Medicine and Health Sciences Commons^™

Sex Differences In Cognitive Flexibility Are Driven By The Estrous Cycle And Stress-Dependent, Andrew T. Gargiulo, Jiayin Hu, Isabella C. Ravaglia, Annie Hawks, Xinyue Li, Katherine Sweasy, Laura A. Grafe

Psychology Faculty Research and Scholarship

Stress is associated with psychiatric disorders such as post-traumatic stress disorder, major depressive disorder, anxiety disorders, and panic disorders. Women are more likely to be diagnosed with these stress-related psychiatric disorders than men. A key phenotype in stress-related psychiatric disorders is impairment in cognitive flexibility, which is the ability to develop new strategies to respond to different patterns in the environment. Because gonadal hormones can contribute to sex differences in response to stress, it is important to consider where females are in their cycle when exposed to stress and cognitive flexibility testing. Moreover, identifying neural correlates involved in cognitive flexibility …

Sex Differences In Stress-Induced Sleep Deficits, Andrew T. Gargiulo, Varuna Jasodanand, Sandra Luz, Lauren O'Mara, Leszek Kubin, Richard J. Ross, Seema Bhatnagar, Laura A. Grafe

Psychology Faculty Research and Scholarship

Sleep disruptions are hallmarks in the pathophysiology of several stress-related disorders, including Major Depressive Disorder (MDD) and Post-Traumatic Stress Disorder (PTSD), both known to disproportionately affect female populations. Although previous studies have attempted to investigate disordered sleep in women, few studies have explored and compared how repeated stress affects sleep in both sexes in either human or animal models. We have previously shown that male rats exhibit behavioral and neuroendocrine habituation to 5 days of repeated restraint, whereas females do not; additional days of stress exposure are required to observe habituation in females. This study examined sex differences in sleep …

Stress, Coping, Resilience, And Sleep During The Covid-19 Pandemic: A Representative Survey Study Of Us Adults, Andrew T. Gargiulo, Laurel M. Peterson, Laura A. Grafe

Psychology Faculty Research and Scholarship

Introduction: The COVID-19 pandemic is a global health emergency resulting in widespread death and substantial disruption to daily life. Previous research has shown that novel disease outbreaks are associated with high stress levels and sleep impairments that lead to neuropsychiatric consequences. Therefore, it is vital to study both stress and protective factors such as coping and resilience that may hinder or help sleep quality during the COVID-19 pandemic. Further, as gender disparities exist in sleep quality, it is important to understand the relationship between pandemic-related stress, coping strategies, resilience, and sleep in bothgenders during the COVID-19 pandemic.

Methods: Our study …