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Full-Text Articles in Medicine and Health Sciences
Multiple “Hits” During Postnatal And Early Adulthood Periods Disrupt The Normal Development Of Sensorimotor Gating Ability In Rats, Jing Chen, Zucheng Wang, Ming Li
Multiple “Hits” During Postnatal And Early Adulthood Periods Disrupt The Normal Development Of Sensorimotor Gating Ability In Rats, Jing Chen, Zucheng Wang, Ming Li
Department of Psychology: Faculty Publications
In the present study, we evaluated a multiple-hit animal model of schizophrenia in an attempt to capture the complex interactions among various adverse developmental factors in schizophrenia. Sprague–Dawley rats were assigned to receive either repeated daily 3-h maternal separation for eight days (first “hit”) on postnatal days (PND) 3 to 10, and/or avoidance conditioning for six days (second “hit”) on PND 49–56, and/or repeated phencyclidine treatment (third “hit”, 3.0 mg/kg, sc) immediately after each daily avoidance conditioning. Prepulse inhibition (PPI) of acoustic startle reflex was assessed at late adolescence (PND 41–43) and early adulthood (PND 62–63). The change in %PPI …
Anger, Child Behavior, And Family Distress: Further Evaluation Of The Parental Anger Inventory, Georganna Sedlar, David J. Hansen
Anger, Child Behavior, And Family Distress: Further Evaluation Of The Parental Anger Inventory, Georganna Sedlar, David J. Hansen
Department of Psychology: Faculty Publications
Presumably, anger is a common experience of parenting. Although practitioners and researchers recognize the role of anger in various parenting situations, objective and standardized measures of parental anger have been notably lacking in the field. This study examined the Parental Anger Inventory (PAI), a measure developed specifically to assess parental anger in response to child misbehavior. A diverse sample of 98 parents participated in the study, including (a) physically abusive or neglectful parents, or both, n = 44; (b) nonmaltreating clinic parents seeking assistance for child behavior problems, n = 24; and (c) nonmaltreating, non–help-seeking community parents, n = 30. …
Individual Differences In Rat Locomotor Activity Are Diminished By Nicotine Through Stimulation Of Central Nicotinic Acetylcholine Receptors, Rick A. Bevins, Joyce Besheer
Individual Differences In Rat Locomotor Activity Are Diminished By Nicotine Through Stimulation Of Central Nicotinic Acetylcholine Receptors, Rick A. Bevins, Joyce Besheer
Department of Psychology: Faculty Publications
An increasing body of research has focused on isolating factors that predict or alter individual differences in the behavioral and neural processes mediating the effects of abused drugs. Within this framework, the current report assessed individual differences and the locomotor effect of nicotine. Rats were screened for activity induced by a novel environment. Rats, which were more active to initial environment exposure, remained more active even after seven additional 30-min exposures to the same environment. Treatment with nicotine-di-D tartrate (1 mg/kg, sc) disrupted this effect. This nicotine disruption of individual differences occurred whether nicotine suppressed locomotor activity (initial administration) or …