Medicine and Health Sciences Commons^™

Role Of Naltrexone In Improving Compulsive Drinking In Psychogenic Polydipsia, Sukaina Rizvi, Jeffery Gold, Ali M. Khan

School of Medicine Publications and Presentations

Psychogenic polydipsia or self-induced water intoxication is a potentially lethal condition seen in many chronic psychiatric patients. This is a literature review based on therapeutic significance of Naltrexone in improving compulsive water drinking behavior in chronic psychiatrically ill patients with psychogenic polydipsia. Naltrexone is an opioid antagonist approved by FDA for alcohol dependence. Extensive literature search provides a line of evidence that suggests correlation of opioid receptor with compulsive water ingestion in animals. However, there is limited data regarding clinical utility of naltrexone in improving psychogenic polydipsia in human species. This review highlights the necessity for further research and trials …

The Effectiveness Of Selective Serotonin Reuptake Inhibitors For Treatment Of Obsessive-Compulsive Disorder In Adolescents And Children: A Systematic Review And Meta-Analysis, Vijaya P. Kotapati, Ali M. Khan, Sara Dar, Gulshan Begum, Ramya Bachu, Mahwish Adnan, Aarij Zubair, Rizwan A. Ahmed

School of Medicine Publications and Presentations

Background: Obsessive-compulsive disorder (OCD) is a common behavioral disorder among adolescents and children. The selective serotonin reuptake inhibitors (SSRIs) are the first pharmacological choice for this condition due to mild adverse effect profile.

Objective: This systematic review was performed to evaluate the efficacy of SSRI for OCD in adolescents and children.

Methods: Search terms were entered into PubMed, PsycINFO, Scopus, CINAHL, and Google Scholar. The included studies were randomized, placebo-controlled trials of SSRIs conducted in populations of children and adolescents younger than 18 years. Change from baseline Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS), end-treatment CY-BOCS with respective SD, and response and …

Use Of Transcranial Magnetic Stimulation For Depression, Sukaina Rizvi, Ali M. Khan

School of Medicine Publications and Presentations

Transcranial magnetic stimulation (TMS), a research tool with various effects on brain cells, can depolarize cerebral neurons noninvasively. This method offers temporal and spatial resolution and can be combined with other neurocognitive and neuro-experimental techniques. Prefrontal TMS therapy repeated daily for four to six weeks is a neuromodulation technique approved by the US Food and Drug Administration for the treatment of major depressive disorder (MDD) in patients resistant to medications. This technique utilizes electromagnetic induction to excite neuronal cells. Several recent studies have enhanced our understanding of this novel treatment intervention. This report reviews recent studies on the mechanism of …

Use Of Gabapentin In The Treatment Of Substance Use And Psychiatric Disorders: A Systematic Review, Saeed Ahmed, Ramya Bachu, Vijaya P. Kotapati, Mahwish Adnan, Rizwan A. Ahmed, Umer Farooq, Hina Saeed, Ali M. Khan, Aarij Zubair, Iqra Qamar, Gulshan Begum

School of Medicine Publications and Presentations

Objective: Gabapentin (GBP) is an anticonvulsant medication that is also used to treat restless legs syndrome (RLS) and posttherapeutic neuralgia. GBP is commonly prescribed off-label for psychiatric disorders despite the lack of strong evidence. However, there is growing evidence that GBP may be effective and clinically beneficial in both psychiatric disorders and substance use disorders. This review aimed to perform a systematic analysis of peer-reviewed published literature on the efficacy of GBP in the treatment of psychiatric disorders and substance use disorders.

Methods: This review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. …