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Adenosine; acetylcholine; classical conditioning; discriminative stimulus; dopamine; drug discrimination; modulator; negative feature; occasion setter; reward learning
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The Interoceptive Pavlovian Stimulus Effects Of Caffeine, Jennifer Murray, Chia Li, Matthew I. Palmatier, Rick A. Bevins
The Interoceptive Pavlovian Stimulus Effects Of Caffeine, Jennifer Murray, Chia Li, Matthew I. Palmatier, Rick A. Bevins
Rick A. Bevins
The present research sought to test whether caffeine functioned as a Pavlovian cue in two ways—as a positive drug feature or as a conditional stimulus (CS). As a positive feature (Experiment 1), brief light presentations were followed by sucrose only on sessions in which caffeine (10 mg/kg) was administered. On intermixed saline sessions, light presentations were not followed by sucrose. The light came to control robust goal-tracking (i.e., conditioned responding) only in caffeine sessions. Thus, caffeine disambiguates when the light was paired with sucrose. Decreasing the dose of caffeine decreased the conditioned responding evoked by the light (ED50=4.16 mg/kg). Neither …