And Postnatal Administration Of Propionic Acid And Lipopolysaccharide On The Behaviour Of Adolescent Male And Female Rats, Kelly A. Foley
Electronic Thesis and Dissertation Repository
The gut microbiome plays an important role in immune functioning and neurodevelopment. Altered microbiome composition, leading to short chain fatty acid, and/or immune system dysfunction has been observed in children with autism spectrum disorders (ASD). This thesis describes the developmental influence of prenatal exposure to propionic acid (PPA), a metabolic fermentation product of enteric bacteria, or prenatal exposure to lipopolysaccharide (LPS), a bacterial mimetic and product of enteric bacteria, on a range of behaviours in male and female neonatal, adolescent and adult rats. Study one evaluated the effects of prenatal PPA and LPS, and postnatal PPA, on developmental milestones in …